CAFEINE CAS : 58-08-2 - UNEP Chemicals

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OECD SIDS CAFFEINE 5. TOXICITY DATE: 04-MAR-2003 SUBSTANCE ID: 58-08-2 Remark: In a retrospective study the drug consumption during pregnancy with congenital abnormalities in infants was examined in 1,369 mothers. In mothers taking caffeine no increased numbers of congenital abnormalities in infants were observed. reproductive toxicity (birth defects) 19-FEB-2001 (541) 300 UNEP PUBLICATIONS
OECD SIDS CAFFEINE 5. TOXICITY DATE: 04-MAR-2003 SUBSTANCE ID: 58-08-2 Remark: In a case-control study of 2,030 malformed infants, six selected birth defects were evaluated in relation to maternal ingestion of caffeine intake during pregnancy. 380 infants with inguinal hernia, 299 with cleft lip, 277 with cardiac defetcs, 194 with pyloric stenosis, 120 with isolated cleft palate, and 101 with neural tube fusion defects were compared to 712 other malformed infants who served as control. None of the point estimates of relative risk was significantly greater than unity. reproductive toxicity (birth defects) 13-MAR-2001 (542) Remark: 755 pairs of mothers of malformed children and their controls were studied to examine an association between coffee consumption and malformations. The coffee consumption during pregnancy was similar for the mothers of malformed or non-malformed children. The comparison of the mothers drinking at least four cups of coffee a day during pregnancy with those not consuming coffee at all showed a RR of 1.0 (95% CI 0.7-1.3). reproductive toxicity (birth defects) 13-FEB-2001 (543) Remark: reproductive toxicity (birth defects) Retrospective information on maternal caffeine intake during pregnancy and abnormal offspring was obtained by questionnaire during 1989. 14 cases were examined. Spontaneous abortion or stillbirth was associated with high level of caffeine consumption (about 1,000 mg) each day. Low birth weight infants or premature birth infants were caused by caffeine intake >200 mg a day. Developmental delay or central nervous system dysfunction was also associated with caffeine intake >200 mg a day. Congenital anomalies were noted also with >200 mg caffeine per day. 27-FEB-2001 (544) Remark: Interviews and medical-record data of 12,205 were analysed to evaluate the relationshipbetween coffe consumption and adverse outcomes of pregnancy. After controlling for smoking, other habits, demographic characteristics, and medical history no relation between low birth weight or short gestation and heavy coffee consumption was found. Furthermore there was no excess of malformations among coffee drinkers. reproductive toxicity (birth defects) 13-MAR-2001 (545) Remark: A large North American study followed 5378 women exposed during pregnancy to caffeine-containing drugs for possible malformations in their offspring. For all malformations considered together (n=350) the RR was 0.98. For malformations at individial sites, the RRs ranged from 0.70 to 1.2 (nonsignificant). reproductive toxicity (birth defects) 20-AUG-2001 (546) UNEP PUBLICATIONS 301
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OECD SIDS CAFFEINE FOREWORD INTRODU
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OECD SIDS CAFFEINE lead company BAS
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OECD SIDS CAFFEINE Caffeine metabol
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OECD SIDS CAFFEINE FULL SIDS SUMMAR
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OECD SIDS CAFFEINE 5.9 Developmenta
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OECD SIDS CAFFEINE 1 IDENTITY SIDS
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OECD SIDS CAFFEINE Caffeine is prod
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OECD SIDS CAFFEINE The elimination
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OECD SIDS CAFFEINE Case reports and
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OECD SIDS CAFFEINE 3.1.1.5.2 Low bi
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OECD SIDS CAFFEINE Based on two coh
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OECD SIDS CAFFEINE No valid data av
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OECD SIDS CAFFEINE 3.1.6 Genetic To
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OECD SIDS CAFFEINE There were no st
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OECD SIDS CAFFEINE Task 3 (crossove
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OECD SIDS CAFFEINE 3.1.9 Developmen
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OECD SIDS CAFFEINE schedule) were r
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OECD SIDS CAFFEINE 5 Conclusions an
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OECD SIDS CAFFEINE Workplace: Takin
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OECD SIDS CAFFEINE (00/0360/21/1),
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OECD SIDS CAFFEINE Goldstein A., Wa
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OECD SIDS CAFFEINE Maihles J. B. et
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OECD SIDS CAFFEINE Rivenes S.M., et
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OECD SIDS CAFFEINE Date of the lite
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OECD SIDS CAFFEINE Existing Chemica
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OECD SIDS CAFFEINE 1. GENERAL INFOR
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OECD SIDS CAFFEINE 3. ENVIRONMENTAL
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CAFEINE CAS : 58-08-2 - UNEP Chemicals

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