Glossary of HIV/AIDS-Related Terms - AIDSinfo - National Institutes ...

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Drug Interaction
A change in a drug’s effect on the body when taken with certain other
drugs, supplements, or food, or when taken together with certain
medical conditions. A drug interaction may cause the drug to be less
effective, cause adverse effects, or increase the action of the drug.
Potential drug interactions are considered when selecting antiretroviral
(ARV) drugs to include in an HIV treatment regimen.
SEE RELATED TERM(S): Drug-Drug Interaction, Drug-Food Interaction
Drug Opposition
ALSO KNOWN AS: Drug Antagonism
Drug Reaction with Eosinophilia and Systemic Symptoms
ALSO KNOWN AS: Hypersensitivity Syndrome
Drug Resistance
ALSO KNOWN AS: Resistance
When a bacteria, virus, or other microorganism mutates (changes form)
and becomes insensitive to (resistant to) a drug that was previously
effective. Drug resistance can be a cause of HIV treatment failure.
SEE RELATED TERM(S): Acquired Resistance, Drug-Susceptible, Transmitted Resistance,
Treatment Failure
Drug Synergism
ALSO KNOWN AS: Synergism, Synergy
An interaction between two or more drugs that causes the total effect
of the drugs to be greater than the sum of the individual effects of
each drug. A synergistic effect can be beneficial or harmful.
SEE RELATED TERM(S): Drug Antagonism
Drug Toxicity
ALSO KNOWN AS: Toxicity
42 HIV/AIDS Glossary