ANGELICA EXTRACT BG - Cosmesi.it

ANGELICA EXTRACT BG
- Maruzen Leaf Extract Series -

Introduction
Leaf and Human Skin
“Leaf tissue and human skin may
share some common characteristics”,
“Why do leaves look healthy even
though they are exposed to sunlight
everyday?”…Based on these
perspectives, Maruzen
Pharmaceuticals developed a series of
leave extracts especially for skin.
Epidermal
cell
Mesophyll
organization
Epidermal
cell
Sectional view of the leaf
Ultraviolet rays
Intracellular
Generation of active oxygens 1 O 2
, O 2-
Scavenge active oxygens
Leaf: polyphenol, carotenoid, etc.
Skin: SOD, catalase, etc.
Keratinocyte
Epidermis
Damage of the cell
Dermis
Sectional view of the skin
Aging
Leaf: Malfunction of the photosynthesis
Skin: Formation of wrinkles and inflammation
Angelica Leaf
The angelica keiskei grows in southern subtropical islands in Japan. The
dried leaves of this plant are used as a health-giving tea and the fresh
leaves are added to miso soup. It is said that the leaves function as a
tonic, prolong life, cure hypertension and aid recovery from fatigue.
ANGELICA EXTRACT BG is a recommended material aimed at antiaging
cosmetics as it promotes hyalulonic acid and collagen synthesis
and strengthens “Tight Junction”, a new key word in skin barrier
function.
Tomorrow Leaf ~ Ashita-ba ~
Angelica keiskei leaf is called Ashitaba (), meaning tomorrow
leaf in Japan due to its ability to reproduce its green leaves almost in
one day after they are picked. From this naming, ANGELICA EXTRACT
BG can give the consumer a re-vitalised image matching the goal of
anti-aging cosmetics.

Barrier Function
Tight Junction (TJ) ~ A New Finding in Barrier Function ~
Skin Barrier Function
Skin barrier function plays these important roles :
A : Controls the penetration of water
B : Prevents the penetration of foreign matter (bacteria, virus)
It had been thought that only the stratum corneum was involved in barrier function.
In recent years, it was discovered that stratum granulosum also plays a role with barrier function.
The key word is Tight Junction.
Stratum corneum
Stratum granulosum
Stratum spinosum
Stratum basal
TJ
Extracelluar
Intracelluar
TJ
Composition of TJ
Occludin, Claudin-1, Claudin-4
What is TJ?
- A kind of protein which is composed of Occludin, Caudin-1, Caudin-4
- Surrounds the cells in the shape of a belt
- Exists in the stratum granulosum
What are the functions of TJ?
“ An intercellular adhesion device”
Increasing cell-cell adhesion
Controlling the penetration of substances between cells
Preventing over water evaporation and against foreign matter (bacteria, virus) penetration
Good function
Malfunction
H2O
UV
H2O
Keeping skin moisture
TJ
UV
damage
Loss of skin moisture
Promotion of Claudin-1 Production
Promotion of
claudin-1 production (%)
103.2 1.6*
Control 2.5 +
(g/mL)
Angelica extract (solid)
*: p

Anti-Aging Effect
Skin Aging Is Caused by Physiological and Photo Aging
Physiological Aging Affects…
Reduced Fibroblast Proliferation
Reduced Extracellular Matrix (Decomposition of Collagen)
Photo Aging Affects…
Generation of Active Oxygen
Reduced Fibroblast Proliferation
Reduced Extracellular Matrix (Decomposition of Collagen)
The Result
Wrinkles, Sagging, Dullness, Roughness, Dryness…
Oxidation
Poor fibroblast proliferation
Collagenase (MMP-1) activation
Collagen decomposition
Wrinkles, Sagging, Dullness
Promotion of Collagen Synthesis
Promotion of Hyaluronic Acid Synthesis
Collagen synthesis (%)
182.1
443.6*
Hyaluronic acid synthesis (%)
350.6*
Control 25 100 +
(g/mL)
Control 50 +
(g/mL)
Angelica extract (solid)
*: p