Laboratory testing for LA
Laboratory testing for LA
Laboratory testing for LA
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Revised classification criteria <strong>for</strong> APS.*<br />
APS is present if at least one of the following clinical<br />
criteria (and one of the laboratory criteria) are met:<br />
1. Clinical criteria<br />
a. Vascular thrombosis:<br />
One or more clinical episodes of arterial, venous, or small vessel thrombosis, in<br />
any tissue or organ. Thrombosis must be confirmed by objective validated criteria.<br />
b. Pregnancy morbidity:<br />
(i) One or more unexplained deaths of a morphologically normal fetus at or<br />
beyond the 10th week of gestation, with normal fetal morphology, or<br />
(ii) One or more premature births of a morphologically normal neonate be<strong>for</strong>e<br />
the 34th week of gestation because of eclampsia, severe preeclampsia, or<br />
placental insufficiency, or<br />
(iii) Three or more unexplained consecutive spontaneous abortions be<strong>for</strong>e the<br />
10th week of gestation, with exclusion of anatomic, hormonal and chromosomal<br />
causes.<br />
* Summarised from Miyakis et al. JTH 2006;4:295-306.<br />
‘APS classification criteria’ to establish ‘definite APS’ <strong>for</strong> inclusion in<br />
research studies; however, popularly used as ‘APS diagnostic criteria’<br />
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