CAFEINE CAS : 58-08-2 - UNEP Chemicals

OECD SIDS CAFFEINE
5. TOXICITY DATE: 04-MAR-2003
SUBSTANCE ID: 58-08-2
202
mice.
According to the authors, these results suggested that
caffeine consumption enhanced mammary tumorigenesis in C3H
and carcinogen-treated BD2F mice and enhanced developmental
growth of normal BALB/c mouse mammary gland.
Test substance: caffeine
Reliability: (2) valid with restrictions
17-DEC-2001 (272) (273)
Species: mouse Sex: female
Strain: other: C3H/He, GR/A, SHN, SLN
Route of administration: drinking water
Exposure period: 20 to 130 days
Frequency of treatment: continuously in the drinking water
Post exposure period: none
Doses: ca. 100 mg/kg/d (0.05% in the drinking water)
Control Group: yes, concurrent no treatment
Method: other: no data
Year: 1987
GLP: no data
Test substance: other TS
Remark: initiation/promotion study
Result: The formation of precancerous mammary hyperplastic alveolar
nodules (HAN) was studied in four strains of mice with
varying mammary tumor potentials. Beginning at 21 days of
age at weaning, the mice were administered tap water
containing 0 or 0.05% of the test substance and were
sacrificed at days 40, 60, 90, 120, and 150 days of age. HAN
appeared at 90, 60, 60, and 120 days in C3H/He, GR/A, SHN,
and SLN mice, respectively. The difference from controls in
the number of HAN was statistically significant in the
C3H/He mice only. The onset of time of HAN was associated
with mammary tumor potential of virgin mice.
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