Glossary of HIV/AIDS-Related Terms - AIDSinfo - National Institutes ...

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Clinical Alert
An early notice of urgent findings from federally funded clinical trials.
Clinical alerts are disseminated in a variety of ways, including online, to
advise health care professionals and others of research findings that
could affect patient care.
SEE RELATED TERM(S): Clinical Trial
Clinical Endpoint
ALSO KNOWN AS: Endpoint, Outcome Measure
In a clinical trial, an outcome or event used to objectively measure the
effect of a drug or other intervention being studied. Common
endpoints include severe toxicity, disease progression, and death.
SEE RELATED TERM(S): Clinical Trial, Surrogate Endpoint
Clinical Failure
A type of HIV treatment failure. The occurrence or recurrence of an
HIV-related complication, usually an AIDS-defining condition, after 3
months of antiretroviral therapy (ART) is considered clinical failure.
SEE RELATED TERM(S): AIDS-Defining Condition, Antiretroviral Therapy, Treatment Failure
Clinical Latency
ALSO KNOWN AS: Asymptomatic HIV Infection
Clinical Progression
Advance of disease that can be measured by observable and diagnosable
signs or symptoms. For example, HIV progression can be measured by
change in CD4 count.
SEE RELATED TERM(S): CD4 Count, HIV Progression
Clinical Trial
A research study that determines whether a new drug (or other
intervention) is both safe and effective for humans. There are two main
types of clinical trials: interventional trials and observational trials.
SEE RELATED TERM(S): Interventional Trial, Observational Trial, Phase I Trial, Phase II
Trial, Phase III Trial, Phase IV Trial
26 HIV/AIDS Glossary