CAFEINE CAS : 58-08-2 - UNEP Chemicals

More documents

Recommendations

Info

OECD SIDS CAFFEINE 5. TOXICITY DATE: 04-MAR-2003 SUBSTANCE ID: 58-08-2 Route of admin.: i.v. Value: = 105 mg/kg bw Method: other: no data GLP: no data Test substance: other TS Test substance: caffeine 29-AUG-2000 (72) 5.2 Corrosiveness and Irritation 5.2.1 Skin Irritation Species: rabbit Concentration: 50 % Exposure: Semiocclusive Exposure Time: 4 hour(s) No. of Animals: 3 PDII: 0 Result: not irritating EC classificat.: not irritating Method: OECD Guide-line 404 "Acute Dermal Irritation/Corrosion" Year: 1981 GLP: no Test substance: as prescribed by 1.1 - 1.4 Remark: Two male and one female White Vienna rabbits were applied ca. 500 mg of the test substance (a 50% (w/w) aqueous formulation) for 4 hours under semiocclusive conditions. After 4 hours, the application patches were removed, and the application sites were washed with water and Lutrol/water (1/1). The skin was scored at 30-60 minutes after removal of the patches and at 24, 48, and 72 h. No signs of irritation were observed; irritation indices (erythema and edema) were 0 in each animal at each reading time. Reliability: (1) valid without restriction guideline study (OECD) Flag: Critical study for SIDS endpoint 06-DEC-2001 (85) 5.2.2 Eye Irritation Species: rabbit Concentration: undiluted Dose: .1 ml Comment: not rinsed No. of Animals: 3 Result: not irritating EC classificat.: not irritating Method: OECD Guide-line 405 "Acute Eye Irritation/Corrosion" 106 UNEP PUBLICATIONS
OECD SIDS CAFFEINE 5. TOXICITY DATE: 04-MAR-2003 SUBSTANCE ID: 58-08-2 Year: 1981 GLP: no Test substance: as prescribed by 1.1 - 1.4 UNEP PUBLICATIONS 107
Page 1 and 2:
OECD SIDS CAFFEINE FOREWORD INTRODU
Page 3 and 4:
OECD SIDS CAFFEINE lead company BAS
Page 5 and 6:
OECD SIDS CAFFEINE Caffeine metabol
Page 7 and 8:
OECD SIDS CAFFEINE FULL SIDS SUMMAR
Page 9 and 10:
OECD SIDS CAFFEINE 5.9 Developmenta
Page 11 and 12:
OECD SIDS CAFFEINE 1 IDENTITY SIDS
Page 13 and 14:
OECD SIDS CAFFEINE Caffeine is prod
Page 15 and 16:
OECD SIDS CAFFEINE The elimination
Page 17 and 18:
OECD SIDS CAFFEINE Case reports and
Page 19 and 20:
OECD SIDS CAFFEINE 3.1.1.5.2 Low bi
Page 21 and 22:
OECD SIDS CAFFEINE Based on two coh
Page 23 and 24:
OECD SIDS CAFFEINE No valid data av
Page 25 and 26:
OECD SIDS CAFFEINE 3.1.6 Genetic To
Page 27 and 28:
OECD SIDS CAFFEINE There were no st
Page 29 and 30:
OECD SIDS CAFFEINE Task 3 (crossove
Page 31 and 32:
OECD SIDS CAFFEINE 3.1.9 Developmen
Page 33 and 34:
OECD SIDS CAFFEINE schedule) were r
Page 35 and 36:
OECD SIDS CAFFEINE 5 Conclusions an
Page 37 and 38:
OECD SIDS CAFFEINE Workplace: Takin
Page 39 and 40:
OECD SIDS CAFFEINE (00/0360/21/1),
Page 41 and 42:
OECD SIDS CAFFEINE Goldstein A., Wa
Page 43 and 44:
OECD SIDS CAFFEINE Maihles J. B. et
