Laboratory testing for LA
Laboratory testing for LA
Laboratory testing for LA
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<strong>Laboratory</strong> <strong>testing</strong> <strong>for</strong> <strong>LA</strong> - Cut-off values :<br />
‣ Screen & confirm assay cut-offs:<br />
‣ Support <strong>for</strong> ‘generic’ ratio of (around) 1.2*<br />
‣ 200 normal subjects (40 <strong>for</strong> each of 5 centres)<br />
‣ 6 <strong>LA</strong> functional assays (same procedure, reagent<br />
lot and analyser type at each site).<br />
‣ dRVVT <strong>LA</strong> screen and confirm assays, SCT (silica<br />
clotting time) screen and confirm assays, based on<br />
APTT, with low and high phospholipid content<br />
‣ 2 mixing assays (dRVVT & SCT)<br />
‣ IL reagents/ ACL top<br />
* Pradella et al. Clin Chem Lab Med 2013; 51(2): 379–385<br />
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