oxidants and antioxidants in biology - Oxygen Club of California

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Thioredoxin Binding Protein TBP-2/VDUP1: Involvement in Cell Cycle and Aging YUMIKO NISHINAKA 1 , AHSAN MD. KAIMUL 2 , HIROSHI MASUTANI 1, 2 , TOHRU YOSHIDA 2 , MICHIYUKI MAEDA 3 , AND JUNJI YODOI 1,2 1 Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Midorigaoka, Ikeda, Osaka 563-8577, Japan; 2 Department of Biological Responses, Institute for Virus Research, Kyoto University, 5; 3 Shogoin, Kawahara-cho, Sakyo, Kyoto 606-8507, Japan; 3Institute for Frontier Medical Sciences, Kyoto University, 53 Shogoin, Kawahara-cho, Sakyo, Kyoto 606-8507, Japan Thioredoxin (TRX) is one of the vital components of the thiol reducing system and plays multiple roles in cellular processes such as gene expression, cell proliferation and apoptosis. TRX expression is induced by a variety of oxidative stimuli, including UV irradiation, inflammatory cytokines or chemical carcinogens. We have identified TRX binding protein-2 (TBP-2), identical to vitamin D3 up-regulated protein 1 (VDUP1) as a negative regulator of TRX on its expression and reducing activity (1). Expression of TBP-2 is lost in HTLV-I-positive IL-2- independent T-cell lines, but maintained in HTLV-I-positive IL-2- dependent T-cell lines as well as HTLV-I-negative T-cell lines. Ectopic overexpression of TBP-2 in HTLV-I-positive T-cells resulted in growth suppression accompanied by a decrease of TRX reducing activity. In the TBP-2-overexpressing cells, G1 arrest was observed in association with an increase of p16 expression and reduction of Rb phosphorylation. The results suggest that TBP-2 plays a crucial role in the growth regulation of T-cells through the interaction with its target molecules including TRX. Therefore, loss of TBP-2 expression may be involved in the multistep oncogenic process of HTLV-I transformation. The modulation of TRX functions may be a new therapeutic strategy for the treatment of HTLV- I related diseases (2). We have shown that TRX overexpressed mice show a significant resistancy against variety of oxidative stresses, showing increased longevity (3). As TBP-2 is a negative regulator of TRX, we 18
hypothesize that TBP-2 expression is involved in the aging process as well. The TRX-TBP-2 interaction may be an important redox regulatory mechanism in cellular aging processes. References 1. Nishiyama A. et al., J. Biol. Chem., 1999 2. Nishinaka Y. & Nishiyama A. et al. submitted 3. Mitsui A et al., Antioxid Redox Signal. 2002 19
Page 1 and 2: Oxygen Club of California OXIDANTS
Page 3: CONTENTS KEYNOTE ADDRESS...........
Page 6 and 7: The antioxidant network: From scave
Page 9 and 10: SESSION I REDOX REGULATION OF CELL
Page 11 and 12: Bcl-2 expression to promote mitocho
Page 13 and 14: The zinc-finger domains of kinases
Page 15 and 16: Proinflammatory and proapoptotic ef
Page 17: Novel functions of the mammalian cy
Page 22 and 23: Characteristics of channel formatio
Page 24 and 25: Mitochondria in nitric oxide-induce
Page 26 and 27: Mitochondrial nitric oxide synthase
Page 28 and 29: Mitochondria, proteolysis, calcium,
Page 30 and 31: Mitochondria and signaling lipids i
Page 32 and 33: Mitochondrial regulation of apoptot
Page 34 and 35: NADH-dehydrogenase as a marker of a
Page 36 and 37: Mitochondrial reactive oxygen speci
Page 38 and 39: The beneficial effects of fruit pol
Page 40 and 41: Cell signaling and apoptosis in agi
Page 42 and 43: Caloric restriction, gene expressio
Page 44 and 45: Conclusions: Our results have provi
Page 46 and 47: Selective mesurement of nitric oxid
Page 48 and 49: Nitric oxide derived oxidants and c
Page 50 and 51: Nitric oxide (NO) mimics hypoxia by
Page 52 and 53: We are currently trying to exploit
Page 54 and 55: Free radicals produced in exhaustiv
Page 56 and 57: Contraction-induced oxidants as med
Page 58 and 59: Exercise and NF B Signaling in Rat
Page 60 and 61: Chlorophyll fluorescence: A reporte
Page 62 and 63: Role of reactive oxygen species, ni
Page 64 and 65: Oxidative stress, antioxidants, and
Page 66 and 67: Action of Vitamin E against Stress
Page 68 and 69:
Metabolism of tocopherols and tocot
Page 70 and 71:
Vitamin E prevents foam cell format
Page 72 and 73:
Tocotrienols: their effect on immun
Page 74 and 75:
Cloning of novel human SEC14p-like
Page 76 and 77:
or absence of LPS, increased NF-κB
Page 79 and 80:
SESSION VIII VITAMIN E AND SELENIUM
Page 81 and 82:
Antioxidant role of selenium: Relev
Page 83:
Expression of nuclear PHGPx MATILDE
Page 86 and 87:
Carotenoid conversion to Vitamin A:
