Neonatal Cholestasis
Neonatal Cholestasis
Neonatal Cholestasis
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Differential Diagnosis:<br />
Hepatocellular <strong>Cholestasis</strong><br />
Idiopathic neonatal hepatitis<br />
Diagnosis based on liver biopsy findings: “giant cell hepatitis”<br />
Was thought to account for ~40% of neonatal cholestasis<br />
(with new diagnostic techniques, % is probably ~10-20%)<br />
60-70% resolve without sequelae<br />
Infectious<br />
Viral: TORCH, CMV, HIV, viral hepatitis<br />
Bacterial: sepsis, syphilis, UTI<br />
Genetic/metabolic<br />
Alpha-1-antitrysin deficiency, galactosemia, tyrosinemia,<br />
hypothyroid, PFIC, CF<br />
Toxic/secondary causes<br />
TPN associated cholestasis
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