George A. Digenis, Ph.D. - University of Kentucky - College of ...

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Curriculum Vitae
George A. Digenis, Ph.D.
Table of Contents
Section
Page
I. General Information 1
II. Education 1
III. Professional Experiences 1
IV. Academic Appointments 1
V. Hospital or Clinical Appointments 2
VI. Consulting Activity 2
VII. Teaching Activity 2
VIII. Advising 2
IX. Administrative Actvity and University Service 4
X. Special Assignments 4
XI. Specialty Board 4
XII. Honors 4
XIII. Professional Activity and Public Service 5
XIV. Speaking Engagements 5-17
XV. Research Publications 17-30
Books and Chapters 30
Patents 31
Poster Presentations 32-43
Funded Grants 44
PhD. Students graduated 52

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GEORGE A. DIGENIS, Ph.D.
I. GENERAL INFORMATION
Home Address: 3908 Zaring Mill Court, Louisville, KY 40241
Phone: 502-412-3413; Fax 502-412-4467
Office Address:
511C Pharmacy Building
College of Pharmacy, University of Kentucky
Lexington, KY 40536-0082
Phone: 859- 257-1970; FAX: 859-257-7585
e-mail: digenis@pop.uky.edu
Birthdate: September 28, 1935
Marital Status: Married
Spouse Name Helen
Children:
Alexander, Emily, Melina
Citizenship: United States of America by Naturalization
II.
EDUCATION
1954 - Greek Gymnasium - Greece
1959 - B.S., Pharmacy, American University of Beirut, Beirut, Lebanon
1962 - M.S., Pharmacy, University of Wisconsin, Madison, Wisconsin
1964 - Ph.D. Organic Pharmaceutical Chemistry, University of Wisconsin, Madison,
Wisconsin (Dr. H. Whitlock).
Thesis title: "Studies on Certain Amines of Biological Interest and Synthesis of
Dibenzo [b,f] Azepin and Attempted Synthesis of N-Substituted Dibenzo [b,f] Azepin"
1997 - Ph.D., (Honorary) Pharmacy and Pharmaceutical Technology, University of Athens,
Athens, Greece
III.
IV.
PROFESSIONAL EXPERIENCES
ACADEMIC APPOINTMENTS
2002-Present
Emeritus Professor
1974-2001 Professor of Medicinal Chemistry and Pharmaceutics
College of Pharmacy, University of Kentucky.
Professor, Department of Nuclear Medicine, College of Medicine
University of Kentucky.
Professor of Toxicology, University of Kentucky.
Prior:
1975-80 Associate Scientist, Sloan-Kettering Institute for Cancer Research
1975 Associate Professor of Nuclear Medicine, College of Pharmacy,
University of Kentucky
1970-74 Associate Professor of Materia Medica and Pharmaceutical Chemistry,
College of Pharmacy, University of Kentucky
Professor of Medicinal, Chemistry and Pharmacognosy,
College of Pharmacy, University of Kentucky

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1967-70 Assistant Professor of Materia Medica and Pharmaceutical
Chemistry,
College of Pharmacy, University of Kentucky
1964-67 Assistant Professor of Pharmaceutical Chemistry,
American University of Beirut
V. HOSPITAL OR CLINICAL APPOINTMENTS
N/A
VI.
CONSULTING ACTIVITY
Consultant, Johnson and Johnson Laboratories
Consultant, Eli Lilly and Company
Consultant, Hoffmann-LaRoche, Inc., 1976-present
Consultant, GAF Corporation, Wayne, NJ
Consultant, Interx Research Corp. Lawrence, Kansas
Consultant, Ortho Pharmaceutical Corporation
Consultant, Purdue Frederick Co.
Consultant, Lederle Laboratories
Consultant, Farmitalia Carlo Erba, Milan, Italy
Consultant, Vectorpharma, Trieste, Italy
Consultant, Capsugel, Warner-Lambert, New Jersey
Consultant, Lane Pharmaceuticals, Inc., Paris, Kentucky
Consultant, Schering Plough Corporation, Kenilworth, NJ
Consultant, Protein Delivery, Inc.
Consultant, Abbott Labs
VII.
TEACHING ACTIVITY
American University of Beirut
- Physical Pharmacy, 3 credit hours, major responsibility for the course
- Medicinal Chemistry, 2 semesters, 3 credit hours each, major responsibility for the course
- Advance Natural Products Chemistry, 3 credit hours, major responsibility for the course
College of Pharmacy, University of Kentucky
- PHR 620 Chemistry of Natural Products, 3 credit hours, major responsibility for the course
- PHR-622 Advanced Pharmaceutics - Nuclear Medicine
- PHR 762 Bio-organic Mechanisms, 3 credit hours, major responsibility for the course
- PHR 778 Seminar in Pharmaceutical Sciences, 1 credit, major responsibility for the course
- PHR 862 Contributes to Pharmacotherapeutics, 7 credits, secondary responsibility for the
course
- PHR-924 Basic Principles of Pharmaceutical Science: Drug Form Design, 3 credit hours,
major responsibility for course
VIII.
ADVISING ACTIVITY
Ph.D. - Chairman
V. Mihranian, 1969-73 Mary Faye Smith, 1978-82
S. Shakashir, 1970-75 George Garbolas, 1980-86
M. Theodorakis, 1970-76 Munir Nassar, 1980-84
C. Kook, 1972-76 Grey Snyder, 1981-82
J. Triplett, 1972-77 Prince Hinson, 1979-82
G. Martin. 1972-76 Ralph Bouvette, 1982-86
R. Beihn, 1975-79 Karl Niehaus, 1981-82

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S. Hadjioannou, 1975-78 Abdul Kareem, 1983-86
R. McQuinn, 1975-78 William Rencher, 1982-88
D. Casey, 1976-78 Helen Yip, 1984-88
Y. Cheng, 1976-79 Sandra Savidge, 1987-91
M. Jay, 1976-79 Eric Dadey,
Alan Parr 1982-1986
Walter Doll
David Wells, 1982-1986
Fatemeh Mohammadi
Brian Walter, 1984-88
John R. Finch
William Banks, 1985-90
Nikolaos P. Rodis
Todd Elder, 1986-91
Nabil B. Darwazeh
Zanyl Li Erik Sandefer, 1996
R. Yancy, 1977-78 Hanan S. Anwar, 1997
Suzanne Byrd, 1979-80 Richard D. Page, 1997
Mike Fakes, 1979-83 Thomas B. Gold, 1998
Munir Hussain, 1978-83 Jaber V. Qasem, 1999
Judy McClanahan, 1979-84
Member
J. Ong Sheryl Szeinback Lingkuen Huang
S. Stavchansky David Small Yadong Zhu
D. Sanvordekar Terrence Tita Vijayalakshmi Sethuraman
J. Truelove Tyrone Felder Denise Hannibal
J. Newburger Lee-Young Chau Jeffrey A. Hughes
R. Gural Ken Cundy Robert K. Mansfield
Don Chambers Rong-Fong Chem Susan L. Way
Ginger Gautam Clifford Tubsoi Russell Mumper
Karen Oseekey Akram Saab Aimee K. Bence
John Ostrander Pete Glavinos Agaths Feltus
Kenneth Brouwer Ganesan Vaidyanathan Omar A. Ghoshen
Rima Bawarshi Wai-ming Kan Janusz W. Kostanski
Alan Mark Kook (Chem) Xiao-jiu June Zhu Joshua T. Ayers
Riad Awad Trupti Deshmukh Thomas Williams
Steve Godin
Ahraf Troboulsi
Donald Mark Chambers Danny Kao
Chang-jin Wang
Supinan NaPhuket
Samera Hassan
Jouthi Matheru
Thomas Hodgkins
Bassam Tashtoush
Dennis Mann
Juan Correa
Susan Milosovich
Sisay Gebrekidan
Pharm.D - Chairman
V. Payne, 1973-76
Post-Doctoral Fellows/Research Associates
M. Miyamoto, 1968-70 B. Agha, 1981-87H. Yamakita, 1989-90
K. Yan, 1969-71 R. Goto, 1980-81 T. Suzuki, 1990-1991
M. Shambhu, 1970-80 K. Kobayashi, 1981-82 T. Tabata, 1991-1992
M. Williams, 1974-77 M. Shinogi, 1982-83 U. Calis, 1991-
V. Papageorgiou, 1976-77 K. Tsuji, 1982-83 K. Takeda, 1993-1995
C. Issidorides, 1977-78 M. Kato, 1984-854 Y. Tanizawa, 1996-1997
J. Chaney, 1979-84 K. Saito 1984-85 K. Matsumoto, 1997-1998
A. Hawi 1984-88 D. Noskova 1989-95

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IX.
ADMINISTRATIVE ACTIVITY AND UNIVERSITY SERVICE
University - University Senate 1972-73
- Tobacco and Health Technical Advisory 1973-76
- Academic Area Advisory Committee (Chairman) 1979-81
- Graduate Faculty in Toxicology 1980 – present
- Major Research Equipment 1980-81
- Radioactive Drug Committee 1991-94
Medical Center - Medical Center Radioisotopes 1968-75
- Cancer Committee 1973-76
- Planning Committee for Institutional Cancer Grant 1974-75
- Radiation Health, Safety and Medical Center Radioisotope Committee
1981
- Task Force on Research 1981
- MRISC Committee, 1987-88
College - Library 1968-69
- Graduate Program 1968-present
- Research and Seminar, (Chairman) 1968-74
- Curriculum 1971-74, 1981-82
- Administrative Council 1972-present
- Building, Space and Services 1972-73
- Ad Hoc Committee for Student Input into Faculty Evaluations 1973-74
- Discussion Group for Achievement of Improved Professional
Interaction 1973-74|
- Nomination (Chairman, 1973-75), 1975-76, 1981-present
- Discussion Group for Bringing Distinguished Educators to the College
and for Giving Visibility Abroad to College Programs and People
Chairman)1973-74
- Appointment, Promotion and Tenure,1981-86.
- Graduate Studies Committee, 1987-88
- CPST Search Committee, 1988
- Admissions Committee, 1989
- Continuing Education Committee, 1989-90
- History of Drugs and Pharmacy, 1989-90
- Appointment, Promotion and Tenure, 1990-1993
- Seminar Committee, Chairman, 1991-1992
X. SPECIAL ASSIGNMENTS
XI.
XII.
SPECIALTY BOARD
HONORS
The University of Wisconsin Rennebohm Award (1960) for best teaching assistant in
pharmacy
The Lundsford-Richardson Pharmacy Award (1964) - for graduate research
The William B. Sturgill Award for outstanding contribution to graduate education by member
of graduate faculty, May, 1984
Distinguished Lecturer, College of Pharmacy, April 21, 1988
Fellow of the American Association of Pharmaceutical Scientists 1990

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XIII. PROFESSIONAL ACTIVITY AND PUBLIC SERVICE
American Association of Pharmaceutical Scientists
American Pharmaceutical Association
American Chemical Society
American Association of Colleges of Pharmacy
Rho Chi
Sigma Xi
XIV.
SPEAKING ENGAGEMENTS
Presentations
"Some Recent Advances in Indolealkyl Chemistry," Rho Chi Lecturer, Mercer University,
Southern School of Pharmacy, Atlanta, Georgia, 1969.
"Some Recent Advances in Indolealkyl Chemistry," Scott's Seed Company, Marysville, OH,
1969.
"A review on the Molecular Pharmacology of Some Antipsychotic Drugs," Smith, Kline and
French Laboratories, 1970.
"Lipid Chemistry and Biochemistry in Echinococcus Granulosus," Smith, Kline and French
Laboratories, 1971.
"Preparations and Reactions of Polymeric Anhydrides," Seventh Annual Higuchi Research
Seminar, Lake Ozark, Missouri, 1974.
"Short-Lived Radiopharmaceuticals," 17th National Meeting of the American Pharmaceutical
Association Academy of Pharmaceutical Sciences, New Orleans, Louisana, 1974.
"The Preparation of Insoluble Resins and Their Applications in Chemistry and Pharmacy,"
Purdue University, West Lafayette, Indiana, 1974.
"Chemistry, Stereochemistry and Anti-psychotic Activity of Some Acridan Drugs," University
of kentucky, Department of Pharmacology, College of Medicine, 1975.
"The Preparation of Insoluble Resins and Their Applications in Chemistry and Pharmacy,"
University of Kentucky, Deptartment of Chemistry, 1975.
Invited Presentations
"Potential Uses of Short-Lived Radioisotopes in Pharmaceutics," 8th Annual Midwinter
Higuchi Pharmaceutical Research Seminar, Lake Ozark, Missouri, 1975.
"Radiopharmacy", American Association of Colleges of Pharmacy, Washington, DC, 1975.
"A Medicinal Chemist's Approach to Radiopharmaceuticals," Sloan-Kettering Research
Institute, New York, NY, 1976.
"Recent Advances in the Use of External Scintigraphy and its Potential in the Assessment of
Drug Efficacy," Hoffman-La Roche Co., Nutley, NJ, 1976.
"Novel Approaches to Selective Filters," Phillip Morris Laboratories, Richmond, VA, 1976.
"A Method for Monitoring Capsule Dissolution in Man Using External Scintigraphy," 9th
Annual Midwinter Higuchi Research Seminar, Lake Ozark, MO, 1976.
"Stable and Short-Lived Isotopes in the Study of Tissue Distribution," Animal Health Institute
Symposium, Arlington, VA, 1976.

