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uPA • A protease • It degrades barriers that normally prevent spread of cancer and opens up a pathway by which cancer cells can travel around the body • Present at higher levels in most cancers
uPA in Breast Cancer • We showed that breast cancer patients with high levels of uPA in their tumor developed metastasis and died earlier that patients with low levels • We showed that uPA was a stronger predictor of metastasis and early death than any previously described factor
Page 1 and 2: Breast Cancer Metastasis: Biomarker
Page 3 and 4: Most Important Questions After a Di
Page 5 and 6: Node-Negative Breast Cancer: Treatm
Page 7 and 8: ADJUVANT CHEMOTHERAPY FOR BREAST CA
Page 9 and 10: QUESTION Should most node-negative
Page 11: Invasion & Metastasis Invasive Carc
Page 15 and 16: uPA as Prognostic Markers in Breast
Page 17 and 18: LOE for Grading Clinical utility of
Page 19 and 20: Participating laboratories (9 count
Page 21 and 22: STRATIFICATION RANDOMISATION Prospe
Page 23 and 24: uPA in Breast Cancer: Implication o
Page 25 and 26: uPA for Determining Prognosis in Br
Page 27: Acknowledgements • HRB • Irish

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