Page 45 and 46:
OECD SIDS CAFFEINE Rivenes S.M., et
Page 47 and 48:
OECD SIDS CAFFEINE Date of the lite
Page 49 and 50:
OECD SIDS CAFFEINE Existing Chemica
Page 51 and 52:
OECD SIDS CAFFEINE 1. GENERAL INFOR
Page 53 and 54:
OECD SIDS CAFFEINE 1. GENERAL INFOR
Page 55 and 56: OECD SIDS CAFFEINE 1. GENERAL INFOR
Page 61 and 62: OECD SIDS CAFFEINE 2. PHYSICO-CHEMI
Page 69 and 70: OECD SIDS CAFFEINE 3. ENVIRONMENTAL
Page 77 and 78: OECD SIDS CAFFEINE 4. ECOTOXICITY D
Page 89 and 90: OECD SIDS CAFFEINE 5. TOXICITY DATE
Page 105: OECD SIDS CAFFEINE 5. TOXICITY DATE
Page 157 and 158:
OECD SIDS CAFFEINE 5. TOXICITY DATE
Page 159 and 160:
Page 161 and 162:
Page 163 and 164:
Page 165 and 166:
Page 167 and 168:
Page 169 and 170:
Page 171 and 172:
Page 173 and 174:
Page 175 and 176:
Page 177 and 178:
Page 179 and 180:
Page 181 and 182:
Page 183 and 184:
Page 185 and 186:
Page 187 and 188:
Page 189 and 190:
Page 191 and 192:
Page 193 and 194:
Page 195 and 196:
Page 197 and 198:
Page 199 and 200:
Page 201 and 202:
Page 203 and 204:
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
Page 211 and 212:
Page 213 and 214:
Page 215 and 216:
Page 217 and 218:
Page 219 and 220:
Page 221 and 222:
Page 223 and 224:
Page 225 and 226:
Page 227 and 228:
Page 229 and 230:
Page 231 and 232:
Page 233 and 234:
Page 235 and 236:
Page 237 and 238:
Page 239 and 240:
Page 241 and 242:
Page 243 and 244:
Page 245 and 246:
Page 247 and 248:
Page 249 and 250:
Page 251 and 252:
Page 253 and 254:
Page 255 and 256:
Page 257 and 258:
Page 259 and 260:
Page 261 and 262:
Page 263 and 264:
Page 265 and 266:
Page 267 and 268:
Page 269 and 270:
Page 271 and 272:
Page 273 and 274:
Page 275 and 276:
Page 277 and 278:
Page 279 and 280:
Page 281 and 282:
Page 283 and 284:
Page 285 and 286:
Page 287 and 288:
Page 289 and 290:
Page 291 and 292:
Page 293 and 294:
Page 295 and 296:
Page 297 and 298:
Page 299 and 300:
Page 301 and 302:
Page 303 and 304:
Page 305 and 306:
Page 307 and 308:
Page 309 and 310:
Page 311 and 312:
Page 313 and 314:
Page 315 and 316:
Page 317 and 318:
Page 319 and 320:
Page 321 and 322:
Page 323 and 324:
Page 325 and 326:
Page 327 and 328:
Page 329 and 330:
OECD SIDS CAFFEINE 6. ANALYT. METH.
Page 331 and 332:
OECD SIDS CAFFEINE 8. MEAS. NEC. TO
Page 333 and 334:
OECD SIDS CAFFEINE 9. REFERENCES DA
Page 335 and 336:
Page 337 and 338:
Page 339 and 340:
Page 341 and 342:
Page 343 and 344:
Page 345 and 346:
Page 347 and 348:
Page 349 and 350:
Page 351 and 352:
Page 353 and 354:
Page 355 and 356:
Page 357 and 358:
Page 359 and 360:
Page 361 and 362:
Page 363 and 364:
Page 365 and 366:
Page 367 and 368:
Page 369 and 370:
Page 371 and 372:
Page 373 and 374:
Page 375 and 376:
show all

CAFEINE CAS : 58-08-2 - UNEP Chemicals

Create successful ePaper yourself

Delete template?

Save as template?