"Use of Technetium and Other Radioactive Complexes in Nuclear Medicine," University of
Kentucky, Department of Chemistry, 1976.
" 13 C-NMR in the Elucidation of Reaction Mechanism" 10th Annual Midwinter Higuchi
Research Seminar, Lake Ozark, MO, 1977.
"Some Clinical Applications of Short-Lived Radiopharmaceuticals," University of Texas, San
Antonio, TX, 1977.
"A Medicinal Chemist's Approach to Radiopharmaceuticals," University of Texas at Austin,
TX, 1977.
"The Use of External Scintigraphy in the Determination of Capsule and Tablet Disintegration
Times," Smith, Kline and French Laboratories, Philadelphia, PA, 1977.
"External Scintigraphy and Its Utilization in Monitoring Tablet Disintegration in Humans,"
Ayerst Laboratories, Rouse Point, New York, 1977.
"External Scintigraphy and its Application to In Vivo Tissue Distribution Studies and
Assessment of Drug Efficacy," Ortho Pharmaceutical Corp., Raritan, NJ, 1978.
"In Vivo Studies of Drug Release," Land O'Lake Conference, 1978, "Radiopharmaceuticals,"
Amman, Jordan, 1978.
"Studies on the In Vivo Disposition of 13 N-Labeled Nitrosoureas," Eleventh Annual Higuchi
Research Seminar, Lake Ozark, Missouri, 1978.
"In Vivo Disposition of 13 N-Labelled Nitrosoureas and Nitrosocarbmates," Regional Cancer
Research Conference, Lexington, Kentucky, 1978.
"Gave series of lectures on Radiopharmaceuticals and Medicinal Chemistry at the University
of Cairo, Egypt, 1975.
"In Vivo Studies of Drug Release: The Utilization of External Scintigraphy and Perturbed
Angular Correlation in the Assessment of Dosage Form Performance In Vivo," 20th Annual
National Industrial Pharmaceutical Research Conference, Lake Delton, Wisconsin, 1978.
Preparation of 13 N -Labeled Streptozotocin and Nitrosocarbaryl," Second International
Symposium on Radiopharmaceutical Chemistry, Oxford, England, 1978.
"The Emerging Role of Radiopharmaceuticals in Diagnosis, Drug Research and Assessment of
Dosage Form Performance In Vivo," The Jordan Pharmaceutical Association, Amman,
Jordan, 1978.
"In Vivo Disposition of 13 N-Labeled Nitrosocarbamates," 12th Annual Midwinter Higuchi
Research Seminar, Lake Ozark, Missouri, 1979.
"The Potential of Short Lived Radionuclides in the Analysis of Drugs in Biological Fluids,"
American Society for Pharmacology and Experimental Therapeutics, Portland, Oregon, 1979.
"Synthesis and In Vivo Disposition of 13 N - Labeled Nitrosoureas and Nitroso-carbamates,"
114th National Meeting of the American Chemical Society, Washington, DC, 1979.
"The Absorption and Distribution of Vaginally Administered Povidone-Iodine-131 in Barren
and Pregnant Rats," Colloquim in Connection with the 11th International Congress
ofChemotherapy, Boston, MA, 1979.
"Toxicology Studies: The Utilization of Short-Lived Radionuclides in the Assessmentof the
Safety and Disposition of NovelProducts,"Program for Applied Research on Fertility
Regulation in Mexico City, 1980.
"The Utilization of Short-Lived Radionuclides in Tissue Distribution Studies," University of
Illinois at Urbana-Champaign, 1980.
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"Synthesis and Brain Uptake of Carbon-11 Phenethylamine," 28th Annual Meeting of the
American Pharmaceutical Association Academy of Pharmaceutical Sciences in Washington,
DC, 1980.
13th Annual Midwinter Higuchi Research Seminar, 1980.
"Synthesis and Brain Uptake of Carbon-11 Phenethylamine," Third International Symposium
on Radiopharmaceutical Chemistry at Washington University, St. Louis, MO, 1980.
"In Vivo Drug Product Disintegration and Dissolution as Measured by Non-Invasive
Methods," Nassau, Bahamas, 1980.
"A Possible Mechanism of Bactericidal Action of the Povidone-Iodine Complex," National
Meeting of the American Society of Microbiology, Dallas, Texas, 1981.
"A Rapid Resolution Procedure for the Preparation of 11 C-labeled D-amino acids," 14th
Annual Midwinter Higuchi Research Seminar, Lake Ozark, MI, 1981.
"Examples of the Utilization of Short-lived Radionuclides in the Assessment of Formulation
and In Vivo Disposition of Drugs," 2nd Symposium-Applications of Radionuclides in Drug
Formulation Studies, Nottingham, England, 1981.
"Recent Advances on the Mechanism of Action of PVP-I 2 Complex," and "New Horizons in
Povidone Research," GAF Corporation, Wayne, New Jersey, 1981.
"Influence of Amphetamine on the Brain Efflux of 11 C-labeled Phenethylamine," 15th Annual
Midwinter Higuchi Research Seminar, Lake Ozark, MI, March 14-17, 1982.
Gastric Emptying as a Clinical Tool," American Hellenic Medical Association, Crete, Greece,
July 18, 1982.
"Application of Short-Lived Radionuclides to Formulation Development," Mid-West
Pharmaceutical Group Fall Meeting, Chicago, IL, October 25, 1982.
"Studies on the Toxicology of Polymers and their Monomers," First Kuwait Conference of
Pharmaceutical Sciences, Safat - Kuwait, November 2-4, 1982.
"Disposition of N-vinyl-pyrrolidone in the Rat," BASF Laboratories, Ludwigshafen, West
Germany, November 9-10, 1982.
"Effect of Smoking on Elastolytic Activity of Rat Serum and Lung Homogenates," Academy of
Pharmaceutical Sciences 33rd National Meeting, San Diego, CA, November 14-18, 1982, p.
151.
"Effect of α-Difluoromethylornithine on Tissue Distribution of 14 C-Putrescine in Tumor
Bearing Mice," Academy of Pharmaceutical Sciences 33rd National Meeting, San Diego, CA.,
November 14-18, 1982, p. 150.
"Carbonate and Carbamate Esters as Potential Substrates for the Determi- nation of Total
Lung Proteolysis," Academy of Pharmaceutical Sciences 33rd National Meeting, San Diego,
CA, November 14-18, 1982, p. 149.
"Perturbed Angular Correlation Measurements for Assessment of Dosage Forms and Drug
Delivery," Academy of Pharmaceutical Sciences 33rd National Meeting, San Diego, CA,
November 14-18, 1982, p. 105.
"Perturbed Angular Correlation for the Study of Suppository Behavior In Vivo," Academy of
Pharmaceutical Sciences 33rd National Meeting, San Diego, CA, November 14-18, 1982, p.
106.
"Radionuclidic Method for the Determination of Critical Micellar Concentration of Ionic
Surfactants in Water," Academy of Pharmaceutical Sciences 33rd National Meeting, San
Diego, CA, November 14-18, 1982, p. 156.
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"Studies on the Interaction of PVP-Related Lactams with Aromatic Compounds Using NMR
Spectroscopy," International Symposium on Povidone, Lexington, Kentucky, April 17-20,
1983.
"Disposition of N-vinylpyrrolidinone in the Rat," International Symposium on Povidone,
Lexington, Kentucky, April 17-20, 1983.
"Studies on the Association of 14 C-Povidone- 131 I-Iodine Complex with Bacterial Cell Wall,"
International Symposium on Povidone, Lexington, Kentucky, April 17-20, 1983.
"Studies in Molecular Pharmacology with External Scintigraphy," University of Louisville,
Department of Pharmacology and Toxicology, April 27, 1983. Invited speaker.
"Long-Acting Contraceptive Delivery Systems," at the International Workshop on Long-Acting
Contraceptive Delivery Systems sponsored by the Program for Applied Research on Fertility
Regulation, Northwestern University, New Orleans, LA, May 31-June 4, 1983. Invited
speaker.
"Perturbed Angular Correlation for the Study of Surfactant Behavior in Aqueous Solutions,"
57th Colloid and Surface Science Symposium, Toronto, Ontario, Canada, June 12-16, 1983.
"Noninvasive Drug Dissolution Measurement in Human Volunteers," 56th Colloid and
Surface Science Symposium, Toronto, Ontario, Canada, June 12-16, 1983.
"Design of Active Site Directed Inhibitors of Lung Proteases," at the Department of Pharmacy,
Univerza Edvarda Kardelja V. Ljublijani, Yugoslavia, September, 16, 1983.
"Tissue Distribution Studies Using External Scintigraphy and Short-lived Radionuclides,"
Department of Pharmacy, Univerza Edvarda Kardelja V. Ljubljani, Yugoslavia, September 16,
1983.
"Carbamate Esters as Active Site Directed Inhibitors of Elastase" APhA Academy of
Pharmaceutical Sciences 35th National Meeting, November 13-17, 1983, p. 175.
"Carbamate Esters as Inhibitors of Serine Proteases," APhA Academy of Pharmacetuical
Sciences 35th National Meeting, November 13-17, 1983, p. 175.
"A Study on the Disposition of Vaginally Administered 131 I-Radioiodinated Nonoxynol-9 in
Barren Rats and Baboons" NIH Fertility and Maternal Health Drugs Advisory Committee,
Food and Drug Administration, Bethesda, Maryland, December 15, 1983.
"Novel Specific Inhibitors of Lung Proteases," Seventeenth Annual Higuchi Research Seminar,
Lake Ozark, Missouri, March 14, 1984.
"Development of Agents for Early Detection of and Susceptibility to Emphysema in Smokers,"
Tobacco and Health Research Institute, Site Visit, Lexington, Kentucky, April 23, 1984.
"A Study on the Disposition of Vaginally Administered [ 131 I]-Radio- iodinated Nonoxynol-9 in
Barren Rats," 131st APhA Annual Meeting, Montreal, Canada, May 8, 1984.
"Short Course on Non-Invasive Techniques in the In Vivo Assessment of Solid Dosage Forms
and Tissue Distribution of Drugs," Abbott Laboratories, Chicago, Illinois, May 22, 1984.
"Review and Evalution of the Graduate and Research Programs," University of Pittsburg
School of Pharmacy, Pittsburg, Pennsylvania, June 13, 1984.
"Role of Medicinal Chemistry in the Design of Novel Drug Substances," University of
Ljubljani, Ljubljana, Yugoslavia, July, 1984.
"Design, Synthesis and Evaluation of Enzyme Inhibitors (elastase, acrosin)", University of
Ljubljani, Ljubljana, Yugoslavia, July, 1984.
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"Solid Phase Reactions in Medicinal Chemistry," University of Ljubljani, Ljubljana,
Yugoslavia, July, 1984.
"Drug Metabolism and New Radiomonitored HPLC Techniques," University of Ljubljani,
Ljubljana, Yugoslavia, July, 1984.
"In Vivo Assessment of Oral Dosage Forms by External Scintigraphy", Schering Plough
Corporation, Kenilworth, New Jersey, October 8, 1984.
"GI Transit Times of Two Radiolabeled Placebo Formulations", Berlex Laboratories, Cedar
Knolls, New Jersey, October 9, 1984.
"Examples of Utilization of Short-lived Radionuclides in the Assessment of Drug
Formulations In Vivo" and "Studies on the In Vivo Disposition of drugs by External
Scintigraphy", Searle Pharmaceuticals, Chicago, Illinois, October 24, 1984.
"Studies on the Interaction of N-Methyl-2-Pyrrolidone with Aromatic Compounds Using NMR
Spectroscopy", APhA Academy of Pharmaceutical Sciences 37th National Meeting and
Premiere Exposition in Philadelphia, Pennsylvania on October 28-November 1, 1984.
"Utilization of Short-Lived Radionuclides and Positron Emission Tomography (PET) in Tissue
Binding Studies and Disposition of Drugs.", Eli Lilly Company, Indianapolis, Indiana,
November 5, 1984.
“Mechanism of Action of Povidone Iodine", Abbott Laboratories, Chicago, Illinois, January 9,
1985.
"Studies on the Behavior of a Floating Tablet in the GI Tract in Man:, Shering Plough
Corporation, Bloomington, New Jersey, March 21, 1985.
"In Vivo Disposition and Toxicologic Considerations of N-methyl- pyrrolidone with Aromatic
Compounds and its Potential in Drug Delivery", GAF Corporation, Wayne, New Jersey, April
24-26, 1985.
"Peptidyl Carbamate Esters as Elastase Inhibitors", NIH Workshop on Elastase Inhibitors for
Treatment of Emphysema, sponsored by the Division of Lung Diseases, National Heart, Lung
and Blood Institute, Rockville, Maryland, June 10-11, 1985.
"Peptidyl Carbamates Incorporating Amino Acid Isosteres: Novel Specific Elastase Inhibitors",
American Chemical Society, Boston, MA., August 17-22, 1985.
"Disposition and Metabolism of N-Methylpyrrolidone in the Rat", American Chemical Society
Meeting, Boston, MA., August 17-22, 1985.
"Gamma Scintigraphy: Applications to Studies on the G.I. Transit Time of Drug Dosage
Forms", American Pharmaceutical Association, Academy of Pharmaceutical Sciences, Invited
Speaker, October 20-24, 1985, Minneapolis, MN.
"Peptidyl Carbamates Incorporating Amino Acid Isosteres: Novel Specific Elastase
Inhibitors", American Pharmaceutical Association, Academy of Pharmaceutical Sciences,
October 20-24, 1985.
"Synthesis of Fluorinated Putrescine Analogues as Potential Tumor Imaging Agents",
American Pharmaceutical Association, Academy of Pharmaceutical Sciences, October 20-24,
1985, Minneapolis, MN.
"Design and Synthesis of Specific Acrosin Inhibitors", American Pharmaceutical Association,
Academy of Pharmaceutical Sciences, October 20-24, 1985, Minneapolis, MN.
"The pH Dependent Cyclization and Hydrolysis of 1-Aspartyl-1-Phenylalanine Methyl Ester",
American Pharmaceutical Association, Academy of Pharmaceutical Sciences, October 20-24,
1985, Minneapolis, MN.
9