Page 88 and 89:
Noninvasive laser Raman detection o
Page 90 and 91:
Carotenoids and cancer prevention U
Page 92 and 93:
Cytoprotective and cytotoxic effect
Page 94 and 95:
Flavan-3-ols and procyanidins: beyo
Page 96 and 97:
Effect of genistein and daidzein on
Page 98 and 99:
The antiatherogenic and anti-inflam
Page 100 and 101:
Transcription factor switching by c
Page 103 and 104:
POSTERS
Page 105 and 106:
trols. Their plasma levels of liver
Page 107 and 108:
The reduction of Coenzyme Q 9 at th
Page 109 and 110:
Comparison of antioxidant activitie
Page 111 and 112:
Mn was higher in hepatitis B carrie
Page 113 and 114:
Increased superoxide generation is
Page 115 and 116:
Kidney Mitochondrial Nitric Oxide S
Page 117 and 118:
Thapsigargin induced apotosis ocurr
Page 119 and 120:
Amyloid- and H 2 O 2 induced impair
Page 121 and 122:
Vitamin E recommended daily intake
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Ischemic preconditioning attenuates
Page 125 and 126:
Differential zonal distribution of
Page 127 and 128:
In vitro antioxidant profile of pol
Page 129 and 130:
Oncolyn Neutralizes the Oxidative D
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Can insulin have a neuroprotective
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Antioxidant defense of Trypanosoma
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Evidence for a novel neuroprotectiv
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Cell type dependence in NF- B activ
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Signals that activate hepatic exerc
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Induction of vascular endothelial g
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Ascorbic acid decreases uva-induced
Page 145 and 146:
Lowering of NO stores in patients w
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The possible role of NADP + -depend
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the similar kind of influence conce
Page 151 and 152:
Molecular study of the peroxisomal
Page 153 and 154:
Antioxidant activity of polyphenols
Page 155 and 156:
Nitric oxide mediates the up-regula
Page 157 and 158:
Antioxidant enzymes in purified chl
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Dietary supplementation of essentia
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Time-course of rosmarinic acid prod
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Moderate exercise increases lifespa
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Doxorubicin activates nuclear facto
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In vitro antioxidative properties o
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Radical scavenging activity of dihy
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Enzymatic reduction of glutathione
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Biomarker responses in the clam, Sc
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Analysis of Aminochromes by HPLC-Ph
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Applications of flow cytometry in t
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Key role of xanthine oxidase in wea
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Formation of free radicals in the s
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The role of oxidative stress and an
Page 185 and 186:
Progress towards the discovery of t
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Oxidation derived metabolites of -c
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The Uptake of Tocopherols by RAW 26
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Acute phase immune response to exer
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Relationships between antioxidants
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Antioxidant activity in extracts fr
Page 197 and 198:
Lipid oxidation products with high
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Status of antioxidant defense syste
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Oral administration of Crataegus ex
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A Abdelmohsen, K...................
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Gómez, M........................63
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O Obermueller-Jevic, U.............
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Yanshu, Z..........................
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OCC-CÁDIZ FISCAL SOCIETY PRESIDENT
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