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uPA in Breast Cancer • We showed that uPA predicted the formation of metastasis and early death in patients with lymph node-negative disease • We confirmed our findings in an independent population of patients
uPA as Prognostic Markers in Breast Cancer • Prognostic impact of both confirmed by > 20 independent groups • Prognostic value independent of traditional factors • Prognostic value stronger than HER2, EGFR, CB, CD, p53 • Prognostic in patients with both N+ and N- disease
Page 1 and 2: Breast Cancer Metastasis: Biomarker
Page 3 and 4: Most Important Questions After a Di
Page 5 and 6: Node-Negative Breast Cancer: Treatm
Page 7 and 8: ADJUVANT CHEMOTHERAPY FOR BREAST CA
Page 9 and 10: QUESTION Should most node-negative
Page 11 and 12: Invasion & Metastasis Invasive Carc
Page 13: uPA in Breast Cancer • We showed
Page 17 and 18: LOE for Grading Clinical utility of
Page 19 and 20: Participating laboratories (9 count
Page 21 and 22: STRATIFICATION RANDOMISATION Prospe
Page 23 and 24: uPA in Breast Cancer: Implication o
Page 25 and 26: uPA for Determining Prognosis in Br
Page 27: Acknowledgements • HRB • Irish

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