"Systematic Approach in Developing Sustained Release Dosage Forms, Part I: Determination
of Gastro-Intestinal Transit Time", American Pharmaceutical Association, Academy of
Pharmaceutical Sciences, October 20-24, 1985, Minneapolis, MN.
"Neutron Activation as a Method of Radiolabeling Intact Tablets for External Imaging",
American Pharmaceutical Association, Academy of Pharmaceutical Sciences, October 20-24,
1985, Minneapolis, MN.
"The Role of External Scintigraphy in the Development of Novel Pharmaceutical Dosage
Forms", Smith Kline and French Pharmaceutical Company, Philadelphia, PA., February 19,
1986.
"The Role of External Scintigraphy in the Development of Novel Pharmaceutical Dosage
Forms", Burroughs-Welcome Company, Greenville, NC, February 4, 1986.
"In Vivo Behavior of Theophylline Beads After Oral Administration to dogs.", Higuchi
Research Conference, Lake Ozark, MO, March 9-12, 1986.
"The Role of External Scintigraphy in the Development of Novel Pharmaceutical Dosage
Forms", Food and Drug Administration, Center for Drugs and Biologics Scientific Seminar
Program, Rockville, Maryland, May 14, 1986.
"Novel Proposed Curricula in Medicinal Chemistry", 87th Annual American Association of
Colleges of Pharmacy Meeting in Toronto, Canada, July 13-18, 1986.
"Development of Controlled Release Oral Delivery Systems", 13th International Symposium
on Controlled Release of Bioactive Materials", August 3-8, 1986 in Norforlk, VA.
"Utilization of Short-lived Radionuclides in In Vivo Disposition of Drugs, University of
Texas, Anderson Cancer Center, Houston, Texas, September 9, 1986.
"Gamma Scintigraphy and the Design of Novel Dosage Forms", Rochester Institute of
Technology, October 2, 1986, Rochester, NY.
"Stereochemical Considerations in the Design of Novel Elastase Inhibitors", FDA, Drug
Manufacturing and Controls Seminar, Nov. 6, 1986
"Neutron Activation", Seminar, FDA, November 13, 1986, Washington,DC.
"Synthesis of Novel PVP Derivatives for Site-Specific Delivery of Drugs" GAF Chemical
Corporation, Wayne, New Jersey, January 21, 1987.
"Solubilization of Aromatic Compounds with Novel PVP Derivatives" Abbott Laboratories,
Chicago, Illinois, January 28, 1987.
"Neutron Activation and External Scintigraphy" and "Potential of NMR in Drug Formulation
and Imaging", Higuchi Research Conference, Lake Ozark, Missouri, March 15, 1987.
"New Techniques in Drug Metabolism", Eli Lilly Company, Indianapolis, IN, February 25,
1987.
"Studies on the Behavior of Orally Administered Controlled Release Dosage Forms Utilizing
Non Invasive Techniques", Syntex Research Symposium, April 3, 1987.
"Complexation Behavior of N-Methylpyrrolidone with Aromatic Compounds in Isooctane
Solutions," A. Hawi, D. Grant, T. Newcomer and G.A. Digenis, 2nd International Symposium
on Povidone, Lexington, KY, April 12-15,
"The Use of High Field NMR in Studying the Nature of Complexation Between PVP and
Aromatic Compounds", G. Martin, G.A. Digenis and B.J. Agha, 2nd International Symposium
on Povidone, Lexington, KY, April 12-15, 1987.
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"Kinetic and Mechanistic Studies on the Aid-hydrolysis of N-Vinyl-2-pyrrolidone", A. Hawi, D.
Wells, G.A. Digenis, D.H. Hoffman and R. Neudert. 2nd International Symposium on
Povidone, Lexington, KY, April 12-15, 1987.
"Disposition and Metabolism of N-Vinyl-2-pyrrolidone in the Rat", G.A. Digenis, J.
McClanahan and D. Wells", 2nd International Symposium on Povidone, Lexington, KY, April
12-15, 1987.
"Evaluation of the Mutagenicity of N-Methyl-2-pyrrolidone and 4-(methylamino) butanoic
Acid in the Sames Salmonella/Microsome Assay". D.A. Wells, H.F. Thomas and G.A. Digenis.
2nd International Symposium on Povidone, Lexington, KY, April 12-15, 1987.
"Disposition and Metabolism of N-Methyl-2-pyrrolidone in the Rat:, D. Wells and G.A.
Digenis, 2nd International Symposium on Povidone, Lexington, KY, April 12-15, 1987.
"Recent Advances in Non-Invasive Techniques for Studying the In Vivo Behavior of Drug
Delivery Systems" NATO Advanced Study Institute, Cape Sourion, Greece, June 18, 1987 -
July 1, 1987.
"Neutron Activation and Perturbed Angular Correlation", Drug Delivery and Gastrointestinal
Transit Meet, Davos, Switzerland, March 16, 1988.
"Design and Synthesis of Specific Elastase Inhibitors", Institute of Macromolecular
Chemistry, Prague, Czechoslovakia, March 21, 1988.
"Receptor Level Pharmacokinetics Using a 11C Diazepine Receptor Agonists", Charles
University, Prague, Czechoslovakia, March 22, 1988.
"Design and Synthesis of Novel Elastase Inhibitors", Biotechnology Institute of UNIDO,
Trieste, Italy, March 23, 1988.
"Use of Gamma Scintigraphy and Radiotracers in the Design of Novel drug Delivery Systems",
Victorpharma, Trieste, Italy, March 25, 1988.
"Assessment of the Migration of Indium-Labelled Spermatozoa Using External Scintigraphy in
Female Rabbits", B.A. Walter, G.W. Gregory, P.M. Zavos and G.A. Digenis, The American
Fertility Society Annual Meeting, Atlanta, Georgia, October 8-13, 1988. "Design and
Synthesis of Novel Elastase Inhibitors, University of Minnesota, Minneapolis, Minnesota, May
3, 1988.
"Synthesis of Carbon-11 Alprazolam. A Benzodiazepine REceptor Agonist. W. Banks, T.J.
Tewson, G. Digenis, J. Fleishaker, 7th International Symposium on Radiopharmaceutical
Chemistry, Groningen, The Netherlands, July 4-8, 1988.
"Synthesis of Some Novel HLE Inhibitors", Z. Li, B.J. Agha and G.A. Digenis, American
Association of Pharmaceutical Scientists Annual Meeting, Orlando, Florida, October 30-
November 6, 1988. Pharm. Res. Supplement, 5, 10:S-40, October, 1988.
"Stability of Aspartame in Simulated Soft Drink Formulations", S.J. Savidge and G.A.
Digenis, American Association of Pharmaceutical Scientists Annual Meeting, Orlando,
Florida, October 30-November 6, 1988. Pharm. Res. Supplement, 5, 10:S-71, October, 1988.
"Polymer-bound Peptidyl Carbamates as Elastase Inhibitors", M. Grimmett, B. Agha, F.
Rypacek, B. Banks and G. Digenis, American Association of Pharmaceutical Scientists
Annual Meeting, Orlando, Florida, October 30-November 6, 1988. Pharm. Res. Supplement,
5, 10:S-40, October, 1988.
"Pharmacokinetics of a Single Representative Oligomer of Nonoxynol-9 Following I.V.
dministration", B. Walter, B.J. Agha and G.A. Digenis, American Asociation of
Pharmaceutical Scientists Annual Meeting, Orlando, Florida, October 30-November 6, 1988.
Pharm. Res. Supplement, 5, 10:S-187, October, 1988.
11

"Disposition and Pharmacokinetics of Tetrafluoroputrescine in Mice", Helen Yip, Amale A.
Hawi and George A. Digenis, American Association of Pharmaceutical Scientists Annual
Meeting, Orlando, Florida, October 30-November 6, 1988. Pharm. Res. Supplement, 5, 10:S-
185, October, 1988.
"Identification of a Major Metabolite of N-methylpyrrolidone", D.A. Wells, A. Hawi and G.A.
Digenis, American Association of Pharmaceutical Scientists Annual Meeting, Orlando,
Florida, October 30-November 6, 1988. Pharm. Res. Supplement, 5, 10:S-208, October,
1988.
"Evaluation of Sm-153 Enteric Coated Tablet in Man by External Scintigraphy", E. Sandefer,
R.M. Beihn, J. Tossounian, K. Igbal, A.W. Malick and G.A. Digenis, American Association of
Pharmaceutical Scientists Annual Meeting, Orlando, Florida, October 30-November 6, 1988.
Pharm. Res. Supplement, 5, 10:S-106, October, 1988.
"Design of Inhibitors of Human Leukocyte Elastase (HLE)", Gordon Conference, Ventura, CA,
February 20-24, 1989 (invited speaker).
"Recent Attempts to Achieve Site Specific Delivery in the GI Tract of Man: Sandoz
Pharmaceutical Company, Basel, Switzerland, June 2, 1989 (invited speaker).
"The In Vivo Behavior of Multiparticulate Formulations Versus Single Unit Dose Forms", G.A.
Digenis, Vectorpharma, Trieste, Italy, June 6, 1989 (invited speaker).
"Polymer-mediated Delivery of Human Leukocyte Inhibitors to the Lungs", NATO Advanced
Studies Institute, July 1, 1989, Cape Sounion Beach, Greece (Invited conference speaker).
"The In Vivo Behavior of Multiparticulate Formulations versus Single Unit Dosage Forms",
Associazione Farmaceutici Industrial Meeting, Milan, Italy October 25, 1989.
"Studies on Gastric Residence Time of New Polysaccharidic Matrices in Dogs by Gamma
Scintigraphy: In Vitro - In Vivo Correlation", P. Esposito, E. Sandefer, N. Darwazeh and G.A.
Digenis, Presented at AAPS Meeting, Atlanta, GA, October 22-26, 1989. Pharm. Res.
Supplement, 6, 9:S-163, September, 1989.
"Evaluation of Cellulose Acetate Trimellitate (CAT) as a New Enteric Polymer by Scintigraphic
Technique, and its Effect on the Pharmacokinetics of 5-ASA", S.Z. Masih, E. Sandefer, G.A.
Digenis, R.M. Beihn, T.S. Foster, N.M. Clipse, C. Fleenor, SH. Wu and J.C. Gilmer",
Presented at AAPS Meeting, Atlanta, GA, October 22-26, 1989. Pharm. Res. Supplement, 6,
9:S-137, September, 1989.
“Study of the Formulation Factors Affecting Conclusions about the Absorption Site of an Oral
Delivery System by Scintigraphic Technique Alone", S.Z. Masih, G.A. Digenis, E. Sandefer
and R.M. Beihn, Presented at the AAPS Meeting, Atlanta, GA, October 22-26, 1989. Pharm.
Res. Supplement, 6, 9:S-174, September, 1989.
"Evaluation of Two Artificial Tears in the Human Eye by Gamma Scintigraphy", A.A. Hawi,
T.J. Smith and G.A. Digenis, Presented at AAPS Meeting, Atlanta, GA, October 22-26, 1989.
Pharm. Res. Supplement, 6, 9:S-125, September, 1989.
"Erythromycin Bioavailability and Small Intestine Transit Dependency: An Evaluation by
Gamma Scintigraphy", E. Sandefer, R. Beihn, A. Parr, B. Scheinthal, I. Sellasie, U. Iyer, R.
Nesbitt and G.A. Digenis, Presented at AAPS Meeting, Atlanta, GA, October 22-26, 1989.
Pharm. Res. Supplement, 6, 9:S-155, September, 1989.
"High Performance Liquid Chromatographic Method for the Simultaneous Quantitation of
Acetaminophen and Riboflavin in Human Plasma", S. L. Way, H. B. Kostenbauder and G.A.
Digenis, Presented at AAPS Meeting, Atlanta, GA, October 22-26, 1989. Pharm. Res.
Supplement, 6, 9:S-12, September, 1989.
12

"HPLC Separation of Nonoxynol-9 and In Vitro Spermicidal Assessment of Selected
Oligomers", B.A. Walter, B.J. Agha, P.M. Zavos and G.A. Digenis, Presented at AAPS Meeting,
Atlanta, GA, October 22-26, 1989. Pharm. Res. Supplement, 6, 9:S-12, September, 1989.
"Assessment of Site Specific Drug Delivery Using Gamma Scintigraphy", Schering Inc.,
Newark, New Jersey, November, 1989.
"Positron Emission Tomography in Drug Dynamic Studies using Gamma Scintigraphy",
Schering, Inc., Newark, New Jersey, November 1989.
"In Vivo Behavior of Multiparticulate and Single Dosage Forms in the Gastrointestinal Tract
of Man", Tokyo, Japan, April, 1990.
"Attempts to Achieve Site Specific Delivery in the GI Tract of Man", Tanabe Laboratories,
Osaka, Japan, April 1990.
"A Quantitative Comparison of Artificial Tear Clearance Rates in Humans Using Gamma
Scintigraphy", ARVO Convention (Association for Research in Vision and Ophthalmology),
Sarasota, Florida, May 4, 1990.
"A Polymer-bound Elastase Inhibitor is Effective in Inhibiting Human Neutrophil-Elastase
Induced Emphysema", Pulmonary Emphysema: The Rationale for Therapeutic Interventions
Meeting in Orlando, Florida, May 15-18, 1990.
"A Synthetic Leukocyte Elastase Inhibitor", Association for Research in Vision and
Ophthalmology (ARVO) Annual Meeting, Sarasota, Florida, April 26-May 2, 1991.
"Methods to Study the Disposition of Peptides and Proteins from Orally Administered
Formulations", 1991 Capsugel Symposium, New Brunswick, New Jersey, September 26,
1991.
"Methods to Study the Disposition of Peptides and Proteins from Orally Administered
Formulations", 1991 Capsugel Symposium, Tokyo, Japan, October 18, 1991.
"Recent Advances in the Use of Povidone and Povidone-iodine in Anti-HIV Research"
International Specialty Products (GAF), Wayne, New Jersey, May 7-8, 1992.
"Synthesis of Specific Inhibitors of Human Neutrophil Elastase and Their Polymer-Medicated
Lung Delivery", 5th Cyprus Conference on New Methods in Drug Research, May 10-16, 1992,
Larnaca, Cyprus.
"The Use of Gamma Scintigraphy to Establish Product Claims and Explain Oral Drug
Absorption Anomalies", Food and Drug Administration, June 11-12, 1992, Rockville,
Maryland.
"Drug Development: From Bench to a Marketed Product", 6th Panhellenic Pharmaceutical
Congress, June 17-24, 1992, Athens, Greece.
"The Use of Gamma Scintigraphy to Establish Product Claims and Explain Oral Drug
Absorption Anomalies", Bristol-Myers Squibb Pharmaceutical Research Institute, October 23,
1992, New Brunswick, New Jersey.
"Gamma Scintigraphy: What Have We Learned From It In The Last Ten Years", November 11,
1992, Capsugel Symposium, Osaka, Japan.
"The Use of Gamma Scintigraphy to Establish Product Claims and Explain Oral Drug
Absorption Anomalies", November 13, 1992, Kyoto University, Kyoto, Japan.
"Current Status on Targeted drug Delivery to the GI Tract", Warner-Lambert Capsugel
Symposium, Short Hills, New Jersey, April 22, 1993, (Symposium Chairman).
"Crosslinking of Hard Gelatin Capsules with Aldehydes", Capsugel Symposium, Paris,
France, April 27-28, 1993.
13

