Scientific CV in PDF format - IMP

Curriculum vitae
Dr. Stefan Westermann
DR. STEFAN WESTERMANN
PROFESSIONAL ADDRESS
Research Institute of Molecular Pathology (IMP)
Dr.Bohr-Gasse 7
1030-Vienna
Austria
Phone +43 1 79730-3450
Email: westermann@imp.ac.at
www.imp.ac.at/research/stefan-westermann
PERSONAL DATA
Date of Birth October 7, 1971
Place of Birth Hamm, Germany
Nationality
German
Education
PhD: Biochemistry, University of Hannover, Germany, November 26, 2001
Diplom: Biochemistry (grade 1.0), University of Hannover, November 1997
Abitur: (grade 1.0) Freiherr vom Stein Gymnasium, Hamm, Germany, 1991
PROFESSIONAL EXPERIENCE
Research Institute of Molecular Pathology (IMP), Vienna, Austria
Group leader, October 2006 – present
Molecular Mechanisms of Kinetochore Function
University of California at Berkeley, USA, Laboratory of Dr. David Drubin and
Dr. Georjana Barnes, Department of Molecular and Cell Biology
Postdoctoral Fellow, August 2002- August 2006
Genetic and biochemical analysis of the Budding Yeast Kinetochore
Max-Planck Institute for Biophysical Chemistry, Goettingen, Germany,
Laboratory of Dr. Klaus Weber, Department of Biochemistry
PhD student November 1997 – July 2002
Purification and Characterization of Tubulin Polyglutamylase
Diploma student April 1997 - October 1997
HONORS AND AWARDS
PhD awarded summa cum laude 2001
Best Paper Award 2002 Journal of Cell Science
Postdoctoral Fellowship German Research Foundation (DFG) 2002
ERC starting investigator grant 2008
Young Member Austrian Academy of Science 2009
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Curriculum vitae
Dr. Stefan Westermann
FUNDING INFORMATION
External Grants
ERC Starting Investigator Grant “KinetoCore”- No. 203449
SFB F34-B03 “Chromosome Dynamics” by Austrian Science Fund FWF
PUBLICATIONS
Stefan Westermann and Alexander Schleiffer (2013). Family Matters: Structural and
Functional Conservation of Centromere-associated proteins from yeast to humans.
Trends in Cell Biology, epub 10.1016/j.tcb.2013.01.010
Francesca Malvezzi, Gabriele Litos, Alexander Schleiffer, Alexander Heuck, Tim
Clausen and Stefan Westermann (2013). A structural basis for kinetochore recruitment
of the Ndc80 complex via two distinct centromere receptors, EMBO J.,
doi:10.1038/emboj.2012.356
Fabienne Lampert, Christine Mieck, Gregory Alushin, Eva Nogales and Stefan
Westermann (2013). Molecular requirements for the formation of a kinetochoremicrotubule
interface by Dam1 and Ndc80 complexes, J.Cell Biology 200:21-30
Comment “In this issue: Kinetochore complexes need teamwork” J.Cell Biology 200
(1):p 2
Alexander Schleiffer, Michael Maier, Gabriele Litos, Peter Hornung, Karl Mechtler and
Stefan Westermann (2012). CENP-T proteins are conserved centromere receptors of
the Ndc80 complex, Nature Cell Biology 14, 604-613
Comment in: Nature Cell Biology 14(6):559-61
Tomasz Zimniak, Veronika Fitz, Hongwen Zhou, Fabienne Lampert, Susanne Opravil,
Karl Mechtler, Peggy Stolt-Bergner and Stefan Westermann (2012). Spatio-temporal
regulation of Ipl1/Aurora activity by direct Cdk1 phoshorylation, Current Biology
22(9):787-793
Fabienne Lampert and Stefan Westermann (2011). A blueprint for kinetochores – new
insights into molecular mechanics of cell division. Nature Rev. Mol. Cell. Biol., 12(7):407-
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Peter Hornung, Michael Meier, Greg Alushin, Gabriel Lander, Eva Nogales and Stefan
Westermann (2011). Molecular architecture and connectivity of the budding yeast Mtw1
kinetochore complex, J.Mol.Biol. 405(2):548-59
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Curriculum vitae
Dr. Stefan Westermann
Fabienne Lampert, Peter Hornung and Stefan Westermann (2010). The Dam1 complex
confers microtubule plus end tracking activity to the Ndc80 kinetochore complex. J.Cell
Biology, 189 (4): 641-649.
In Focus: “Kinetochores hang on for the ride” J.Cell Biology, 189 (4): p 615
Eva Kiermaier, Sophie Woehrer, Yutian Peng and Stefan Westermann (2009). A Dam
1- based artificial kinetochore is sufficient to promote chromosome segregation in
budding yeast. Nature Cell Biology, Sep;11(9):1109-15
Tomasz Zimniak, Katharina Stengl, Karl Mechtler and Stefan Westermann (2009).
