Laboratory testing for LA
Laboratory testing for LA
Laboratory testing for LA
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Revised classification criteria <strong>for</strong> APS.*<br />
APS is present if at least one of the following (clinical<br />
criteria and one of the) laboratory criteria are met:<br />
2. <strong>Laboratory</strong> criteria<br />
a. <strong>LA</strong> present detected according to ISTH SSC guidelines**<br />
• May soon be challenged by ‘CLSI guidelines’<br />
• What about the British guidelines?***<br />
b. aCL antibody of IgG and/or IgM isotype, present in medium or high titer.<br />
• IgM?<br />
• No standard accepted definition of medium or high titer<br />
c. a 2GPI antibody of IgG and/or IgM isotype.<br />
• IgM?<br />
• No standard accepted definition of medium or high titer<br />
d. aCL & a 2GPI should be “measured by a standardized ELISA according to<br />
recommended procedures”.<br />
• standardized ELISA? No such beast.<br />
* Miyakis et al. JTH 2006;4:295-306<br />
** Pengo et al. JTH 2009;7:1737-40<br />
*** Keeling et al. BJH 2012;157:47-58<br />
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