"Latest News on Small Intestinal Transit Time", 1993 Capsugel Symposium, Nagai Memorial
Hall, Shibuya, Tokyo, Japan, May 10, 1993.
"The Use of Gamma Scintigraphy to Establish Product Claims and Explain Oral Drug
Absorption Anomalies", 33rd Associazione Farmaceutici Industria Symposium, Le Conchiglie
Congress Centre, Riccione, Italy, June 2-4, 1993.
"Gamma Scintigraphy and Neutron Activation Techniques in the in-vivo Assessment of Orally
Administered Dosage Forms", Center for Drug Evaluation and Research, Food and Drug
Administration, Rockville, Maryland, November 2, 1993.
JAGO, Vienna, Austria, "A Novel Oral Controlled Release Drug Delivery System with Gastric
Retentive Properties", May 2-3, 1994.
Capsugel Board of Advisors Meeting, Rome, Italy, "Chemistry of Gelatin Cross-linking", May
4-6, 1994.
Sixth Cyprus Conference on New Methods in Drug Research, Limassol, Cyprus, "Current
Advances in Drug Targeting to the GI Tract", May 7-14, 1994.
Controlled Release Society, Nice, France, "Comparative Scintigraphic Evaluation of Aromatic-
Azo Polymers and Eudragit (R) S-100 for Colonic Release in beagles", June 24-July 1, 1994.
Second European Pharmaceutical Technology Conference, Barcelona, Spain, "Current Status
on Oral Solid-Dosage Forms of Peptides: Biological and Formulation Factors", October 18-19,
1994.
FDA, Rockville, MD, "Cross-Linking of Gelatin Capsules", December 1, 1994.
"Defining Variable Oral Absorption by Concomitant Evaluation of GI Transit Using
Pharmacoscintigraphy", American Association of Pharmaceutical Scientists/FDA Workshop
on Evaluation of Orally Administered Highly Variable Drugs and Drug Formulations,
Arlington, VA, March 5-8, 1995.
"Development of a Novel Controlled Release Formulation of Nonoxynol-9 and Oligomers"
University of Athens, College of Pharmacy, Athens, Greece, May, 1995.
"The Role of Pharmacoscintigraphy in the Assessment of the in vivo Behavior of Drug
Formulations", University of Athens, College of Pharmacy, Athens, Greece, May, 1955.
"The Role of Rhinoscintigraphy in Nasal Drug Delivery", present at Focus Group Meeting,
November 7, 1995, Miami Beach Convention Center, Miami, FL.
"New Approaches for the Design of Antacid Formulations", September 7, 1995, Warner-
Lambert Company, Morris Plaines, NJ.
"Biopharmaceutical Drug Classification and International Drug Regulation", Capsugel/FDA,
Princeton, NJ, May 17, 1995.
"Assessment of Behavior of Oral Dosage Forms by Gamma Scintigraphy", Merck
Frosst Canada, Inc., Dorval, Quebec, Canada, September 1, 1995.
Participant as a member of the panel which discussed the Biopharmaceutics Drug
Classification and International Drug Regulation - organized by Capsugel, May 17, 1995.
Presented mini-course on oral drug delivery, presented to Graduate Students and Staff,
University of Athens, College of Pharmacy, Athens, Greece, May, 1995.
Review of proposals (Review RFP NICHD-CD-95-8) "Female Controlled Methods -
Development of Novel Vaginal Products to Maintain the Integrity of the Vaginal Ecosystem",
July 11, 1995.
14

The National Institute of Child Health and Human Development, Contraceptive Development
Branch, Rockville, MD, "Enhancing Vaginal Defense Mechanisms: Immunology &
Physiology", April 9, 1996.
The National Institute of Child Health and Human Development, Contraceptive Development
Branch, Rockville, MD, "Development of spermicidal controlled release formulations with
anti-HIV properties", April 9, 1996.
Bayer Corporation, West Haven, CT, "Methods for evaluation of drug absorption from the
colon", April 18, 1996.
Bausch & Lomb, Rochester, NY, "Radiotracer methodologies to study the in vivo disposition
of ophthalmic drug formulations", April 26, 1996.
Cyprus Pharmaceutical Association, Aegis Pharmaceutical, Nicosia, Cyprus, "Development of
spermicidal controlled release formulations with anti-HIV properties" and "Recent changes in
pharmacy curricula in the USA", May 27-31, 1996.
CRS (Controlled Release Society), Baltimore, MD, "Contributions of gamma scintigraphy in
the design of oral dosage forms: Implications of gastrointestinal transit times", "Technology,
Design and Evaluation of Oral Controlled Release Dosage Forms", August 20-21, 1996.
Pfizer, Inc., Groton, CT, "Capsule Cross-Linking and Effects on Bioequivalence", September
20, 1996,
8th Panhellenic Pharmaceutical Congress, Athens, Greece, "Chemistry of Cross-Linking of
Gelatin and its Implications to Pharmaceutical Systems", October 3-7, 1996.
Endo Labs, Garden City, New York, "Expediting Research and Development of Controlled
Release Formulations by Pharmacoscintigraphy", October 18, 1996.
Nu-kote International, Dallas, Texas, "Advances with Coated Products with Potent Anti-HIV
and Antimicrobial Properties", October 23, 1996.
Schein Pharmaceutical, Inc., "Gelatin Cross-Linking", November 22, 1996.
I.N.D. Management, Inc., Upper Saddle River, New Jersey, "Novel Approaches to the Oral
Delivery of Peptides", March 28, 1997.
Bristol-Myers Squibb, Princeton, New Jersey, "Application of Gamma Scintigraphy in the In
Vivo Evaluation of New Drugs and Their Formulations, March 31, 1997.
University of Athens, Athens, Greece, "Design of Oral Dosage Forms With Guidance From
Pharmacoscintigraphy", April 14, 1997.
European 16th Pharmaceutical Technology Conference, Athens, Greece, "Novel Controlled
Delivery Systems Incorporating High Energy Coprecipitate of Nonoxynol-9 with Potent
Spermicidal and Anti-HIV Properties", April 15, 1997.
European 16th Pharmaceutical Technology Conference, Athens, Greece, "Development of a
Three Compartment Oral Sustained Release Delivery System for Nifedipine", April 15, 1997.
European 16th Pharmaceutical Technology Conference, Athens, Greece, "A Definite Method
to Evaluate Enteric Delivery Systems Targeting the Proximal Small Intestine", April 15, 1997.
I.N.D. Management, Inc., Upper Saddle River, New Jersey, "The Oral Delivery of Peptides",
April 28, 1997.
38th Symposium of the Association of Industrial Pharmacy, Florence, Italy, May 22, 1997.
Second Pancyprian Pharmaceutical Conference, Nicosia, Cyprus, "Gelatin-Cross-Linking and
its Relevance to the Bioavailability of Drugs", May 24, 1997.
SmithKline Beecham Pharmaceuticals, King of Prussia, PA, September 8, 1997.
15

Technol, Inc., Ft. Worth, TX, "First International Symposium on Pharmaceutical Chemistry,
Hacettepe University, Ankara, Turkey, "Synthesis and Mechanism of Action of Novel
Inhibitors of Human Leukocyte Elastase, September 24, 1997.
American Association of Pharmaceutical Scientists Annual Meeting, Boston, MA, "Hard and
Soft Gelatin Capsules", November 5, 1997.
"Recent Advances to Formulation Development Using Gamma Scintigraphy" SmithKline
Beechman Pharmaceuticals, Philadelphia, PA, January 28, 1998.
"Recent Advances in Formulation Development with Gamma Scintigraphy", Annual meeting
of the Academy of Pharmaceutical Sciences and Technology, Tokyo, Japan, March 21-27,
1998.
Attended Meeting of the Medical Advisory Board at Protein Delivery Inc., Durham, NC, April
1, 1998.
Participated in a reviewing panel which judged program grant proposals (graduate and
undergraduate) by Greek Universities in the areas of Pharmacy, Medicine, Dentistry, Nursing
and Allied Health, Ministry of National Development, Athens, Greece, April 15-26, 1998.
Attended Meeting of the Protein Delivery Scientific Advisory Board Meeting, Durham, NC,
April 29, 1998.
"Mechanism Based Design of Novel Inhibitors of Human Leukocyte Elastase", American
Association of Pharmaceutical Scientists Midwest Regional Meeting, May 17-19, 1998.
Invited to Attend Technical Advisory Committee Meeting and review new research proposals,
CONRAD (Contraceptive Research and Development Program), Arlington, VA, June 8-9,
1998.
Attended 25th International Symposium on Controlled Release Society (CRS), Las Vegas, NV,
June 21-24, 1998.
"Studies on Solubilization and Bioavailability Enhancement Through Formulation and
Chemical Approaches", SmithCline Beecham Pharmaceuticals, King of Prussia, PA, July 15,
1998
"Isolation and Identification of the Major Urinary Metabolite of N-Vinyl-2-Pyrrolidinone From
the Conscious Rat", 4th European Congress of Pharmaceutical Sciences, Milan, Italy, Sept
10-14, 1998.
"Radioiodination and Pharmacokinetic Study of a Novel Insulin Derivative in Fasted Beagles",
4th European Congress of Pharmaceutical Sciences, Milan, Italy, Sept 10-14, 1998.
Attended Meeting of the Medical Advisory Board at Protein Delivery Inc., Durham, NC,
September 22, 1998.
Attended American Association of Pharmaceutical Scientists Annual Meeting, San Francisco,
CA, November 14-19, 1998.
Attended Meeting with CONRAD, Arlington, VA, to discuss proposal, December 17, 1998.
Attended 9th International Symposium on Recent Advances in Drug Delivery, Salt Lake City,
Utah, February 22-23, 1999.
"Recent Advances in the Scintigraphic Evaluation of Novel Drug Delivery Systems", Otsuka
Labs, Tokushima, Japan, March 25, 1999.
"The Role of Counterions in the Stability of N-methylpyrridinium Prodrugs" Invited Speaker
at the 14th Annual Meeting of the Academy of Pharmaceutical Technology Sciences,
Okayama City, Japan, March 27, 1999.
16

"Use of a Remote Drug Delivery Capsule (RDDC) for Non-Invasive (GI) Regional Drug
Absorption Studies in Man and Studies on Solubilization and Bioavailability Enhancement
Through Formulation and Chemical Approaches", ONO Pharmaceutical Company, Osaka,
Japan, March 29, 1999.
"Recent Advances in the Scintigraphic Evaluation of Novel Drug Delivery Systems as
Alternatre Routes of Administration", Takeda Pharmaceutical Development Laboratories,
Osaka, Japan, March 29, 1999.
"Gamma Scintigraphy in Drug Development" Invited Speaker to American Association of
Pharmaceutical Scientists (AAPS) Northeast Regional Discussion Group, Rocky Hill, CT, April
25-26, 1999.
Attended Meeting of the Protein Delivery Scientific Advisory Board Meeting, Durham, NC,
April 28, 1999.
"Assessing Extent and Uniformity of Spread of Vaginal Chemical Barriers", Invited Speaker at
the 10th World Congress on Human Reproduction, Salvador, Bahia, Brazil, May 4-8, 1999.
"Novel Techniques to Assess the Extent and Uniformity of Spread of Vaginal Product in
Humans" Invited Speaker, FDA, Washington, DC, June 9, 1999.
Invited to attend CONRAD Technical Advisory Committee Meeting, Washington, DC, June 7-
8, 1999.
"Novel Approaches to Oral Delivery of Therapeutic Proteins and Peptides, Invited speaker at
the American Association of Pharmaceutical Scientists (AAPS) Southeast Conference, June
21, 1999.
Attended Controlled Release Society Meeting, Boston, MA, June 22-24, 1999
Participated in evaluation of proposals in connection with PENED'99 Program to strengthen
research capabilities, Greek Ministry of Development, General Secretary of Research and
Technology, Athens, Greece, June 28-July 9, 1999.
Seminar speaker on the "Chemistry and Biology of Gelatin Cross-Linking", Hoffmann-
LaRoche, Inc., Nutley, NJ, July 22-23, 1999.
"Biological Issues That Affect the Performance of Polymers Used in Oral Drug Delivery",
Invited Speaker at a Symposium on the "Emerging Trends for Polymer Application in Oral
Drug Delivery", National Meeting of the American Association of Pharmaceutical Scientists,
New Orleans, LA, Nov. 16, 1999.
Invited Seminar Speaker, “The Crosslinking of Gelatin Capsules and a New IN-Vitro Two-Tier
Dissolution Medium”, Hoffman-LaRoche Pharmaceutical Company, May 26, 2000
External Evaluator for the Graduate program of the Department of Pharmaceutical
Chemistry, School of Pharmacy, University of Athens, Athens, Greece, June 2000.
External Evaluator for the Program entitled Evaluation of the Educational Activities
(Undergraduate) of the School of Pharmacy, University of Athens, Athens, Greece, June 2000.
Attend Controlled Release Scoeity Annual Meeting, Paris, France, July 7-13, 2000.
17
XV.
RESEARCH AND/OR CREATIVE PRODUCTIVITY
Publications
1. Whitlock, H.W., Jr. and Digenis, G.A., "An Oxidative Amine Fragmentation,"
Tetrahedron Letters, 24, 1521 (1964).

2. Digenis, G.A., Abou-Chaar, C.I. and Helou, N., "Biogenetic Studies on Gramine
Investigation of Certain Strains of Lebanese Barley for Gramine Content," Lebanese
Pharm. J., 9, 47 (1966-67).
3. Abou-Chaar, C.I. and Digenis, G.A., "Alkaloids of an Ipomoea Seed Commonly Known as
Kalandana in Pakistan," Nature, 212, 618 (1966).
4. Digenis, G.A., Faraj, B.A. and Abou-Chaar, C.I., "The Biotransformation of Gramine into
Tryptophan in Barley Shoots," Biochem. J., 101, 27c (1966).
5. Digenis, G.A. and Faraj, B.A., "A Metabolic Pathway of Gramine in Barley," Experientia,
23, 774 (1967).
6. Thorson, R.E., Digenis, G.A., Berntzen, A. and Konyalian, A., "Biological Activities of
Various Lipid Fractions from Echinococcus Granulosus Scolices on In Vitro Cultures of
Hymenolepis Diminuta," J. Parasitology, 54, 970 (1968).
7. Digenis, G.A., "Metabolic Fates of Gramine in Barley I. The Mechanism of Incorporation
of Gramine into Tryptophan in Barley Shoots," J. Pharm. Sci., 58, 39 (1969).
8. Digenis, G.A., "Metabolic Fates of Gramine in Barley II. The Biotransformation of
gramine into Indole-3-carbinol and Indole-3-carboxylic Acid in Barley," J. Pharm. Sci.,
58, 42 (1969).
9. Digenis, G.A., "Benzyl Group Migration in 9-Methyl-10-benzyl-9,10-dihydroacridine," J.
Pharm. Sci., 58, 335 (1969).
10. Digenis, G.A., and Magarian, E.O., "Conformational Preference in N,N-Dimethyl-9-
carboxamide-9, 10-dimethylacridane Determined by NMR Spectroscopy," J. Pharm. Sci.,
58, 1026 (1969).
11. Abou-Chaar, C.I. and Digenis, G.A., "A Course in Biosynthesis of Plant Constituents for
Graduate Students in Pharmacognosy and Pharmaceutical Chemistry," Amer. J. Pharm.
Educ., 31 196 (1967).
12. Digenis, G.A. and Apostolopoulos, A.X., "The Chemcial Bonding of Merrifield's Peptide
Resin to Human Enamel," Abstracts of International Association of Dental Research
(IADR), March 20-23, 1969, Houston, Texas, p. 107.
13. Apostolopoulos, A.X. and Digenis, G.A., "The Silylation of Tooth Enamel and its Effect
on Acid Decalcification," Abstracts of International Association for Dental Research
(IADR), March 20-23, 1969, Houston, Texas, p. 107.
14. Digenis, G.A., Thorson, R.E. and Konyalian, A., "Studies on the Cholesterol Biosynthesis
and Lipid Biochemistry in the Scolex of Echinococcus Granulosus," J. Pharm. Sci., 59,
676 (1970).
15. Digenis, G.A., Konyalian, A. and Thorson, R.E., “In Vivo Transfer of 4-C-Cholesterol
from Mouse Host to Encapsulated Trichinella Spiralis Larvae," Lipids, 5,282 (1970).
16. Miyamoto, M.A., Kostenbauder, H.B., Walstad, D. and Digenis, G.A. "Energy Transfer
Reactions in Aqueous Solution: The Riboflavin Photo-oxidation of an Acridan
Derivative," FEBS Letters, 7, 101 (1970).
17. Apostolopoulos, A.X. and Digenis, G.A., "The Silylation of Human Enamel and Dentine
and its Effect on Acid Dissolution," Arch. Oral Biol., 16, 233 (1971).
18. Kostenbauder, H.B., Jawad, M.J., Sung, P. and Digenis, G.A., "Photochemical Reactions
in Presence of Surfactants and Macromolecules," J. Soc. Cosmet, Chem., 22, 83 (1971).
18

