Release Notes - Pharsight
Release Notes - Pharsight
Release Notes - Pharsight
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WinNonlin ® 5.3 <strong>Release</strong> <strong>Notes</strong> What’s new in Version 5.3<br />
workbooks created in earlier versions of WinNonlin will also display these Annotation columns<br />
with the new wrap text formatting.<br />
Validation and prediction grids are now saved as separate workbooks (QC 1850): To<br />
improve compatibility with PKS Reporter, the IVIVC Wizard in WinNonlin 5.3 creates two new<br />
workbooks using the output in the validation and prediction grids in the IVIVC Wizard. The new<br />
workbooks are called "Validation Errors.pwo" and "Prediction Errors.pwo."<br />
Descriptive Statistics and the Table Wizard have a new standard deviation option (QC<br />
2407): Users who need to use the 68-95-99.7 rule to calculate standard deviations now have the<br />
option to do so in WinNonlin 5.3. The Descriptive Statistics module and the Table Wizard now<br />
have a Number of S(tandard)D(deviations) option. Also, the Descriptive Statistics module<br />
creates new confidence interval output, which is listed in the User’s Guide.<br />
IVIVC Wizard creates two new plots during deconvolution process (QC 2429): In<br />
WinNonlin 5.3, the IVIVC Wizard creates two new deconvolution plots, "Fa-Avg" and "Fa-Avg<br />
By Profile." Fa-Avg is Fabs (subject * formulation) grouped by subject with Fabs_avg<br />
(formulation) overlaid vs. time, and sorted by formulation. Fa-Avg By Profile is Fabs grouped by<br />
formulation vs. time, and sorted by profile.<br />
NOTE: If a user selects a data set that is already deconvolved and averaged, then these plots are<br />
not created.<br />
The IVIVC Wizard creates a new plot during the correlation phase (QC 2431): In<br />
WinNonlin 5.3, the IVIVC Wizard creates a plot showing Fdis vs. Fabs grouped by formulation.<br />
This new plot is called "Corr Abs vs. Diss."<br />
IVIVC correlation may be validated using mean-observed data (QC 2432): WinNonlin 5.3<br />
provides the option to calculate IVIVC %PE_AUC and Cmax values during the validation and<br />
prediction phases using predicted vs. mean-observed concentration-time data where arithmetic<br />
means are generated directly from the user-supplied observed data.<br />
WinNonlin 5.3 supports Microsoft Windows Vista (QC 2557): WinNonlin now supports the<br />
32-bit version of Windows Vista.<br />
WinNonlin 5.3 supports Microsoft Office 2007 (QC 2574): WinNonlin now supports Office<br />
2007.<br />
WinNonlin 5.3 uses the same licensing system as Phoenix 1.x (QC 2576): Earlier versions of<br />
WinNonlin were using version 6.0 of the Sentinel license management system. WinNonlin 5.3<br />
has been upgraded to use the same version as Phoenix 1.x, namely 8.1.1, of this system.<br />
WinNonlin 5.3 supports Microsoft Windows 7 (QC 2578, 2582): WinNonlin now supports<br />
64-bit and 32-bit versions of Windows 7.<br />
Revision 0 Page 2 of 16 December 2009