CAFEINE CAS : 58-08-2 - UNEP Chemicals

OECD SIDS CAFFEINE
5. TOXICITY DATE: 04-MAR-2003
SUBSTANCE ID: 58-08-2
containing the test substance for 6 weeks. According to the
authors, average daily intake of the test substance was ca.
3.86 mg/rat. Examination of the pancreas revealed no
substance-related effect on organ weight or DNA, RNA and
protein content while the number of zymogen granules was
slightly increased. Amylase, immunoreactive cationic
trypsin(ogen), and trypsinogen was elevated in pancreatic
homogenate while seerum levels of immunoreactive cationic
trypsin(ogen) and amylase were lower than control.
The rate of secretion of amylase, trypsin and chymotrypsin was
singificantly lower than in controls in response to CCK-8
and nicotine. Leucine incorporation was significantly
elevated in acini in the treated rats in the presence of
CCK-8, secretin and carbachol.
Test substance: caffeine
Reliability: (4) not assignable
secondary literature
06-DEC-2001 (88)
Species: rat Sex: female
Strain: no data
Route of administration: drinking water
Exposure period: before and during pregnancy and during lactation
Frequency of treatment: continuously in the drinking water
Post exposure period: none
Doses: ca. 36 mg/kg/d (0.04% in the drinking water)
Method: other: no data
Year: 1990
GLP: no data
Test substance: other TS
Result: The aim of the study was to investigate the effect of
maternal caffeine uptake on the tyrosine level in neonatal
cerebrum. Dams were administered the test substance at a
concentration of 0.04% in the drinking water before and/or
during gestation and during lactation. Free amino acids in
the cerebrum of the neonates were examined on days 1, 5, and
10 post partum. The tyrosine concentration was increased in
the cerebrum (days 1 and 5, with approximate mean caffeine
levels of above 1.5-2.0 ug/g wet weight), but not in the
liver. The tyrosine level showed a positive correlation with
the caffeine level in neonates only on day 1 in the group
administered the test substance after pregnancy. There was
no significant increase in the fetal cerebral concentration
of MOPEG-sulfate. According to the authors, these results
suggested that maternal caffeine uptake of the test
substance disturbed the neonatal cerebrum through tyrosine
and thyrosine hyroxylase and then produced behavioural
changes in developing rats.
Test substance: caffeine
Reliability: (4) not assignable
secondary literature
06-DEC-2001 (89)
110
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