19. Digenis, G.A., Walstad, D.L., Ishaque, M. and Aleem, M.I.H., "Mechanism of Action of
Antipsychotic Drugs on Biological Electron Transport," Biochem. Pharmacol., 20, 919
(1971).
20. Digenis, G.A. and Whitlock, H.W., Jr., "Oxidative Fragmentation of 9-Aminomethylacridan,"
J. Pharm. Sci., 61, 206 (1972).
21. Digenis, G.A., Burkett, J.W. and Mihranian, V., "A Convenient Synthesis of 2- 14 C-
Hordenine," J. Labelled Compounds, 8, 231 (1972).
22. Digenis, G.A. and Mihranian, V., "The Riboflavin Catalyzed Photo- decomposition of 9-
Aminomethylacridan," Tetrahedron Letters, 2049 (1972).
23. Shambhu, M.B., Digenis, G.A. and Moser, R.J., "PMR Spectra of Aromatic N,N-
Dimethylcarboxamides. Evidence for Hindered Rotation and Anisotropic Effects Caused
by Additional Phenyl Rings," J. Org. Chem., 38, 1229 (1973).
24. Shambhu, M.B. and Digenis, G.A., "Insoluble Resins in Organic Syntheses I.
Preparation and Reactions of Polymeric Anhydrides," Tetrahedron Letters, 1627 (1973).
25. Digenis, G.A., Shambhu, M.B. and Koganty, R.R., "Mechanism of Action of Clomacran
Phosphate (SK+F 14,336) on Biological Electron Transport," 8th International Congress
of Chemotherapy, Athens, Greece, September 8-14, 1973.
26. Koganty, R.R., Shambhu, M.B. and Digenis, G.A., "Reactions of Acid Halides and
Chloroformates Involving an Intermediate with Dimethylformamide," Tetrahedron
Letters, 4511 (1973).
27. Shambhu, M.B. and Digenis, G.A., "Insoluble Resins in Organic Syntheses II.
Preparation and Reactions of Mixed Carbonic-Carboxylic Anhydride on Polystyrene," J.
Chem. Soc., (Chem. Com.), 619 (1974).
28. Digenis, G.A., Amos, H.E., Yang, K., Mitchell, G.E., Little, C.D., Swintosky, J.V., Parish,
R.C., Schelling, G.T., Dietz, E.M. and Tucker, R.E., "Methionine Substitutes in
Ruminant Nutration 1. Stability of Nitrogenous Compounds Related to Methionine
During In Vitro Incubation with Rumen Micro-organisms." J. Pharm. Sci., 63, 745
(1974).
29. Digenis, G.A., Amos, H.E., Mitchell, G.E., Swintosky, J.V., Yang, K., Schelling, G.T. and
Parish, R.C., "Methionine Substitutes in Ruminant Nutrition 2. Stability of Nonnitrogenous
Compounds Related to Methionine During In Vitro Incubation with Rumen
Micro-organisms," J. Pharm. Sci., 63, 751 (1974).
30. Shambhu, M.B., Koganty, R.R. and Digenis, G.A., "Conformational Analysis of Acridan
Derivatives by Nuclear Magnetic Resonance Spectroscopy. A Relationship Between
Conformation and Pharmacological Activity," J. Med. Chem., 17, 805 (1974).
31. Amos, H.E., Little, C.O., Digenis, G.A., Schelling, G.T., Tucker, R.E. and Mitchell, G.E.,
"Methionine, DL-Methionine for Ruminants," J. Animal Sci., 39, 612 (1974).
32. Koganty, R.R. and Digenis, G.A., "A Convenient Preparation of 18 0-Dimethyl-formamide,"
J. Labelled Compounds, 10, 419 (1974).
33. Amos, H.E., Schelling, G.T., Digenis, G.A., Swintosky, J.V., Little, C.O. and Mitchell,
G.E., "Methionine Replacement Value of N-Acetyl Methionine and Homo-cysteine
Thiolactone HCl for Growing Rats," J. Nutrition, 105, 577 (1975).
34. Kook, C.S., Reed, M.F. and Digenis, G.A., "The Preparation of 18 F-Haloperidol," J. Med.
Chem., 18, 533 (1975).
35. Digenis, G.A., Reed, M.F., Pettit, W.A. and Mortara, R.H., "Preparation of Nitrosso- 13 N
Labeled Nitrosoureas," J. Med. Chem., 18, 1029 (1975).
19

36. Digenis, G.A., Shakhshir, S., Miyamoto, M.A. and Kostenbauder, H.B., "Anaerobic
Photo-decomposition of an Acridan Drug Through Energy Transfer," J. Pharm. Sci., 65,
247 (1976).
37. Digenis, G.A. and Swintosky, J.V., "Drug Latentiation," in Handbook of Experimental
Pharmacology (Concepts in Biochemical Pharmacology), Vol. 28/3, J.R. Gillette and B.B.
Brodie, editors, Springer-Verlag Berlin, New York (1975).
38. Theodorakis, M.C., Beihn, R.M., Digenis, G.A., DeLand, F.H., Shambhu, M. and Wilson,
L.C., "A New Radiodiagnostic Agent to Evaluate Gastric Emptying Time," J. Nucl. Med.,
16, 575 (1975).
39. Digenis, G.A., Kook, C.S. and Reed, M.F., "The Synthesis of F-18 Haloperidol," J.
Nucl.Med., 16, 525 (1975).
40. Digenis, G.A., Williams, M. and Shambhu, M.B., "Application of a Chemically Reactive
Resin as a Cigarette Filter in the Isolation of a Bioactive Tobacco Smoke Fraction,
"Chemistry and Industry, 2, 69 (1976).
41. Shambhu, M.B., Digenis, G.A., Bulati, D.K., Sabharwal, P.S. and Bowman, K.,
"Chemical Combinations of 2,4-D and Polystyrene. Preparation and Application for the
Control of Duckweed," J. Agr. and Food Chem., 24, 666 (1976).
42. Shambhu, M.B., Digenis, G.A. and Benner, J.F., "Chemically Altered Polystyrene Resins
as Selective Cigarette Filters," Tobacco International, 178, 75 1976).
43. Casey, D.L., Beihn, R.M., Digenis, G.A. and Shambhu, M.B., "Method for Monitoring
Hard Gelatin Capsule Disintegration Times in Humans using External Scintigraphy,"
Journal of Pharmaceutical Sciences, 65, 1412 (1976).
44. Digenis, G.A., "Stable and Short-Lived Isotopes in the Study of Tissue Distribution," J.
Toxicol. Environ. Health, 2, 757 (1977).
45. Digenis, G.A., Beihn, R.M., Theodorakis, M.C. and Shambhu, M.B., "Use of 99m Tc-
Labeled Triethylenetetramine-Polystyrene Resin for Measuring the Gastric Emptying
Rate in Humans," J. Pharm. Sci., 66, 442 (1977).
46. Pettit, W.A., Tilbury, R.S., Digenis, G.A. and Mortara, R.H., "A Convenient Synthesis of
13N-BCNU," J. Labelled Compd. and Radiopharmaceuticals, Vol. XIII, 119 (1977).
47. Shambhu, M.B., Theodorakis, M.C. and Digenis, G.A., "Polystyrene Resins with
Immobilized Polyamines: Preparations, Characterization, and Ability to Bind Cu (II)
Ions," J. Poly. Sci. Chem., 15, 525 (1977).
48. Triplett, J.W., Digenis, G.A., Layton, W.J. and Smith, S.L., "Carbon-13 Chemical Shift
Assignments for the Bisulfite Adducts of Uracil, 5-Deuterouracil, 5-Fluorouracil and 5-
Chlorouracil," Spectroscopy Letters, 10, 141 (1977).
49. Triplett, J.W., Chow, N.H., Smith, S.L. and Digenis, G.A., "Carbon-13 NMR Investigation
of the Bisulfite Induced Changes in Yeast RNA," Biochemical and Biophysical Research
Communications, 77, No. 4, 1170 (1977).
50. Triplett, J.W., Smith, S.L., Layton, W.J. and Digenis, G.A., "Carbon-13 Nuclear Magnetic
Resonance Investigations into the Interactions of Bisulfite with Pyrimidine Nucleosides
and Nucleotides," J. Med. Chem., 20, 1594 (1977).
51. Shambhu, M.B., Digenis, G.A., Benner, J.F. and Keene, C., "Functionalized
Macroreticular Resins as Effective and Selective Traps for Gaseous Tobacco Smoke
Components," J. Macromol, Sci.-Chem., A11, 2293 (1977).
20

52. Casey, D.L., Digenis, G.A., Gwilt, P.R. and Perrier, D.G., "A Convenient Synthesis of
Deuterium Labelled Diphenylhydantoin," J. of Labelled Compounds and
Radiopharmaceuticals, 13, 623 (1977).
53. Martin, G.E., Shambhu, M.B. and Digenis, G.A., "Polymer Bound Carbonic Anhydrides
in N-Acyhlation of 7-Aminocephalosporanic Acid," J. Pharm. Sci., 67, 110 (1978).
54. Triplett, J.W., Mack, S.W., Smith, S.L. and Digenis, G.A., "Synthesis of Carbon-13
Labelled Uracil, 6,7-Dimethyllumazine, and lumichrome, Via a Common Intermediate:
Cyanoacetylurea," J. Labelled Compd. and Radiopharmaceuticals, 14, 35 (1978).
55. Triplett, J.W., Chow, N.H., Smith, S.L. and Digenis, G.A., "Determination of pK Values
for the Bisulfite Adducts of Cytidine 5'- Monophosphate by Carbon-13 Nuclear Magnetic
Resonance," J. Org. Chem., 43, 3411 (1978).
56. Martin, G.E., Shambhu, M.B., Shakhir, S.R. and Digenis, G.A., "Polymer- Bound
Carbonic-Carboxylic Anhydride Functions. Preparation, Site-Site Interactions and
Synthetic Applications," J. Org. Chem., 43, 4571 (1978).
57. Papageorgiou, V.P., Winkler, A., Sagredos, A.N. and Digenis, G.A., "Studies on the
Relationship of Structure to Antimicrobial Properties of Naphthaquinones and
OtherConstituents of Alkanna Tinctoria Tausch," Planta Medica, 35, 56 (1979).
58. McQuinn, Roy L., Cheng, Ying-Chi, and Digenis, George A., "Convenient Preparations of
Several N-Nitroso Compounds," Synthetic Communications, 9, 25 (1979).
59. Triplett, J.W., Digenis, G.A., Layton, W.J. and Smith, S.L., " 13 C-NMR Studies of
Bisulfite-Pyrimidine Addition Reactions: Stereoselective Formation and Reactions of the
5-Halouridines," J. Org. Chem., 43, 4411 (1978).
60. Digenis, G.A. and Issidorides, C.H., "Some Biochemical Aspects of N-Nitroso
Compounds," Bio-organic Chemistry, 8, 97-137 (1979).
61. McQuinn, Roy L., Feola, Jose, and Digenis, George A., "The Effect of Vitamin A on the
Uptake of a Water Soluble and Lipid Soluble Nitrosourea by the EMT6 Mouse Mammary
Tumore," Int. J. Rad. Oncology Biology and Physics, 5, 1577 (1979).
62. Digenis, G.A., McQuinn, R.L., Freed, B., Tilbury , R.S., Reiman, R.E. and Cheng, Y.C. ,
“Preparation of 13 N-labeled Streptozotocin and Nictosocarbaryl”, J. of Labelled Compd.
and Radiopharmaceuticals, 16" , 95 1979).
63. Vincent, S.H., Shambhu, M.B. and Digenis, G.A., "Synthesis of [ 82 Br] Bromperidol and
Preliminary Tissue Distribution Studies in the Rat," J. Medicinal Chemistry, 23, 75
(1980).
64. Theodorakis, M.C., Digenis, G.A., Beihn, R.M., Shambhu, M.B. and DeLand, F.H., "Rate
and Pattern of Gastric Emptying in Humans Using 99m Tc-Labeled Triethylenetetraamine-Polystyrene
Resin," J. Pharm. Sciences, 69, 568 (1980).
65. Jay, M., Layton, W.J. and Digenis, G.A., "Exchange Between Labelled Cyanide and the
Nitrile Function of Acetonitrile," Tetrahedron Letters, 21, 2621 (1980).
66. Papageorgious, V.P. and Digenis, G.A., "Isolation of two New Alkannin Esters from
Alkanna Tinctoria," Planta Medica, 39, 81 (1980).
67. Triplett, J.W., Vogt, Donald D., Digenis, G.A., Coupal, J. and Easley, Albert G., "The
Undergraduate Nuclear Pharmacy Curriculum at the University of Kentucky College of
Pharmacy," American Journal Pharmaceutical Education, 44, 154 (1980).
68. Theodorakis, M.C., Beihn, R.M. and Digenis, G.A., " 99m Tc-labeled Treithylenetetramine
Polystyrene: An Agent for Imaging Segments of the Gastrointestinal Tract in Humans,"
Int. J. Nuclear Med. and Biology, 7, 374 (1980).
21

