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What is the role of the ExtraCellular Matrix in the<br />
formation of lines, furrows and wrinkles?<br />
DÉRÈGLEMENT DES ADIPOCYTES ET DES FIBROBLASTES :<br />
UNE ORIGINE GÉNÉTIQUE<br />
The Extracellular Matrix (ECM) is the largest<br />
component of normal skin and gives the skin<br />
<strong>it</strong>s unique properties of elastic<strong>it</strong>y, tensile<br />
strength and compressibil<strong>it</strong>y.<br />
These properties are due to the combination<br />
of two main classes of molecules, which are<br />
secreted by fibroblasts and epidermal cells:<br />
• structural proteins: collagens, elastin<br />
• proteoglycans: like hyaluronic acid, which<br />
are large and highly hydrated.<br />
These molecules are assembled and<br />
organized in a specific way into the<br />
Extracellular Matrix in order to ensure the<br />
structural integr<strong>it</strong>y of the skin
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