An Overview, Challenges, and Future Directions - SAMSI
An Overview, Challenges, and Future Directions - SAMSI
An Overview, Challenges, and Future Directions - SAMSI
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Experiments Models Connectivity Prediction Summary<br />
Parkinson’s Disease<br />
PD is a chronic, progressive movement disorder affecting at least one<br />
half million patients in the U.S.<br />
No diagnostic test to validate PD determination<br />
Diagnosis: medical history, neurological exam, <strong>and</strong> treatment response<br />
Brain scans <strong>and</strong> lab tests possibly used to rule out other diseases<br />
Symptoms<br />
Tremor, rigidity, bradykinesia (slowness of movement), <strong>and</strong> impaired<br />
balance <strong>and</strong> coordination<br />
With progression, patients may have difficulty walking, talking, or<br />
completing other simple tasks<br />
Non-motor symptoms: cognition, mood, sleep, <strong>and</strong> autonomic function<br />
PD usually affects people over 50 years of age<br />
Drug (e.g. levodopa combined with carbidopa) <strong>and</strong> surgical (DBS)<br />
treatments available, but none halt progression<br />
F. D. Bowman (Emory University) <strong>SAMSI</strong>: NDA RTP, NC 69 / 77
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