69. Digenis, G.A., "Toxicology Studies: Utilization of Short-Lived Radionuclides in the
Assessment of the Safety and Disposition of Novel Products," in Research Frontiers in
Fertility Regulation, G.I. Zatuchni, Miriam H. Labbok, John J. Sciarra, eds., pp. 23-31
Harper and Row Publishers, N.Y., (1980).
70. Casey, D.L., Digenis, G.A., Wesner, D.A., Washburn, L.C., Chaney, J.E., Hayes, R.l. and
Callahan, A.P., "Preparation and Preliminary Tissue Studies of Optically Active C-11-Dand
L-Phenylalanine," Int. J. Appl. Rad. and Isotopes, 32(5), 325 (1981).
71. Jay, M., Chaney, J.E. and Digenis, G.A., "Development of Methodology for Synthesis of
[α]-Labeled Phenethylamine," Int. J. Appl. Rad. and Isotopes, 32(5), 345 (1981).
72. Digenis, G.A., Vincent, S.H., Kook, C.S., Reiman, R.E., Russ, G.A. and Tilbury, R.S.,
"Preparation and Tissue Distribution Studies of 18 F Haloperidol and 18 F β-(4-
fluorobenzoyl)-propionic Acid," J. Pharm. Sci., 70, 985 (1981).
73. Digenis, G.A., Cheng, Y.C., McQuinn, R.L., Freed, B.R. and Tilbury, R.S., "In Vitro and
In Vivo Disposition of 13 N-Labeled Nitrosoureas and Nitrosocarbamates," Proceedings of
the Fifth Workshop Conference, Tobacco and Health Research Institute, University of
Kentucky, November 1, 1979 (received 9-22-81).
74. Beihn, R.M. and Digenis, G.A., "Noninvasive Dissolution Measurement Using Perturbed
Angular Correlation," J. Pharm. Sci., 70, 1325 (1981).
75. Digenis, G.A., Cheng, Y.C., McQuinn, R.L., Freed, B.R. and Tilbury, R.S., " 13 N-Labeling
of a Substituted Nitrosourea, Its Carbamate, and Nitrosocarbaryl: In Vivo and In Vitro
Studies," in Short-Live Radionuclides in Chemistry and Biology, John W. Root and
Kenneth A. Krohn, eds., pp. 351-367, Advances in Chemistry Series 197(1981).
76. Jay, M., Chaney, J.E., Digenis, G.A., Washburn, L.C., Byrd, B.L. and Callahan, A.P.,
"Synthesis and Brain Uptake of Carbon-11 Phenethylamine," J. Labelled Compd.
Radiopharm., 18 (1-2):237 (1981).
77. Digenis, G.A., "The Utilization of Short-Lived Radionuclides in the Assessment of
Formulation and In Vivo Disposition of Drugs," Radionuclide Imaging in Drug
Research, edited by C.G. Wilson, J.G. Hardy, with S.S. Davis and M. Frier (Croom Helm,
London, 1982) pp. 103-143.
78. Digenis, G.A., Goto, Rensuke, Chaney, James E. and Tamemasa, Osamu, “Rapid
Enzymatic Preparation of [ 14 C]D-Leucine from [ 14 C]DL-Leucine," J. Pharm. Sci., 71, 818
(1982).
79. Jay, M. and Digenis, G.A., "Enhanced Entrapment of a Quarternary Ammonium
Compound in Liposomes by Ion Pairing," J. Pharm. Sci., 71:958-960 (1982).
80. Tamemasa, Osamu, Digenis, George A., Tezuka, Masakatsu, Takeda, Atsushi, Chaney,
James E. and Goto, Rensuke, "Differential Radioactivity Uptake from 14 C-Labeled D-
and L-Leucine by the Pancreas of Animals Pretreated with Pancreatitis-causing Agents,"
Chem. Pharm. Bull., 30, 2561-2528 (1982).
81. Freed, Barry R., McQuinn, Roy L., Tilbury, Roy S. and Digenis, George A., "Distribution
of 13 N in Rat Tissues Following Intravenous Administration of Nitroso-Labeled BCNU,"
Cancer Chemotherapy and Pharmacology, 10, 16-21 (1982).
82. Jay, M., Beihn, R.M., Synder, G.A., McClanahan, J.S., Digenis, G.A., Caldwell, L. and
Mlodozeniec, A., "In Vitro and In Vivo Suppository Studies with Perturbed Angular
Correlation and External Scintigraphy, Int. J. Pharmaceutics, 14, 343-347 (1983).
83. Chaney, James E., Kobayashi, Kunio, Goto, Rensuke and Digenis, G.A., "Tumor
Selective Enhancement of Radioactivity Uptake in Mice Treated with α-Difluoro-
22

methylornithine Prior to Administration of 14 C-Putrescine," Life Sciences, 32, 1237-1241
(1983).
84. Smith, M.F., Bryant, S., Welch S. and Digenis, G.A., "Labelling Suspended Aerosol
Particles with Short-Lived Radionuclides for the Determination of Particle Deposition."
J. Pharm. Sci., in press (1983).
85. Agha, B.J.and Digenis, G.A., "Studies on the Interaction of PVP Related Lactams with
Aromatic Compounds Using NMR Spectroscopy," in First International Symposium on
Povidone, Digenis, G.A. and Ansell J., edits., pp. 53-60, University of Kentucky Press,
Lexington, Kentucky (1983).
86. McClanahan, J., Chaney, J., Blecher, L. and Digenis, G.A., "Disposition of N-
vinylpyrrolidinone in the Rat," in First International Symposium on Povidone, Digenis
G.A. and Ansell J., edits., pp. 250-268, University of Kentucky Press, Lexington,
Kentucky, (1983).
87. Digenis, G.A., Rokem, J.S., Eckert D. and Blecher, L., Studies on the Association of 14 C-
Povidone- 131 I-Iodine Complex with Red Blood Cells and Bacterial Membranes," in First
International Symposium on Povidone, Digenis, G.A. and Ansel J., edits., pp. 302-311,
University of Kentucky Press, Lexington, Kentucky (1983).
88. McArthur, W.A., Crawdord, L.D., Jay M. and Digenis, G.A., "Povidone as an Implant Aid
for Cardiac Pacing Leads," in First International Symposium on Povidone, Digenis, G.A.
and Ansell. J., edits., pp. 450-455, University of Kentucky Press, Lexington, Kentucky,
1983.
89. McClanahan, J., Lin, Y.C. and Digenis, G.A., "Disposition of N-Vinyl-2-Pyrrolidinone in
the Rat," Drug and Chemical Toxicology, 7, No. 2 (1984), 129-148.
90. Goto, Rensuke, Takeda, Atsushi, Tamemasa, Osamu, Chaney, James E. and Digenis,
George A., "Stimulating Effects of Inosine, Uridine and Glutamine onthe Tissue
Distribution of Radioactive D-Leucine in Tumor Bearing Mice," Radioisotopes, 33, No. 2
(1984), p. 25-28.
91. Jay, Michael, Ogawa, Naotake, Bogardus, Joseph B., Mlodozeniec, Arthur R. and
Digenis, George A., "Anisotropy of indium-111 Cetyltrimethylammonium Bromide
Solutions," Int. J. of Pharmaceut., 19 (1984), p. 97-100.
92. Agha, Bushra J., Garbolas, George A., Wets, Kathleen, and Digenis, George A.,
“Preparation of [ 131 I] Iodinated Nonoxynol-9, J. Labelled Compounds and
Radiopharmaceuticals, 1984.
93. Fell, John T. and Digenis, Geroge A., "The In Vivo Behavior of Solid Oral Dosage Forms,"
Int. J. of Pharmaceut., 1984.
94. Jay, Michael, and Digenis, George A., "Safety Assessment and Bio-distribution of
Povidone as a Coating Material for Cardiac Pacing Leads, Biomaterials, Medical Devices
and Artificial Organs, 11, #4, 1984.
95. Mlodozeniec, A.R., Caldwell, L., Jay, Michael, Beihm, R.M. and Digenis, George A.,
"Noninvasive Monitoring of the In Vivo Release Characteristics of Rectal Drug Delivery
Devices" Recent Advances in Drug Delivery Systgems, Edited by James M. Anderson
and Sung Wan Kim, Plenum Publishing Corporation, 1984, 321-341.
96. Takeda, Atsushi, Goto, Rensuke, Tamemasa, Osamu, Chaney, James E. and Digenis,
George A., "Biological Evaluation of Radiolabeled D-Methionine as a Parent Compound
in Potential Nuclear Imaging," Radioisotopes, 33, #4, (1984) p. 25-30.
23

97. Tsuji, K., Agha, B.J., Shinogi, M. and Digenis, G.A., "Peptidyl Carbamate Esters: A New
Class of Specific Elastae Inhibitors,", Biochemical and Biophysical Research
Communications, 111, No. 2, 571-576 (1984).
98. Digenis, George A., Jay, Michael, Beihn, Robert M., Tice, Thomas R. and Beck, Lee R.,
"External Scintigraphy in the Study of Long-Acting Contraceptive Delivery Systems,"
Long-Acting Contraceptive Delivery Systems, Edited by G.I. Zatuchni, Alfredo
Goldsmith, J.D. Shelton and John J. Sciarra, Harper and Row, (1984), 256-264.
99. Farcasiu, Dan, Marino, G., Rose, K.D., Digenis, G.A. and Jay, M., "On the Exchange of
Cyanide with Acetonitrile: A Test of Theoretical Calculations," Tetrahedron, 40, 1482-
1491 (1984).
100. Caldwell, Larry J., Parr, Alan, Beihn, Robert M., Agha, Bushra J., Mlodozeniec, Arthur
R., Jay, Michael, and Digenis, George A., "Drug Distribution and Biliary Excretion
Pattern of a Cyclic Somatostatin Analog: A Comparison of 14 C Labeled Drug 131 I
Iodinated Drug Analog", Pharmaceutical Research, 2:80-83 (1985).
101. Hussain, Munir, Chaney, James E., Digenis, George A. and Layton, John, “Mechanistic
Study on Exchange Between Labeled Cyanide and Nitriles, J. of Labelled Compounds
and Radio-pharmaceuticals,, XXII, #10, 983-993 (1985).
102. Parr, A., Jay, M., Digenis, G.A.and Beihn, R.M., Radiolabelling of Intact Tablets by
Neutron Activatin for In Vivo Scintigraphic Studies, J. Pharm. Sci., 74, 590 (1985).
103. Shinogi, Masaki, Agha, Bushra, Tsuji, Kiyoshi and Digenis, George. Assessment of
Antiprotease Activity in Some Carbamate Derivatives, J. Pharm. Sci., 74, No. 4, 482
(1985).
104. Wells, David A., Chaney, James E. and Digenis, George A., Synthesis of [4- 3 H]-2-
Pyrrolidinone, [4- 3 H]-N-Methyl-2-Pyrrolidinone and N-[ 14 C-Methyl]-2-Pyrrolidinone,
Journal of Labelled Compounds and Radiopharmaceuticals, Vol. XXII, No. 4 (1985).
105. Jay, Michael, Fell, John T. and Digenis, George A., Studies on the Dissolution of Drugs
from Tablets Using Perturbed Angular Correlation. Pharmaceutical Research, 2, 75-78
(1985).
106. Jay, Michael, Beihn, Robert M., Digenis, George A., DeLand, Frank H., Caldwell, Larry
and Mlodozeniec, Arthur R., Disposition of Radiolabelled Suppositories in Humans, J.
Pharm. Pharmacol., 37: 266-268 (1985).
107. Jay, M., Digenis, G.A., Foster, T.S. and Antonow, D.A. Retrograde Spreading of
Hydrocortisone Enema in Inflammatory Bowel Disease, Dig. Dis. Sci., 31:139-144
(1986).
108. Wells, David A., Garbolas, George A. and Digenis, George A., Analysis of the
Radiochemical Puerity of [ 14 C]Chloroform and [1,2- 14 C]Dibromoethane by
Radiomonitored HPLC, J. of Chromatography, 356, 367-371 (1986).
109. Digenis, George A., Agha, Bushra J., Tsuji, Kiyoshi, Kato, Masayuki and Shinogi,
Masaki, Peptidyl Carbamates Incorporating Amino Acid Isosteres as Novel Elastase
Inhibitors, J. of Medicinal Chemistry, 29, 1467-74 (1986).
110. Nassar, Munir N., Agha, Bushra J. and Digenis, George A.," Synthesis of [Carbonyl- 14 C]
Labelled Carbonate and Carbamate Esters, J. of Labelled Compounds and
Radiopharmaceuticals,, Vol. XXIII, #6, 667-676 (1986).
111. Digenis, G.A., Hawi A. A., Yip. H. and Layton, W.J., Detection of Tetrafluoroputrescine
in RBCs by Fluorine-19 Nuclear Magnetic Resonance Spectroscopy, Life Sciences, 38,
#25, 2307-2309 (1986).
24

