CAFEINE CAS : 58-08-2 - UNEP Chemicals

OECD SIDS CAFFEINE
5. TOXICITY DATE: 04-MAR-2003
SUBSTANCE ID: 58-08-2
role.
toxic effects (tolerance and withdrawl, review)
01-MAR-2001 (437)
Remark: toxic effects (tolerance and withdrawl)
Twenty healthy volunteers paricipated a study to
investigate whether measurable changes in cerebral blood
flow velocities could develop from caffeine use or from its
withdrawl.
After 24 h of complete caffeine abstinence 10 suffered from
moderate to severe headache with complete recovery within 1
h after caffeine intake. The BFVs in both middle cerebral,
both posterior cerebral and basilar arteries were higher
following the withdrawl period, reaching statistical
significance in the left middle cerebral basilar and both
posterior posterior arteries. BFVs decreased significantly
within half an hour after caffeine intake in all subjects,
and were simmilar to baseline values after 2 hours.
14-MAR-2001 (438)
Remark: Review of medical literature on fibrocystic breast disease
and caffeine intake indicated a weak evidence for an
association.
toxic effects (benign breast disease, review)
15-FEB-2001 (439)
Remark: Overview: benign breast disease in relation to caffeine and
other methylxanthines (case series, intervention in trials
and etiological studies).
There is controversy about the role of caffeine in benign
fibrocystic breast disease (FDB). Some investigators
associate caffeine with FBD, since the substance is a
phosphordiesterase inhibitor and increases the cAMP level
(which stimulates epithelial proliferation and high levels
of which are found in benign breast tissue). Many other
authors fail to find a significant correlation between
caffeine (or coffee) intake and FBD. Several factors are
responsible for the inconsistencies in the results. These
factors include unknown precise cause of FBD, variability
in diagnosis, difficulties in matching controls and
classifying patients, and mixed intake of several
methylxanthines. No association was found in a study with
biopsy-confirmed controls.
toxic effects (benign breast disease, review)
20-FEB-2001 (331) (440)
Remark: The relation of coffee and tea consumption to fibrocystic
disease of the breast and to breast cancer was studied in
451 women hospitalized. A modest, positive association
between caffeinated beverage consumption and both diseases
was found. However, there was no apparent dose-response
effect.
toxic effects (benign breast disease)
15-FEB-2001 (441)
Remark: In a case-control study with 323 women with beningn breast
disease and 1,428 controls, no differences were noted in
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