CURRICULUM VITAE - Mahidol University

CURRICULUM VITAE
Varanuj Chatsudthipong, Ph.D
ADDRESS
EDUCATION
OTHERS
(Office) : Department of Physiology, Faculty of Science, Rama 6 road
Mahidol University, Bangkok 10400, Thailand
Telephone : (662) 201-5614 (office), 6681 274 -3000
Fax : (662) 354-7154 (office)
E-mail : varanuj.cha@mahidol.ac.th
1971-1975 : B.Sc. (Chemistry), Chiengmai University,Thailand
1977-1979 : M.Sc. (Physiology), Mahidol University, Thailand
1983-1987 : Ph.D. (Physiology and Biophysics), University of Illinois at Chicago,
Chicago, IL, USA.
1994-1996 : MBA. Kasetsart University, Thailand
1988-1989 : Exchange Scientist: Department of Pharmacology, Faculty of Medicine,
University of Tokyo, Japan.
1989-1991 : Postdoctoral: Department of Physiology, College of Medicine,
University of Arizona, USA. ( Mentor: Prof. William H. Dantzler)
1997-1999 : Visiting Professor, Department of Physiology, College of Medicine,
University of Arizona, USA.
2005 : Visiting Professor, The Water and Salt Research Center, Aarhus
University, Denmark
PROFESSIONAL POSSITION
- President of Faculty Council, Faculty of Science, Mahidol University
- Professor, Department of Physiology, Faculty of Science, Rama 6 road
Mahidol University, Bangkok 10400, Thailand
AWARDS & GRANTS
2012 : Outstanding research and academic award from Mahidol University
Graduate school alumni award
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2011 : JSSX fellow, Japan
2011-2016 : The higher Education Commission under the National Research
Universities Initiative, Thailand
2010-2013 : Thailand Research Fund, Thailand
2008-2010 : Thailand Research Fund, Thailand
2006 : Research grant from Mahidol University
2005-2010 : Professional researcher’s support fund award, National Science and
Technology Development Agency, Thailand (CO-PI)
2005 : Travel Award from American Physiological Society, USA.
2001 : Travel Award from American Physiological Society, USA.
1997,1999, 2000-10 : Royal Golden Jubilee Grant, Thailand Research Fund, Thailand.
1995 : Research Grant from Mahidol University, Thailand.
1995 : Research Grant from National Research Council, Thailand.
1992-1994 : Research Grant from National Science Foundation, USA.
1988 : Japanese Society Promotion of Science (JSPS) Fellowship
1987 : Research Grant from Mahidol University, Thailand.
1985-1986 : Graduate College Fellowship, University of Illinois at Chicago, USA.
1985 : Phi Kappa Phi Member (National Honor Society), USA.
1985 : Research Grant from Sigma XI, USA.
MEMBERSHIP
- Society of the Physiological Sciences of Thailand
- American Physiological Society, USA.