Phosphoregulation of the budding yeast EB1 homolog Bim1p by Aurora/Ipl1p. J.Cell
Biology, 186 (3):379-391
Hong-Wei Wang, Sydney Long, Claudio Ciferri, Stefan Westermann, David Drubin,
Georjana Barnes and Eva Nogales (2008). Architecture and Flexibility of the Yeast
Ndc80 kinetochore complex. J. Mol. Biol. 383(4):894-903
E.L. Grishchuk, I.S. Spiridonov, V.A. Volkov, A.Efremov, S.Westermann, D. Drubin,
G.Barnes, J.R. McIntosh and F.L. Ataullakhanov. (2008) The Dam1 ring binds
microtubules strongly enough to be a processive as well as energy-efficient coupler for
chromosome motion . Proc.Natl Acad. Sci 105(40):1423-8
E.L. Grishchuk, I.S. Spiridonov, V.A. Volkov, A.Efremov, S.Westermann, D. Drubin,
G.Barnes, F.L. Ataullakhanov and J.R. McIntosh. (2008) Different assemblies of the
DAM1 complex follow shortening microtubules by distinct mechanisms. Proc.Natl Acad
Sci 105(19): 6918-23
Stefan Westermann: A close look at kinetochore function. Interviewed by Caitlin
Sedwick. J Cell Biol. 2007 December 3; 179(5): 810–811
Wong, J., Nakajima, Y., Westermann, S., Chang, S., Goodner, C., Houshmand., P.,
Fields, S., Drubin, D.G, Barnes., S and Hazbun, T. (2007). A protein interaction map of
the mitotic spindle. Mol Biol Cell, 18(10): 3800-9
Wang, H.-W., Ramey, V.H., Westermann, S., Leschziner, A., Welburn, J.P.I, Nakajima,
Y., Drubin, D.G., Barnes, G. and Nogales, E. (2007). Architecture of the Dam1
kinetochore ring complex: Implications for Microtubule-Driven Assembly and Force-
Coupling Mechansims, Nature Structural and Molecular Biology 14(8): 721-6
Westermann, S., Drubin, D.G. and Barnes, G. (2007). Structures and Functions of
Yeast Kinetochore Complexes Annu. Rev. Biochemistry, (76): 563-91
Westermann, S., Avila-Sakar, A., Wang, H.-W., Drubin, D.G., Nogales, E. and Barnes,
G. (2006) The Dam1 Kinetochore Ring Complex moves processively on depolymerizing
Microtubule ends. Nature 440, 565-569. .
Westermann, S., Avila-Sakar, A., Wang, H.-W., Niederstrasser, H., Wong, J., Drubin,
D.G., Nogales, E. and Barnes, G. (2005) Formation of a dynamic kinetochore-
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Curriculum vitae
Dr. Stefan Westermann
microtubule Interface through assembly of the Dam1 ring complex. Mol. Cell 17, 277-
290.
Comment in Nat Struct Mol Biol. 2005 Mar;12(3):210-2
Curr Biol. 2005 Apr 26;15(8):R299-302
Westermann S, Cheeseman, I.M, Anderson, S., Yates III, J.R., Drubin, D.G. and
Barnes, G. (2003). Architecture of the Budding Yeast Kinetochore reveals a conserved
molecular core. J. Cell Biol. 163, 215-222.
Westermann, S. and Weber, K. (2003). Post-translational modifications regulate
microtubule function. Nature Rev. Mol. Cell. Biol. 4, 938-948
Westermann, S. und Weber, K (2002). Identification of CfNek, a novel member of the
NIMA family of cell cycle regulators, as a polypeptide copurifying with tubulin
glutamylation activity in Crithidia. J.Cell.Sci. 115, 5003-5012
Best paper award 2002 J Cell Sci 2003 116: 1155
Westermann, S. und Weber, K. (2000). Cloning and recombinant expression of the La
RNA-binding protein from Trypanosoma brucei. Biochem.Biophys.Acta 1492, 483-487.
Westermann, S., Schneider, A., Horn, E.K. und Weber, K. (1999). Isolation of Crithidia
tubulin polyglutamylase; binding to microtubules and tubulin, and glutamylation of
mammalian brain a- and b-tubulins. J.Cell Sci. 112, 2185-2193.
Westermann, S., Plessmann, U. und Weber, K. (1999). Synthetic peptides identify the
minimal sequence requirements of tubulin polyglutamylase in side chain elongation.
FEBS Lett. 459, 90-94
Weber, K., Schneider, A., Westermann, S., Müller, N. and Plessmann, U. (1997). Posttranslational
modifications of a- and b-tubulin in Giardia lamblia, an ancient eukaryote.
FEBS Lett. 419, 87-91.
Dörk, T., Westermann, S., Dittrich, O., Twardowski, M., Karstens, J.H., Schmidtke, and
Stuhrmann, M.(1997). A frequent polymorphism of the gene mutated in ataxia
telangiectasia. Mol. Cell. Probes 11, 71-73
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