Release Notes - Pharsight

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WinNonlin ® 5.3 Release Notes Known issues in Version 5.3 is floating, installed on a Floating License Server that has non-English characters in the ASCII name, and the WinNonlin® client machine uses that name as its host name. The workaround is to use the IP address of the license server instead of the DNS name. In an NCA model if the Y-variable, such as concentration, has a missing value at time 0 the carry-along information is not displayed at time 0 in the Summary Table worksheet (QC 1525): Carry-along variables in an NCA model are not displayed in the Summary Table for time 0 if the source data has a missing Y-value at time 0 or there is no observation at time 0 in the data set. For other time points the carry-along variables are displayed correctly. Refresh All option not working for Deconvolution (QC 1734): It does not record the Exclusions in the History Tab. Uninstalling WinNonlin (QC 1739): Uninstalling WinNonlin does not delete all files from the Pharsight/WinNonlin folder. Linear Mixed Effects in WinNonlin® is case-insensitive (QC 1790): The Linear Mixed Effects wizard in WinNonlin® cannot differentiate between upper and lower cases in input data sources. For example, if AA and aa are used as subject identifiers, only AA is shown in the output. The workaround is to not use lower and upper case to differentiate between variables values in a data set. PKS error message (QC 1922): When using WinNonlin® with PKS 3.0 and a dataset that has different Treatment Descriptions for the same Treatment, an error message might result. For example, if Treatment = A throughout the dataset, but the associated Treatment Descriptions are IV and Extravascular, an error message occurs. This issue does not occur when using WinNonlin with PKS versions 3.1 and later. Script error message is displayed when printing certain online help headings and subtopics (QC 1985): When selecting to print the selected heading and all subtopics, an Internet Explorer Script Error message is displayed. However, despite this error, help prints without any errors. Merge output includes excluded data (QC 2002): The merge output produces output that contains excluded rows and data from the original input workbooks. Modeling Error 10998 intermittently occurs when opening files directly from a .zip file (QC 2035): Extracting the file from the zip file first and then opening it solves the issue at first, but if you try to re-open the file again from the zip file, the error occurs again. No units are carried through the NCA calculations when all concentrations are 0 (QC 2042, ONYX 49088): When running noncompartmental analyses for a profile where all concentrations for a subject are 0, a warning message is displayed that units might be wrong, Cmax is set to 0 (which is correct), and all other parameters are reported as "missing" (which is also correct). All Revision 0 Page 8 of 16 December 2009
WinNonlin ® 5.3 Release Notes Known issues in Version 5.3 results (whether 0 or missing) are contained in the "non-transposed final parameters" sheet, but all units are missing. Missing values when Disable curve stripping is selected (QC 2162): If "Disable curve stripping" is selected before Baseline values are entered, missing values on the Final Parameters tab can occur. WinNonlin® and PKS GUI field names differ (QC 2235): In WinNonlin® the Dose attribute “Route” is displayed as Analytical Method, whereas PKS displays the same attribute as Route. In addition, the Treatment attribute in PKS is displayed as Treatment Code in WinNonlin®. Missing time points plotted incorrectly (QC 2237): Missing time points are plotted for Lambda Z as zero values. Model options default output option changes (QC 2252): If you change another global setting, defined in Tools > Options, the global setting for text output is changed to unselected. Workaround is to change the global settings by selecting the option for text output. Professional license error message (QC 2289): With a new installation of WinNonlin®, even with a Professional license installed, the error message, “You are using this product without a registered license,” is displayed when opening WinNonlin®. This message is displayed for the first 30 days after installation, during which time the 30-day trial license to the Enterprise edition is valid. Create study requires workaround when mapping time unit to a column (QC 2302): Workaround involves mapping time unit first. 2316, CRM 49405 Special case where AUClast is reported as missing (QC 2316): For NCA models 200 and 202, if there is only one non-zero value and that value does not occur at dosing time, then AUCall is reported, but AUClast is missing even though it can be computed. The workaround is to obtain AUClast from the Summary Table worksheet. Superfluous error message in text output when another error occurs (QC 2349): When an error occurs in Modeling, an extra error message, Error 10161, Inadequate System Resources Available for this Problem, might also be displayed in the text output file. The Increment for Partial Derivatives entry field is not enabled correctly, so the default value is always used (QC 2351): If a user enters a different value in the Increment for Partial Derivatives entry field in the Settings tab of the Model Options dialog, and saves the model as a .pmo file, then partial derivatives reverts to its default value when the .pmo file is loaded. The workaround is to use the DINCREMENT command in ASCII model format. File open dialog does not default to file type of pre-populated filename (QC 2392): File open dialog defaults to last file type opened instead. Revision 0 Page 9 of 16 December 2009
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Release Notes - Pharsight

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