112. Digenis, G.A., Wells, D.A., Ansell, J.M. and Blecher, L., "Disposition of [ 14 ]Povidone After
Oral Administration in the Rat" Food and Chemical Toxicology, 25 #3, 241-243 (1987).
113. Sangekar, S., Vadino, W.A., Chaudry, I., Parr, A., Beihn, R. and Digenis, G., "Evaluation
of the Effect of Food and Specific Gravity of Tablets on Gastric Retention Time", Int. J.
of Pharmaceut., 35, 187-191 (l987).
114. Saito, K., Digenis, G.A., Hawi, A.A. and Chaney, J., "Synthesis of Some Fluorinated
Putrescine Analogues", J. of Fluorine Chem., 35, 663-667 (l987).
115. Hawi, Amale A., Grant, David J.W., Newcomer, Timothy and Digenis, George A.,
"Complexation Behavior of N-Methylpyrrolidone With Aromatic Compounds in Isooctane
Solutions", in Second International Symposium on Povidone, G.A. Digenis and B. Agha,
edits., pp. 168-180, University of Kentucky Press, Lexington, Kentucky, (1987).
116. McNamara, Patrick J., Foster, Thomas S., Digenis, George A., Patel, Rajani B., Craig,
William A., Welling, Peter G., Rapaka, Rao S., Prasad, Vadlamani K. and Shah, Vinrod
P., "Influence of Tablet Dissolution on Furosemide Bioavailability: A Bioequivalence
Study", Pharmaceutical Research, 4, #2, 150-153 (1987).
117. Peggy A. Domstad, Wei-Jen Shih, Laurie Humphries, Frank DeLand and George A.
Digenis, "Radionuclide Gastric Emptying studies in Patients with Anorexia Nervosa", J.
Nucl. Med., 28:816-819 (1987).
118. David A. Wells and George A. Digenis, "Disposition and Metabolism of Double-Labeled
[ 3 H and 14 C] N-Methyl-2-Pyrrolidinone in the Rat", Drug Metabolism and Disposition, 16,
243 (1988).
119. Hawi, Amale A., Yip, Helen, Sullivan, Teresa S. and Digenis, George A., "Development of
an HPLC Assay for the Analysis of Tetrafluoroputrescine - A Putrescine Analog",
Analytical Biochemistry, 172, 235-240 (1988).
120. Walter, B.A., Agha, B.J. and Digenis, G.A., "Disposition of [C-14] Nonoxynol-9 after I.V.
or Vaginal Administration to Female Sprague Dawley Rats: Toxicology and Applied
Pharmacology, 96, 258-268 (1988).
121. Shih, Wei-Jen, Humphries, Laurie, Digenis, George A., Castellanos, F.X., Domstad,
Peggy A., and DeLand, Frank H., "Tc-99m Labeled Triethelene Tetraamine Polysterene
Resin Gastric Emptying Studies in Bulimia Patients" Eur. J. Nucl. Med., 13 192-196
(1988).
122. Wells, David A., Thomas, Harvey F., Digenis, George A., "Evaluation of N-Methyl-2-
Pyrrolidinone and 4-(Methylamino) Butanoic Acid in The Ames Salmonella/Microsome
Assay", Journal of Applied Toxicology 8, 135-139, (1988).
123. Banks, William R., Hawi, Amale A., and Digenis, George A., " Synthesis of Carbon-13
and Carbon-14 Labelled Triazolo-1,4-Benzodiazepines" Journal of Labelled Compounds
and Radiopharmaceuticals, 27, #4, 407-416, (1989).
124. Banks, William R., and Digenis, George A., "Development of Methodology for the Rapid
Incorporation of Carbon-13 into 1,2,4-Triazolo Systems from Carbon Dioxide",
Tetrahedron Letters, 30, 6473-6476 (1989).
125. Hussain, Munir A., Changey, James E., Jay, Michael, and Digenis, George A., "Rapid
Synthesis of Radiolabeled Phenylethanolamine", Journal of Labelled Compounds and
Radiopharmaceuticals, 28 #4, 373-376 (1989).
126. Parr, Alan F., Digenis, George A., Sandefer, Erik P., Ghebre-Sellassie, Isaac, Iyer, Uma,
Nesbitt, Russell U., and Scheinthal, Bernard M., "Manufacture and Properties of
Erythromycin Beads Containing Neutron-Activated Erbium-171", Pharmaceutical
Research, 7, #3, 264-269 (1990).
25

127. Digenis, G.A., Sandefer, E.P., Parr, A.F., Beihn, R., McClain, C., Scheinthal, B.M.,
Ghebre-Sellassie, I., Iyer, U., Nesbitt, R.U., and Randinitis, E., "Gastrointestinal
Behavior of Orally Administered Radiolabeled Erythromycin Pellets in Man As
Determined by Gamma Scintigraphy", J. Clin, Pharmacol. 30, 7, 621-631 (1990).
128. Banks, William R., Tewson, Timothy J., and Digenis, George A., "Radiosynthesis of a
11C-Labelled Benzodiazepine Receptor Agonist: 1-[ 11 C]-Alprazolam", Appl. Rad. and Isot.,
41, 719-725 (1990).
129. Walter, B.A., and Digenis, G.A., "Part I: HPLC Separation, Identification and
Quantitation of Oligomeric Components of the Spermicide Nonoxynol-9",
Pharmaceutical Research, 8, #3, 409-411 (1991).
130. Walter, Brian A., Hawi, Amale A., Zavos, Panayiotis M., and Digenis, George A., "Part II:
Solubilization and In Vitro Spermicidal Assessment of Nonoxynol-9 and Selected
Fractions Using Rabbit Spermatozoa", Pharmaceutical Research, 8, #3, 403-408, (1991).
131. Banks, William R., Rypacek, Frantisek, and Digenis, George A., "Synthesis of a Carbon-
14 Labelled Peptidyl Carbamate Human Leukocyte Elastase Inhibitor and Its
Immobilization on a Tritiated Water Soluble Polymer" Journal of Labelled Compounds
and Radiopharmaceutical, 29, #4, 381-391, 1991.
132. Banks, William R., Hawi, Amale A., and Digenis, George A., "An Anomalous Reaction of
7-Chloro-2-hydrazono-5-phenyl-1,2-dihydro-3H-1,4-benzodiazepine with Sodium
Acetate and 1,1'-Carbonyldiimidazole", J. Heterocyclic Chemistry, 28, 533-535, 1991.
133. Digenis, George A., and Sandefer, Erik, "Gamma Scintigraphy and Neutron Activation
Techniques in the In Vivo Assessment of Orally Administered Dosage Forms", in Critical
Reviews in Therapeutic Drug Carrier Systems, 7, 309-346 (1991) CRC Press, Inc.
134. Lucey, E.C., Stone, P.J., Digenis, G.A., and Snider, G.L., "A Polymer-Bound Elastase
Inhibitor Is Effective in Preventing Human Neutrophil Elastase-Induced Emphysema", in
Pulmonary Emphysema, The Rationale for Therapeutic Intervention, edited by George
Weinbaum, Ralph E. Giles, and Robert D. Krell, Vol. 624, pp 341-342, (1991) The New
York Academy of Science Press.
135. Digenis, George A., Sandefer, Erik P., Beihn, Robert M.,and Parr, Alan F., "Dual-Isotope
Imaging of Neutron-Activated Erbium-171 and Samarium-153 and the in vivo
Evaluation of a Dual-Labeled Bilayer Tablet by Gamma Scintigraphy", Pharmaceutical
Research, 8, #10, 1335-1339, 1991.
136. Yamakita, Hirokazu, Page, Richard C., and Digenis, Geroge A., "Determination of N-
Vinyl-2-Pyrrolidinone (NVP) in Rat and Dog Plasma by High-Performance Liquid
Chromatography", Journal of Liquid Chromatography, 15, 83-99 (1992).
137. Wells, David A., Hawi, Amale A., and Digenis, George A., "Isolation and Identification of
the Major Urinary Metabolite of N-Methylpyrrolidinone in the Rat", Drug Metabolism
and Disposition, 20, 124-126 (1992).
138. Nassar, Munir N., Agha, B.J., and Digenis, G.A., "Effects of Structural Variations as the
Rates of Enzymatic and Nonenzymatic Hydrolysis of Carbonate and Carbonate Esters",
J. Pharm. Sci, 81, 295-298 (1992).
139. Cejkova, J., Lojda, Z., Vacik, J., Digenis, G.A., and Dropcova, S., "Histochemical
Changes in the Rabbit Cornea and Plasmin Activity in the Tear Fluid During Contact
Lens Wear-Favorable Influence of Protease Inhibitors (Aprotinin, PC5, elastinal)".
Histochemistry, 97, 69-76 (1992).
140. Banks, William R., Yamakita, Hirokazu, and Digenis, George A., “Metabolism and
Distribution of 1-[ 14 C]Alprazolam in Rats", J. Pharm. Sci., 797-801 (1992).
26

141. Stone, Phillip J., Lucey, Edgar C., Noskova, Dagmar, Digenis, George A. and Snider,
Gordon L., "Covalently Linking a Peptidyl Carbamate Elastase Inhibitor to a Hydrophilic
Polymer Increases Its Effectiveness in Preventing Emphysema and Secretory Cell
Metaplasia in the Hamster", Am. Rev. Respir. Dis., 146:457-461 (1992).
142. Digenis, G.A. and Rodis, N., "Drug Design: From Bench to the Market Place",
Pharmakeftiki, 5, 145-154 (1992),
143. Digenis, George A., McClanahan, J.S., and Chen, Pei-Lin, "Synthesis of [2,3,4,5- 14 C]-1-
Vinyl-2-Pyrrolidinone", Journal of Labelled Compounds and Radiopharmaceutials, Vol.
XXXIII, No. 1, 11-17, (1993).
144. Banks, William R., Clore, L. Stanton, Dadey, Eric J., Digenis, George A., "Tritiated and
Deuterated Alprazolam. The Use of Deuterium NMR to Study Isotope Exchange in
Tritiated Alprazolam", Appl. Radiat. Isot. Vol. 44, No. 7, pp. 1021-1027, (1993).
145. Kato, Masayuki, Agha, Bushra J., Abdul-Raheem, Abdul-K., Tsuji, Kiyoshi, Banks,
William R., and Digenis, George A., "Peptidyl Carbamates as Novel Elastase Inhibitors:
Structure-Activity Relationship Studies", J. of Enzyme Inhibition, Vol 7, pp. 105-130,
(1993).
146. Digenis, George A., Banks, William R., Kato, Masasuki, Rencher, William F., and Agha,
Bushra J., "Peptidyl Carbamates as Human Leukocyte Elastase Inhibitors: Design and
Synthesis of Desmosine-Like Tetrapeptidyl Carbamate Inhibitors", J. Enzyme Inhibition,
Vol. 7, pp 275-301, (1993).
147. Noskova, Dagmar, Mohammadi, Fatemeh, Savidge, Sandra J., Digenis, George A.,
"Mechanistic Study of HLE Inhibition Using Dual Labeled Macromolecular Inhibitor", J.
Enzyme Inhibition, Vol. 7, pp 303-309, (1993).
148. Koch, Kevin M., Parr, Alan F., Tomlinson, Julie J., Sandefer, Erik P., Digenis, George A.,
Donn, Karl H., and Powell, J. Robert, "Effect of Sodium Acid Pyrophosphate on
Ranitidine Bioavailability and Gastrointestinal Transit Time", Pharm. Res., 10:1027-
1030, (1993).
149. Rypacek, Frantisek, Banks, William R., Noskova, Dagmar, and Digenis, George A.,
"Synthetic Macromolecular Inhibitors of Human Leukocyte Elastase. 1. Synthesis of
Peptidyl Carbamates Bound to Water-Soluble Polymers: Poly-α,ß-[N-(2-hydroxyethyl)-
D,L-aspartamide] and Poly-α-[N 5 -(2-hydroxyethyl)-L-glutamine]", J. Medicinal
Chemistry, 37, pp 1850-1856 (1994).
150. Digenis, George A., Gold, Thomas B., Shah, Vinod P., "Cross-Linking of Gelatin
Capsules and Its Relevance to Their In Vitro-In Vivo Performance", J. Pharm. Sciences,
83, 7:915-921 (1994).
151. Calis, Unsal, Finch, John R., Soltis, Edward E., Digenis, George A., "Synthesis of Novel
Aminopropyl-guanidine Derivatives with Potential Antihypertensive Activity", Pharm.
Res., 11, 8:1211-1215 (1994).
152. Buice, Robert G., Jr., Gold, Thomas B., Lodder, Robert A., Digenis, George A.,
"Determination of Moisture in Intact Gelatin Capsules by Near-Infrared
Spectrophotometry", Pharm. Res., 12, 1:161-163, 1995.
153. Finch, John R., Dadey, Eric J., Smith, Sanford L., Harrison, Lester I., Digenis, George
A., "Dynamic Monitoring of Total-Body Absorption by 19 F NMR Spectroscopy: One Hour
Ventilation of HFA-134a in Male and Female Rats", Magnetic Res. in Med., 409-413,
1995.
154. Dobbs, Frank R., Banks, William, Fleishaker, Joseph C., Valentine, Alan D., Kinsey,
Berma M., Franceschini, Mark P., Digenis, George A., Tweson, Timothy J., "Studies with
27

[ 11 C]Alprazolam: an Agonist for the Benzodiazepine Receptor, Nucl. Med. Biol., Vol. 22,
No. 4, pp. 459-566, 1995.
155. Finch, John R., Banks, Wiliam R., Hwang, Dah-Ren, Satter, Martin R., Ezzidene, Bilal,
Mantil, Joseph C., Digenis, George A., Synthesis and in vivo disposition studies of 18 F-
labeled HFA-134a", Appl. Radiat. Isot., 46:4, pp. 241-248, 1995.
156. Thanoo, Bagavathikanun C., Doll, Walter J., Mehta, Rahul C., Digenis, George A., and
DeLuca, Patrick P., "Biodegradable Indium-111 Labeled Microspheres for
Evaluation of Distribution and Elimination", Pharm. Res. 12:12 2060-2064, 1995.
157. Sun, Jim X., Walter, Brian, Sandefer, Erik P., Page, Richard C., Digenis, George A., Ryo,
U. Yun, Cipriano, Alexandra, Maniara, Wieslawa M., Powell, Mark L., Chan, Keith,
"Explaining Varialbe Absorption of a Hypolipidemic Agent (CGP 43371) in Healthy
Subjects by Gamma Scintigraphy and Pharmacokinetics", J Clin Pharmacol, 36:230-
237, 1996.
158. Gold, Thomas B., Smith, Stanford L., Digenis, George A., "Studies on the Influence of
pH and Pancreatin on 13 C-Formaldehyde-Induced Gelatin Cross-Links Using Nuclear
Magnetic Resonance", Pharmaceutical Development and Technology, 1, 21-26, 1996.
159. Zavos, P.M., Correa, J.R., Nosek, D., Mohammadi, F., Digenis, G.A., "Comparative
Spermicidal Performance of Iodinated and Non-iodinated Contraceptive Formulations of
Nonoxynol-9 Coprecipitated with Polyvinylpyrrolidone", Contraception, 54, (1), 39-41,
1996.
160. Chen, Peilin, Tian, Zuguang, Digenis, George A., Tai, Hsin-Hsiung, "Enzyme
Immunoassay of Two Nicergoline Metabolites, 10α-Methoxy-9, 10-Dihydrolysergol
(MDL) and 1-Methyl-10α-Methoxy-9, 10-Dihydrolysergol (MMDL), Research
Communications in Molecular Pathology and Pharmacology, 92, 3, 315-328, June,
1996.
161. Zavos, P.M., Correa, J.R., Nosek, D., Mohammadi, F., Digenis, G.A., "Assessment of New
Formulations of Nonoxynol-9 Coprecipitated with Polyvinylpyrrolidone and Iodine as
Possible Vaginal Contraceptives", Fertility and Sterility, 66, 6, 729-733, 1996.
162. Mohammadi, Fatemeh, Nosek, Dagmar, Digenis, George A., "Synthetic Macromolecular
Inhibitors of Human Leukocyte Elastase. 2. Effect of Loading of a Peptidyl Carbamate
Inhibitor and Molecular Size of Polymer Backbone on its Inhibitory Capacity", accepted
for publication in Journal of Enzyme Inhibition, 11, 183-198 (1997).
163. Gold, Thomas B., Buice, Jr., Robert G., Lodder, Robert A., Digenis, George A.,
"Determination of Extent of Formaldehyde-Induced Crosslinking in Hard Gelatin
Capsules by Near-Infrared Spectrophotometry", Pharm. Res., 14, 8:1046-1050, 1997.
164. Santus, G., Lazzarini, C., Bottoni, G., Sandefer, E.P., Page, R.C., Doll, W.J., Ryo, U.Y.
and Digenis, G.A., "An in vitro - in vivo investigation of oral bioadhesive controlled
release furosemide formulations", Eur. J. Pharm. Biopharm. , 44:39-52 (1997).
165. Gold, Thomas B., Buice, Robert G., Jr., Lodder, Robert A., Digenis, George A.,
"Detection of Formaldehyde-Induced Crosslinking in Soft Elastic Gelatin Capsules Using
Near-Infrared Spectrophotometry", Pharm. Dev. & Tech., 3(2), 209-214 (1998).
166. Digenis, George A., Sandefer, Erik P., Page, Richard C. and Doll, Walter J., "Gamma
Scintigraphy: An Evolving Technology in Pharmaceutical Formulation Development -
Part I", Pharmaceutical Science & Technology Today, 1(3), 100-107, June 1998.
167. Digenis, George A., Sandefer, Erik P., Page, Richard C. and Doll, Walter J., "Gamma
Scintigraphy: An Evolving Technology in Pharmaceutical Formulation Development -
Part II", Pharmaceutical Science & Technology Today, 1(4), 160-165, July 1998.
28