PROFESSIONAL SERVICE:
REVIEWER
- Editorial Advisory Board: Drug Metabolism and Pharmacokinetics
- Scientific program committee: The 3rd Asia Pacific ISSX Meeting “APISSX 2009”
Bangkok, Thailand
- Scientific program and abstract committee: 4 th Asia Pacific Regional Meeting of
ISSX, 2011, Tainan, Taiwan
- Scientific program committee: The 8 th Federation of Asian and Oceanic
Physiological Societies (FAOPS) congress, 2015, Bangkok, Thailand
- American journal of Physiology – renal
- Applied Biochemistry and Biotechnology
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- Archiv der Pharmazie
- Biochemical Pharmacology
- Biopharmaceutical & Drug Disposition
- Drug Metabolism and Pharmacokinetics
- Engineering in Life Science
- Food additive and contaminants
- Journal of Medicinal food
- Life Sciences
- Method and Findings in Experimental and clinical Pharmacology
- Toxicology Mechanism and Method
- Current Medicinal Chemistry
- Food and Chemical Toxicology
- Journal of Pharmacological Sciences
- Drug Design, Development and Therapy
- Journal of Biomedicine and Biotechnology
MAJOR INVITED SPEAKER
2012 Yale University, School of Medicine, New Haven, USA
2012 Center of Pharmacogenetics, School of Pharmacy, University of
Pittsburgh, USA
2011 The 4 th Asia Pacific ISSX Meeting “APISSX 2011” Tainan, Taiwan
2011 The 3 nd International Conference on Natural Products for Health and
Beauty (Through sustainable health), Thailand
2009 Plenary lecture, Faculty of Pharmacy, Kanazawa University, Japan
2009 Special seminar, Kyorin University School of Medicine, Japan
2009 The 3 rd Asia Pacific ISSX Meeting “APISSX 2009” Bangkok, Thailand
2008 The 2 nd International Conference on Natural Products for Health and
Beauty, Thailand
2008 Proceedings of the International Symposium on New Drug
Development, Chungbuk National University, Korea
2006 The 1 st Asian Pacific ISSX Meeting “APISSX 2006” Jeju, Korea
2005 The Water and Salt Research Center, Aarhus University, Denmark
2003 The 9 th Southeast Asia-Western Pacific Regional Meeting of
Pharmacologists, Busan, Korea.
2001 Yale University School of Medicine, New Haven, USA
2001 National Institute of Environment Health Sciences (NIEHS) North
Carolina, USA.
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SELECTED PUBLICATIONS
1. Sawasvirojwong S, Srimanote P, Chatsudthipong V, Muanprasat C*. An
adult mouse model of Vibrio cholerae-induced diarrhea for studying
pathogenesis and potential therapy of cholera. PLoS Negl Trop Dis. 2013 (In press).
2. Raksaseri P, Chatsudthipong V, Muanprasat C, and Soodvilai S. Liver X receptor
activation modulates CFTR-mediated chloride transport in collecting duct cells. Am J Physiol
Renal Physiol. 2013 (In press).
3. Kittayaruksakul S, Zhao W, Downes M, Evans R, Venkataramanan R, Chatsudthipong V*,
and Xie W. Identification of three novel natural product compounds that activate PXR and
CAR and inhibit inflammation. 2013 (In press).
4. Phatchawan A, Srimaroeng C, Chatsudthipong V, and Lungkaphin A. Decreased Renal
Organic Anion Transporter 3 Expression in Type 1 Diabetic Rats. Am J Med Sciences. 2013
(In press)
5. Muanprasat C, Chatsudthipong V. Cholera: pathophysiology and emerging therapeutic
targets. Future Med Chem. 2013 May; 5(7):781-98.
6. Yuajit C, Homvisasevongsa S, Soodvilai S, Muanprasat C and Chatsudthipong V*. Steviol
reduces MDCK cyst formation and growth by inhibiting CFTR channel activity and
promoting proteasome-mediated CFTR degradation. PLoS One. 2013; 8(3):e58871.
doi:10.1371/journal.pone.0058871.
7. Sungkaworn T, Jiarpinitnun C, Chaiyakunvat P, Chatsudthipong V*. The bivalent display of
Angiotensin II peptides suppresses hyper-responsiveness of AT 1R under oxidative stress
condition. Eur J Med Chem. 2013, 63C: 629-634
8. Muanprasat C, Sirianant L, Sawasvirojwong S, Homvisasevongsa S, Suksamrarn A,
Chatsudthipong V. Activation of AMP-Activated Protein Kinase by a Plant-Derived
Dihydroisosteviol in Human Intestinal Epithelial Cell. Biol Pharm Bull. 2013;36(4):522-8
9. Soodvilai S, Jia Z, Fongsupa S, Chatsudthipong V, Yang T. Liver X receptor agonists
decrease ENaC-mediated sodium transport in collecting duct cells. Am J Physiol Renal
Physiol. 2012; 15;303(12):F1610-6
10. Kittayaruksakul S, Soodvilai S, Asavapanumas N, Muanprasat C, Chatsudthipong V*. Liver
x receptors activation downregulates organic anion transporter 1 (OAT1) in renal proximal
tubule. Am J Physiol Renal Physiol. 2012; 302: F552-F560.
