LMB Cambridge - Helsinki Institute of Physics

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Micro-diffraction from Xylanase II Data collected on MarCCD165 Pixel size ~79 µm square Spot size limited by detector resolution and not by beam or crystal 6/26/2008 LMB, Cambridge
Summary: X-ray Detectors Potential Advantages Direct detection in Silicon – better resolution as no light scattering, even better resolution with Medipix3 Fast readout – fast framing (few milliseconds) possible Excellent S/N – noiseless readout, high dynamic range Detector and electronics separate – choose detector material (Si, GaAs, CdTe, …) for optimum efficiency See also: PILATUS contribution to this conference Downside Large area detectors difficult and expensive to build Individual detectors, ~2 cm 2 , tiled to obtain larger areas but gaps in between chips/modules leads to some dead space Technology not yet mature (?) – problems of ‘yield’ 6/26/2008 LMB, Cambridge
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Impact of silicon pixel detectors o
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MRC Laboratory of Molecular Biology
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Acknowledgements LMB Cambridge •R
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Main scientific aims •Structural
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Schematic of Microscope LMB-Cambrid
Page 11 and 12: Electron Cryo-Microscopy •Image m
Page 13 and 14: Rotavirus Epidemiology Deaths due t
Page 15 and 16: Side Chains 3.8 Å X-ray crystallog
Page 17 and 18: Bacteriorhodopsin •Membrane prote
Page 19 and 20: BR Model 6/26/2008 LMB, Cambridge H
Page 21 and 22: Electron Tomography 1. View specime
Page 23 and 24: Investigation into Mitotic Proteins
Page 25 and 26: Recent structures obtained using Cr
Page 27 and 28: Hepatitis B Structure Cryo-EM X-ray
Page 29 and 30: High Resolution Imaging Detector Re
Page 31 and 32: 300 kV EM with detector installed 6
Page 33 and 34: Monte Carlo simulation of electron
Page 35 and 36: Single Electron Clusters; 240 incid
Page 37 and 38: DQE(0) and DQE(Nyquist) DQE 6/26/20
Page 39 and 40: Rotavirus with 1.6(left) and 160(ri
Page 41 and 42: TMV: Results of image alignment Neg
Page 43 and 44: MAPS CMOS Detector - charged partic
Page 45 and 46: Monte Carlo simulation of electron
Page 47 and 48: MI-3 Consortium Members Professor N
Page 49 and 50: ADC Response for Single Electrons a
Page 51 and 52: Radhard Technology 512 x 512, 25 µ
Page 53 and 54: Large Area Sensor : Specifications
Page 55 and 56: Large Area Sensor - Mounted Courtes
Page 57 and 58: Medipix3 Silicon sensor, 300 or 500
Page 59 and 60: 55μ 4 5 6 7 DIGITAL CIRCUITRY 4. C
Page 61: Microcrystallography - A new applic
Page 65: Acknowledgements LMB Cambridge •R
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LMB Cambridge - Helsinki Institute of Physics

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