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Pooled Analysis: Summary • uPA was an independent prognostic factors • uPA ranked second to nodal status but stronger than size, grade, HR, age • uPA prognostic in N- and N+ patients • uPA prognostic in untreated N- patients Look et al. JNCI 2002;94:116
STRATIFICATION RANDOMISATION Prospective Randomized German Multicenter Therapy Trial in Node-negative Breast Cancer uPA and PAI-1 low Observation Node-negative Breast Cancer T > 1 cm and < 5 cm 10 LN analyzed pre- / postmenopausal uPA and / or PAI-1 high Adjuvant Chemo (6 x CMF) Observation
Page 1 and 2: Breast Cancer Metastasis: Biomarker
Page 3 and 4: Most Important Questions After a Di
Page 5 and 6: Node-Negative Breast Cancer: Treatm
Page 7 and 8: ADJUVANT CHEMOTHERAPY FOR BREAST CA
Page 9 and 10: QUESTION Should most node-negative
Page 11 and 12: Invasion & Metastasis Invasive Carc
Page 13 and 14: uPA in Breast Cancer • We showed
Page 15 and 16: uPA as Prognostic Markers in Breast
Page 17 and 18: LOE for Grading Clinical utility of
Page 19: Participating laboratories (9 count
Page 23 and 24: uPA in Breast Cancer: Implication o
Page 25 and 26: uPA for Determining Prognosis in Br
Page 27: Acknowledgements • HRB • Irish

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