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Annual Report 2006 - Boehringer Ingelheim

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enzymes, such as the HCV serine protease and<br />

RNA polymerase. Such new mechanisms offer the<br />

potential for new therapies with improved safety<br />

and efficacy compared to current treatments of<br />

chronic hepatitis C.<br />

Our virology drug discovery group in Laval has<br />

developed compounds with an alternative mode<br />

of action for the treatment of HCV infection. In<br />

clinical trials in infected patient volunteers, we<br />

established the short-term-efficacy for a new anti-<br />

viral principle and have one other compound in<br />

clinical phase I.<br />

Our ongoing activities in HCV continue to exploit<br />

these antiviral targets together with other novel<br />

approaches and are complemented by partnering<br />

efforts. In <strong>2006</strong>, we initiated a collaboration with<br />

the Australian company Biota to jointly discover<br />

and develop Biota’s novel nucleoside analogues<br />

designed to treat HCV infections and other<br />

diseases.<br />

serving patients<br />

Prescription Medicines<br />

9

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