Laboratory testing for LA

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Laboratory testing for LA - Cut-off values for LA pos/neg: ‣ Ratio of screen/confirm: ‣ Most labs probably use 1.2 used as ‘generic’ normalised ratio ‣ Many reagent manufacturers mention a ‘generic’ ratio of 1.2 ‣ ‘Generic’ ratio of 1.2 recently ‘validated’* ‣ Values as low as 1.06 are used by some labs ‣ Too low a value = increase false positive; too high a value = increase false negative. ‣ Alternatives using mixing such as % correction/Rosner index (ICA – index of circulating anticoagulant) ‣ ICA = [(b-c)/a] x 100 (where a, b, c = clotting times of patient, mixture, normal, respectively) ‣ For Rosner index/ICA - local determination of value (generally between 10-20%)** * McGlasson & Fritsma. STH 2013; 39:315-319 ** Kershaw & Orellana. STH 2013;39:283-290 18
Cross laboratory testing of LA (RCPA QAP) Favaloro et al. STH 2012;38:404–11 19
Page 1 and 2: Diagnosing lupus anticoagulants Emm
Page 3 and 4: Dedication Dedicated to memory of P
Page 5 and 6: Talk overview - ‘attack of the ac
Page 7 and 8: APS - more acronyms ‣ PAPS - Prim
Page 9 and 10: Revised classification criteria for
Page 11 and 12: Revised classification criteria for
Page 13 and 14: Laboratory testing for LA: ‣ Two
Page 15 and 16: Laboratory testing for LA - Cut-off
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Page 25 and 26: Laboratory testing for LA - To mix
Page 27 and 28: Laboratory testing for LA - To mix
Page 29 and 30: Laboratory testing for LA - Mix the
Page 31 and 32: Laboratory testing for LA - Mix the
Page 33 and 34: Laboratory diagnosis of LA - Summar
Page 35 and 36: Clinical utility of aPL testing:
Page 37: Acknowledgments ‣ Meeting organis

Laboratory testing for LA

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