11. Asavapanumas N, Kittayaruksakul S, Meetam P, Muanprasat C, Chatsudthipong V,
Soodvilai S. Fenfibrate down-regulates renal OCT2-mediated organic cation transport via
PPARα-independent pathways. Drug Metab Pharmacokinet. 2012; (5): 513-519.
12. Yousef M, Pichyangkura R, Soodvilai S, Chatsudthipong V, Muanprasat C. Chitosan
oligosaccharide as potential therapy of inflammatory bowel disease: Therapeutic efficacy and
possible mechanisms of action. Pharmacol Res. 2012 ;66(1):66-79
13. Patanayindee J, Muanprasat C, Soodvilai S, Chatsudthipong V*. Antidiarrheal efficacy of a
quinazolin CFTR inhibitor on human intestinal epithelial cell and in mouse model of cholera.
Indian J Pharmacol. 2012 ; 44 (5):619-23
14. Luerang W, Khammee T, Kumpum W, Suksamrarn S, Chatsudthipong V, Muanprasat C.
Hydroxyxanthone as an inhibitor of cAMP-activated apical chloride channel in human
intestinal epithelial cell. Life Sci. 2012 Jun 27; 90(25-26):988-94.
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15. Bunprajun T, Yimlamai T, Soodvilai S, Muanprasat C, Chatsudthipong V*. Stevioside
enhances satellite cell activation by inhibiting of NF-κB signaling pathway in regeneration
muscle after cardiotoxin-induced injury. J Agric Food Chem. 2012; 60(11):2844-51.
16. Muanprasat C, Sirianant L, Soodvilai S, Chokchaisiri R, Suksamrarn A, Chatsudthipong V.
Novel action of the chalcone isoliquiritigenin as a CFTR inhibitor: potential therapy for
cholera and polycystic kidney disease. J. Pharmacol Sci. 2012;118(1):82-91.
17. Sungkaworn T. Lenbury Y, Chatsudthipong V*. Oxidative stress increases angiotensin
receptor type I responsiveness by increasing receptor degree of aggregation using image
correlation spectroscopy. Biochim Biophys Acta. 2011, 1808(10):2496-500.
18. Soodvilai S, Nantavishit J, Muanprasat C, Chatsudthipong V*. Renal organic cation
transporters mediated cadmium-induced nephrotoxicity. Toxicol Lett. 2011; 204(1):38-42.
19. Phakdeekitcharoen B, Kittikanokrat W, Kijkunasathian C, Chatsudthipong V. Aldosterone
increases Na(+) - K(+) - ATPase activity in skeletal muscle of patients with Conn's syndrome.
Clin Endocrinol. 2011; 74:152-9.
20. Wongsamitkul N, Sirianant L, Muanprasat C, Chatsudthipong V*. A plant-derived
hydrolysable tannin inhibits CFTR chloride channel: a potential treatment of diarrhea. Pharm
Res. 2010; 27:490-7.
21. Rattanakul C, Chudoung M, Lenbury Y, Chatsudthipong V, Triampo W, Novaprateep B,
Sungkaworn T. Modeling signal transduction involving G protein coupled receptors by
genetic algorithm and nonlinear spatiotemporal analysis. Recent Advances in Applied
Mathematics and computational and Information Science. 2010; 1:39-44.
22. Meetam P, Srimaroeng C, Soodvilai S, Chatsudthipong V*. Role of estrogen in renal
handling of organic cation, tetraethylammonium: in vivo and in vitro studies. Biol Pharm
Bull. 2009; 32:1968-72.
