An Overview, Challenges, and Future Directions - SAMSI

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Experiments Models Connectivity Prediction Summary Multimodal PD biomarker detection Suggested links between PD and single genetic, imaging, and biologic factors. Many of these are non-specific or insensitive. Single modality biomarkers may not fully address the complexity of PD. We regard PD as a complex, systems-level, multi-dimensional disorder with discrete, but functionally integrated manifestations. We are developing methods to define multimodal PD biomarkers from a massive number of hypothesis driven and exploratory candidate markers. F. D. Bowman (Emory University) SAMSI: NDA RTP, NC 71 / 77
Experiments Models Connectivity Prediction Summary Data Multimodal Parkinson’s Disease Imaging Studies The data will include 81 subjects across three studies 38 Parkinson’s disease patients 32 Healthy control subjects 11 Alzheimers disease patients Potential Biomarkers Imaging (MRI, fMRI, DTI, NM-MRI, CSI) Genetic Neurocognitive Testing Questionnaire-Derived Scores Clinical CSF Neuroinflammation CSF Catecholamine Metabolites F. D. Bowman (Emory University) SAMSI: NDA RTP, NC 72 / 77
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An Overview, Challenges, and Future Directions - SAMSI

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