B Positive – all you wanted to know about - ASHM
B Positive – all you wanted to know about - ASHM
B Positive – all you wanted to know about - ASHM
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THE ROLE OF<br />
COMPLEMENTARY MEDICINE<br />
IN HEPATITIS B<br />
Ses J Salmond Drug and Alcohol Clinical Services, Hunter New England Area Health Service, Arkana Therapy Centre<br />
and Leichhardt Women’s Community Health Centre, NSW.<br />
Robert Batey Drug and Alcohol Services, North Sydney Central Coast Area Health, Wyong Hospital, NSW.<br />
KEY POINTS<br />
� flavonoids isolated from the following plants have demonstrated anti-HbV activity in various in<br />
vitro and in vivo models: wogonin (scutellaria baicalensis) and apigenin (ocinum basilicum).<br />
� a multicentre study of chronic hepatitis b patients found that two different oxymatrine<br />
preparations administered for 24 weeks improved HbV dna clearance compared <strong>to</strong> placebo<br />
(p = 0.001). a randomised, double blind placebo controlled clinical trial of cpd 861 for 24<br />
weeks in chronic hepatitis b patients with fibrosis and early cirrhosis found that the over<strong>all</strong><br />
reversal rate in the grade of fibrosis was 52% in the cpd 861 group compared <strong>to</strong> 20% in<br />
the placebo (p < 0.05). this effect was more pronounced in those with more advanced<br />
fibrosis. Herbal medicines with well documented evidence of hepa<strong>to</strong><strong>to</strong>xicity are: teucrium<br />
chamaedrys (w<strong>all</strong> germander) and teucrium polium, Mentha pulgeium (pennyroyal)<br />
atractylis gummifera (pine thistle) (current name carlina gummifera), certain pyrrolizidine<br />
alkaloids and Larrea tridenta (chapparal).<br />
� Patients with chronic hepatitis b virus infection interested in pursuing complementary medicine<br />
are advised <strong>to</strong> consult an accredited practitioner of traditional chinese medicine or western herbal<br />
medicine or naturopathy. Qualified practitioners can be found at: australian acupuncture and<br />
chinese Medicine association (aacMa) at www.acupuncture.org.au or phone 07 3324 2599 or the<br />
national Herbalists association of australia (nHaa) at www.nhaa.org.au or phone 02 8765 0071.<br />
complementary and alternative medicine<br />
(caM) is increasingly used by the public in<br />
par<strong>all</strong>el with, and instead of conventional<br />
medicine. 1 approximately half of the australian<br />
population use caM <strong>to</strong>t<strong>all</strong>ing an estimated<br />
a$2.3 billion in expenditure in 2000, almost<br />
four times the public contribution <strong>to</strong> <strong>all</strong><br />
pharmaceuticals. 2 these local figures represent<br />
a 120% increase in the use of caM products<br />
and a 63% increase in expenditure on caM<br />
therapists respectively since 1993. 2 in 2004,<br />
the <strong>to</strong>tal expenditure fell <strong>to</strong> a$1.3 billion on<br />
caM products and <strong>to</strong> a$494 million on caM<br />
therapists despite the percentage of people<br />
using caM remaining constant at 50% in 1993,<br />
52.1% in 2000 and 52.2% in 2004. 3<br />
96 b <strong>Positive</strong> <strong>–</strong> <strong>all</strong> <strong>you</strong> <strong>wanted</strong> <strong>to</strong> <strong>know</strong> <strong>about</strong> hepatitis b: a guide for primary care providers<br />
13<br />
in the past decade, the interest in<br />
complementary medicine and its use in the<br />
treatment of chronic liver disease has also<br />
increased. 1<br />
The role of complementary<br />
medicine in the treatment of<br />
chronic hepatitis B patients<br />
there is evidence <strong>to</strong> suggest that acupuncture,<br />
herbal medicines or the isolated active<br />
ingredients in certain herbal medicines can<br />
play a role in the management of people<br />
with chronic hepatitis b virus (HbV) infection.<br />
these complementary medicines appear <strong>to</strong>