Applying Biomarker Information To Support Drug Discovery ... - IIR

More documents

Recommendations

Info

Anatomic Differences in Brain between Rodent & Primate NA: Nucleus accumbens (reward-motivated actions) Amyg: Amygdala (affective regulation of memory) HIP: Hippocampus (memory consolidation) PFC: prefrontal cortex (working memory and executive function) Amy F.T. Arnsten et al. Trends in Mol. Med.
Mechanistic Pharmacology Platform in <strong>Support</strong> <strong>Drug</strong> Candidate Selection – Cognition Improvement (CNS) • Screen Model testing NOR-test : rodent • Agnosia Model Testing NOR- aged rodent NOR- scopolamine challenge: rodent. • Spatial Memory Testing MWM- aged rodent MWM- scoploamine challenge: rodent and/or primate • Executive Function Testing DMTP- scopolamine challenge (rodent) DMTP- aged primate: primate
Page 1 and 2: Applying Biomarker Information To S
Page 3 and 4: Definition: Surrogate Endpoint A bi
Page 5 and 6: Develop a New Therapy • Strong Me
Page 7 and 8: PK Profiles of IFN / PEG-IFN in Rat
Page 9 and 10: Comparison of Pharmacokinetic Profi
Page 11 and 12: Good Correlation between Predicted
Page 13 and 14: Good Correlation between Model Pred
Page 15 and 16: Good Correlation between Model Pred
Page 17: Findings of PKA Signaling Pathway P
Page 21 and 22: Graphic Illustration -- Mechanism o
Page 23 and 24: Model Prediction vs Literature Valu
Page 25 and 26: Effect of PEG-G & Filgrastim on ANC
Page 27 and 28: Mean BFU-E Colony Formation Profile
Page 29: Acknowledgment PEGSYS Project: PKA

Applying Biomarker Information To Support Drug Discovery ... - IIR

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?