23. Rattanakul C, Sungkaworn T, Lenbury Y, Chudoung M, Chatsudthipong V, Triampo W,
Novaprateep B. Nonlinear spatiotemporal analysis and modeling of signal transduction
pathways involving G protein coupled receptors. International Journal of Mathematical
Models and Methods in Applied Sciences. 2009; 3(3):219-229.
24. Rattanakul C, Lenbury Y, Wollkind DJ, Chatsudthipong V. Weakly nonlinear analysis of a
model of signal transduction pathway involving membrane based recptors. Nonlinear
Analysis, Theory, Methods and Applications. 2009; 71 : e1620-5.
25. Meetam P, Srimaroeng C, Soodvilai S, Chatsudthipong V*. Regulatory role of testosterone
in organic cation transport: in vivo and in vitro studies. Biol Pharm Bull. 2009; 32(6):982-7.
26. Chatsudthipong V*, Muanprasat C. Stevioside and related compounds: therapeutic benefits
beyond sweetness. Pharmacol Ther. 2009; 121(1):41-54.
27. Pariwat P, Homvisasevongsa S, Muanprasat C, Chatsudthipong V*. A natural plant-derived
dihydroisosteviol prevents cholera toxin-induced intestinal fluid secretion. J Pharmacol Exp
Ther. 2008; 324(2):798-805.
28. Yangthara B, Mills A, Chatsudthipong V, Tradtrantip L, Verkman AS. Small-molecule
vasopressin-2 receptor antagonist identified by a g-protein coupled receptor "pathway"
screen. Mol Pharmacol. 2007; 72(1):86-94.
29. Srisawang P, Chatsudthipong A, Chatsudthipong V*. Modulation of succinate transport in
Hep G2 cell line by PKC. Biochim Biophys Acta. 2007; 1768(6):1378-88.
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30. Soodvilai S, Chatsudthipong A, Chatsudthipong V*. Role of MAPK and PKA in regulation
of rbOCT2-mediated renal organic cation transport. Am J Physiol Renal Physiol. 2007;
293(1): F21-7.
31. Muanprasat C, Kaewmokul S, Chatsudthipong V*. Identification of new small molecule
inhibitors of cystic fibrosis transmembrane conductance regulator protein: in vitro and in vivo
studies. Biol Pharm Bull. 2007; 30(3):502-7.
32. Rattanakul C, Lenbury Y, Bell J, Chatsudthipong V, Triampo W, Crooke PS. Spatial
Turing-type Pattern Formation in a Model of Signal Transduction Involving Membrane-based
Receptors Coupled by G Proteins. Cancer Inform. 2006;2:329-43.
33. Lungkaphin A, Lewchalermwongse B, Chatsudthipong V*. Relative contribution of OAT1
and OAT3 transport activities in isolated perfused rabbit renal proximal tubules. Biochim
Biophys Acta. 2006; 1758(6):789-95.
34. Srimaroeng C, Jutabha P, Pritchard JB, Endou H, Chatsudthipong V*. Interactions of
stevioside and steviol with renal organic anion transporters in S2 cells and mouse renal
cortical slices. Pharm Res. 2005; 22(6):858-66.
35. Srimaroeng C, Chatsudthipong V, Aslamkhan AG, Pritchard JB. Transport of the natural
sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1;
SLC22A6) and hOAT3 (SLC22A8). J Pharmacol Exp Ther. 2005; 313(2):621-8.
36. Soodvilai S, Wright SH, Dantzler WH, Chatsudthipong V*. Involvement of tyrosine kinase
and PI3K in the regulation of OAT3-mediated estrone sulfate transport in isolated rabbit renal
proximal tubules. Am J Physiol Renal Physiol. 2005; 289(5):F1057-64.
37. Zhang X, Groves CE, Bahn A, Barendt WM, Prado MD, Rodiger M, Chatsudthipong V,
Burckhardt G, Wright SHl. Relative contribution of OAT and OCT transporters to organic
electrolyte transport in rabbit proximal tubule. Am J Physiol Renal Physiol. 2004;
287(5):F999-1010.
