Neonatal Cholestasis

If Kasai Fails?
+/- support for revision of Kasai procedure if fails
Despite clinical improvement after a Kasai, 70-80% pts will
eventually require liver transplantation
Indications for Liver Transplant:
operation not successful in restoring bile flow initially
(~20%)
late referrals (generally >120 days)
develop end-stage liver dz despite bile drainage (ie
portal htn, recurrent cholangitis, ascites, growth failure)
Liver Transplant results:
one-yr survival rates >90% b/c reduced size allografts
and living-related donors