Applying Biomarker Information To Support Drug Discovery ... - IIR
Applying Biomarker Information To Support Drug Discovery ... - IIR
Applying Biomarker Information To Support Drug Discovery ... - IIR
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The Significance of High Degree<br />
Surrogacy <strong>Information</strong><br />
Predicted vs Observed Clin. Resp. with PEG-IFN (5KD)<br />
(data based upon 24 week treatment)<br />
ALT Normalization (%)<br />
150<br />
100<br />
50<br />
0<br />
Observation<br />
Prediction<br />
3M 6M 9M 3M 6M<br />
qw qw qw biw tiw<br />
Predicted Clin. Resp. (%)<br />
r 2 = 0.99<br />
p < 0.001<br />
Observed Clinical Response (%)
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