38. Soodvilai S, Chatsudthipong V, Evans KK, Wright SH, Dantzler WH. Acute regulation of
OAT3-mediated estrone sulfate transport in isolated rabbit renal proximal tubules. Am J
Physiol Renal Physiol. 2004; 287(5):F1021-9.
39. Lungkaphin A, Chatsudthipong V, Evans KK, Groves CE, Wright SH, Dantzler WH.
Interaction of the metal chelator DMPS with OAT1 and OAT3 in intact isolated rabbit renal
proximal tubules. Am J Physiol Renal Physiol. 2004; 286(1):F68-76.
40. Kaewmokul S, Chatsudthipong V, Evans KK, Dantzler WH, Wright SH. Functional
mapping of rbOCT1 and rbOCT2 activity in the S2 segment of rabbit proximal tubule. Am J
Physiol Renal Physiol. 2003; 285(6):F1149-59.
41. Jutabha P, Kanai Y, Hosoyamada M, Chairoungdua A, Kim DK, Iribe Y, Babu E, Kim JY,
Anzai N, Chatsudthipong V, Endou H. Identification of a novel voltage-driven organic anion
transporter present at apical membrane of renal proximal tubule. J Biol Chem. 2003;
278(30):27930-8.
42. Chatsudthipong V*, Jutabha P. Effect of steviol on para-aminohippurate transport by
isolated perfused rabbit renal proximal tubule. J Pharmacol Exp Ther. 2001; 298(3):1120-7.
43. Jutabha P, Toskulkao C, Chatsudthipong V*. Effect of stevioside on PAH transport by
isolated perfused rabbit renal proximal tubule. Can J Physiol Pharmacol. 2000; 78(9):737-44.
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44. Chatsudthipong V, Jutabha P, Evans KK, Dantzler WH. Effects of inhibitors and substitutes
for chloride in lumen on p-aminohippurate transport by isolated perfused rabbit renal
proximal tubules. J Pharmacol Exp Ther. 1999;288(3):993-1001.
45. Chatsudthipong V, Dantzler WH. PAH/alpha-KG countertransport stimulates PAH uptake
and net secretion in isolated rabbit renal tubules. Am J Physiol. 1992;263(3 Pt 2):F384-91.
46. Chatsudthipong V, Dantzler WH. PAH-alpha-KG countertransport stimulates PAH uptake
and net secretion in isolated snake renal tubules.Am J Physiol. 1991;261(5 Pt 2):F858-67.
47. Dantzler WH, Wright SH, Chatsudthipong V, Brokl OH. Basolateral tetraethylammonium
transport in intact tubules: specificity and trans-stimulation. Am J Physiol. 1991;261(3 Pt
2):F386-92.
48. Chatsudthipong V, Chan YL. Inhibitory effect of angiotensin II on renal tubular transport.
Am J Physiol. 1991 ;260 (3 Pt 2):F340-6.
49. Chatsudthipong V*, Sophasan S, Jariyawat S. The possible involvement of calcium in renal
proximal tubular reabsorptive defect in the rat after release of ureteral obstruction. Can J
Physiol Pharmacol. 1990 ; 68(6):667-70.
50. Chan YL, Chatsudthipong V, Wang T. Angiotensin receptor mediated regulation of
transport in the rat proximal tubule. Prog Clin Biol Res. 1988;258:149-60.
51. Sophasan S, Chatsudthipong V, Kraisawekwisai S. Kidney pressures after the release of 24
hours of bilateral ureteral ligation in the rat. J Urol. 1982;128(5):1081-6.
52. Sophasan S, Sanposn W, Kraisawekwisai S, Chatsudthipong V. The effects of dopamine on
kidney function of rats. Arch Int Pharmacodyn Ther. 1981; 252(2):219-28.
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