168. Marathe, Punit H., Sandefer, Erik P., Kollia, Georgia E., Greene, Douglas S., Barbhaiya,
Rashmi H., Lipper, Robert A., Page, Richard C., Doll, Walter J., Ryo, U.Y. and Digenis,
George A., "In Vivo Evaluation of the Absorption and Gastrointestinal Transit of
Avitriptan in Fed and Fasted Subjects Using Gamma Scintigraphy", J. of
Pharmacokinetics and Biopharmaceutics, 26(1), 1-20, 1998.
169. Parr, Alan F., Sandefer, Erik P., Wissel, Paul, McCartney, Mike, McClain, Craig, Ryo,
U.Y., and Digenis, George A., "Evaluation of the Feasibility and Use of a Prototype
Remote Drug Delivery Capsule (RDDC) for Non-Invasive Regional Drug Absorption
Studies in the GI Tract of Man and Beagle Dog", Pharmaceutical Research, 16(2), 266-
271, 1999.
170. Digenis, G.A., Nosek, D., Mohammadi, F., Darwazeh, N.B., Anwar, H.S., and Zavos,
P.M., "Novel Vaginal Controlled-Delivery Systems Incorporating Coprecipitates of
Nonoxynol-9", Pharm. Dev. and Tech., 4(3) 421-430, 1999.
171. Li-Pan, Zhanyi Sky, Joshi, Hemant V., and Digenis, George A., "Synthesis and
Mechanism of Action of Novel Thiocarbamate Inhibitors of Human Leukocyte Elastase",
J. Enzyme Inhibition, 15, 63-77,1999.
172. Digenis, George A., Sandefer, Erik P., Page, Richard C., and Doll, W.J., "Recent
Advances in Formulation Development with Gamma Scintigraphy", Pharm. Tech. Japan,
Part I, 15(8), 1125-1133, (1999).
173. Digenis, George A., Sandefer, Erik P., Page, Richard C., and Doll, W.J., "Recent
Advances in Formulation Development with Gamma Scintigraphy", Pharm. Tech. Japan,
Part II, 15(9), 1289-1293, (1999).
174. Digenis, George A., Sandefer, Erik P., Page, Richard C., and Doll, W.J., "Recent
Advances in Formulation Development with Gamma Scintigraphy", Pharm. Tech. Japan,
Part III, 15(10), 1453-1457, (1999).
175. Digenis, George A., Sandefer, Erik P., Page, Richard C., and Doll, W.J., "Recent
Advances in Formulation Development with Gamma Scintigraphy", Pharm. Tech. Japan,
Part IV, 15(11), 1633-1638, (1999).
176. Digenis, G.A., Sandefer, E.P., Page, R.C., Doll, W.J., Gold, T.B., and Darwazeh, N.B.,
“Bioequivalence Study of Stressed and Nonstressed Hard Gelatin Capsules Using
Amoxicillin as a Drug Marker and Gamma Scintigraphy to Confirm Time and GI
Location of In Vivo Capsule Rupture”, Pharm. Res., 17, 5:572-582, 2000.
177. Rodis, Nikolaos P. and Digenis, George A., “Synthesis and In-Vitro Evaluation of Novel
Low Molecular Weight Thiocarbamates as Inhibitors of Human Leukocyte Elastase”, J.
of Enzyme Inhibition, 16:2, 95-105, 2001.
178. Fowler, Phillip T., Matsumoto, Kazuya, Page, Richard C., and Digenis, George A.,
“Synthesis of Novel Iodinated Derivatives of Nonoxynol-9 and Their Bioavailability in
Rats”, Nucl. Med. Biol, 29(7):771-775, 2002.
179. Qasem, J.G., Bummer, Paul M., and Digenis, George A., “Kinetics of Paclitaxel 2-Nmethylpyridinium
Mesylate Decomposition”, PharmSciTech, 4(2), 2003.
180. Fowler, Phillip T., Doncel, Gustavo F., Bummer, Paul M., and Digenis, George A.,
“Complexation of Nonoxynol-9 with Polyvinylpyrroliodone to Decrease Vaginal Irritation
Potential”. PharmSciTech, 4(3), 2003.
181. Hussain, M.A., Chang, R-K, C., Sandefer, E., Page, R.C., and Digenis, G.A., “Evaluation
of the in vivo disintegration of solid dosage forms of a bile acid sequestrant in dogs
using γ-scintigraphy and correlation to in vitro disintegration”. Pharm. Res. 20 (3), 460-
464, 2003.
29

182. Gao, Z.J., Hussain, M.D., Motheram, R., Gray, D.A., Denedek, I.H., Fiske, W.D., Doll,
W.J., Sandefer, E., Page, R.C., and Digenis G.A., “Investigation of human
pharmacoscientigraphic behavior of two tablets and a capsule formulation of a high
dose, poorly water soluable/high permeable drug (Efaverenz)”, J. Pharm. Sci., (in press).
183. Al-Ghananeem, A.M., Sandefer, E.P., Doll, W., Page, R.C., Chang, Y., and Digenis, G.A.,
“Gamma Scintigraphy for Testing Bioequivalence: A Case Study on Two Cromolyn
Sodium Nasal Spray Preparations”, Inter. J. of Pharmaceutics, 2008 (in press).
30
Books and Chapters
1. Digenis, G.A. and Swintosky, J.V., "Drug Latentiation," in Handbook of Experimental
Pharmacology (Concepts in Biochemical Pharmacology), Vol. 28/3, J.R. Gillette and B.B.
Brodie, editors, Springer-Verlag Berlin, New York (1975).
2. Digenis, G.A., "Toxicology Studies: Utilization of Short-lived Radionuclides in the
Assessment of the Safety and Disposition of Novel Products," in Research Frontiers in
Fertility Regulation, G.I. Zatuchni, Mirian H. Labbok, John J. Sciarra, eds., pp. 23-31,
Harper and Row Publishers, New York (1980).
3. Digenis, G.A., "The Utilization of Short-lived Radionuclides in the Assessment of
Formulation and In Vivo Disposition of Drugs," Radionuclide Imaging in Drug Research,
Edited by C.G. Wilson, J.G. Hardy, with S.S. Davis and M. Frier (Croom Helm, London,
1982) pp. 103-143.
4. Digenis, G.A. and Ansell, J., editors, "Proceedings of the First International Symposium
on Povidone," Lexington, Kentucky, University of Kentucky, 1983.
5. Mlodozeniec, A.R., Caldwell, L., Jay, Michael, Beihn, R.M., and Digenis, George A.;
Noninvasive Monitoring of the In Vivo Release Characteristics of Rectal Drug Delivery
Devices, Recent Advances in Drug Delivery Systems, Edited by James M. Anderson and
Sung Wan Kim, Plenum Publishing Corporation, (1984).
6. Digenis, George A., Jay, Michael, Beihn, Robert M., Tice, Thomas R., Beck, Lee R.,
External Scintigraphy in the Study of Long-Acting Contraceptive Delivery Systems.
Long-Acting Contraceptive Delivery Systems, Edited by G. I. Zatuchni, Alfredo
Goldsmith, J.D. Shelton and John J. Sciarra, Harper and Row, (1984).
7. Digenis, G.A. and Agha, B.J., editors, "Proceedings of the Second International
Symposium on Povidone" University of Kentucky, Lexington, Kentucky. (1987).
8. Digenis, G.A., Parr, A., Jay, M., "Neutron Activation Methods for Evaluation of
Pharmaceutical Dosage Forms", in Drug Delivery to the Gastrointestinal Tract, edits.
J.G. Hardy, S.S. Davis and C.G. Wilson, Ellis Horwood Press, Chichester, England
1989, pp 111-119.
9. Digenis, George A. and Sandefer, Erik, "Gamma Scintigraphy and Neutron Activation
Techniques in the In Vivo Assessment of Orally Administered Dosage Forms", in Critical
Reviews in Therapeutic Drug Carrier Systems, 7, 309-346 (1991) CRC Press, Inc.
10. Digenis, George A., "In Vivo Behavior of Multiparticulate Versus Single-Unit Dose
Formulations", in Multiparticulate Oral Drug Delivery, Edited by Isaac Ghebre-Sellassie,
Marcel Dekker, Inc., 1994, pp 333-355.
11. Digenis, George A.and Erik P. Sandefer, "Acceleration of Pharmaceutical Research and
Development with Application of Gamnma Scintigraphy", in European Pharmaceutical
Contractor, pp 22-32, 1999.

12. Digenis, George A., “Gamma Scintigraphy for Estimation of Vaginal Drug Distribution”
in Current Knowledge in Reproduction Medicine, A.M. Coutinho and P. Spinola, eds.,
Elsevier Science B.V., New York, pp. 263-266, 2001.
31
Patents
1. Digenis, G.A., Shambhu, M.B. and Theodorakis, M.C., "Radiodiagnositc Agent," U.S.
Patent #4,115,540 (Sept. 19, 1978).
2. Digenis, G.A., Shambhu, M.B., "Tobacco Smoke Filter Material," U.S. Patent #4,202,356
(May 13, 1980).
3. Digenis, G.A., Shambhu, M.B., "Tobacco Smoke Filter Material," Canadian Patent S.N.
257,102 (May 12, 1981).
4. Digenis, George A., Agha, Bushra J., "Peptide Elastase Inhibitors and Methods", U.S.
Patent #4,643,991, (February 17, 1987).
5. Digenis, George A., Doll, Walter J., and Hawi, Amale. "3-Hydroxy-N-methylpyrrolidone
and Use as Transdermal Enhancer", U.S. Patent #4,973,708, (November 27, 1990).
6. Digenis, George A. and Agha, Bushra J. "Novel Peptidyl Carbamate Inhibitors of the
Enzyme Elastase", U.S. Patent No. 5,008,245, (April 16, 1991).
7. Digenis, George A., Doll, Walter A., Hawi, Amale, "3-Hydroxy-N-methylpyrrolidone and
Preparation Thereof", U.S. Patent #5,032,402, (July 16, 1991).
8. Digenis, George A., Agha, Bushra J., Banks, William R., and Rypacek, Frantisek.
"Polymer Bound Elastase Inhibitors", U.S. Patent #5,162,307. (November 10, 1992).
9. Digenis, George A. and Digenis, Alexander G., "High Energy Coprecipitate of Nonoxynol
Oligomer, PVP and Iodine Having Contraceptive and Potent Anti-HIV Properties", U.S.
Patent #5,380,523. (January 10, 1995).
10. Digenis, George A. and Digenis, Alexander G., "Coated Products with Potent Anti-HIV
and Antimicrobial Properties, U.S. Patent #5,492,692. (February 20, 1996).
11. Digenis, George A. and Rodis, Nikolas P., "Low Molecular Weight Thiocarbamates as
Inhibitors of Elastase, Uses and Methods of Synthesis", U.S. Patent #5,539,123. (July
23, 1996).
12. Digenis, George A. and Noskova, Dagmar, "Multicompartment Hard Capsule with
Control Release Properties", U.S. Patent #5,672,359. (September 30, 1997).
13. Digenis, George and Kortright, Kenneth H., "The Soluble Prodrugs of Paclitaxel", Filing
Date June 20, 1997.
14. Digenis, George A. and Khouri, Charles H., "Methods of Treating Eye Conditions with
Human Leukocyte Elastase (HLE) Inhibitory Agents", U.S. Patent #5,922,319. (July 13,
1999).
Reviewer of Journals or Books
Journal of Pharmaceutical Sciences 1968-present
Journal of Medicinal Chemistry 1973-present
Journal of Nuclear Medicine 1975-present
Journal of Toxicology and Environmental Health 1976-present
International Journal of Pharmaceutics 1977-78
Lloydia 1977-78
"Pro-drugs as Novel Drug Delivery Systems," by T. Higuchi and V. Stella, Editor, Am. Chem.
Soc. Steries, Washington, DC, 1975 (Review appeared in J. Pharm. Sci., 1976).
Applied Radiation and Isotopes
Pharmaceutical Research, 1989-present

32
Author of Pharmacy Books and Chapters
Digenis, G.A. and Swintosky, J.V., "Drug Latentiation," in Handbook of Experimental
Pharmacology (Concepts in Biochemical Pharmacology). Vol. 28/3, J.R. Gillette and B.B.
Brodie, editors, Springer-Verlag Berlin, New York (1975).
Digenis, G.A., A. Parr, M. Jay, "Neutron Activation Methods for Evaluation of Pharmaceutical
Dosage Forms" in Drug Delivery to the Gastrointestinal Tract, editors, J.G. Hardy, S.S. Davis
and C.G. Wilson, Ellis Horwood Press, Chichester, England, 1989, pp 111-119.
Publication External to the College of a Non-Research Nature Examples of Paper or Poster Presentations
"Polymer Assisted Synthesis of Drug Derivatives. Preparation and Reactions of Mixed
Anhydride Functions on Polystyrene," 17th National Meeting of the American Pharmaceutical
Association Academy of Pharmaceutical Sciences, New Orleans, LA, November 10-14, 1974.
"Synthesis of 18 F-Haloperidol," 17th National Meeting of the American Pharmaceutical
Association Academ
y of Pharmaceutical Sciences, New Orleans, LA, November 10-14, 1974.
"Preparation of Nitroso- 13 N Labeled Nitrosoureas," 17th National Meeting of the American
Pharmaceutical Association Academy of Pharmaceutical Sciences, New Orleans, LA,
November 10-14, 1974.
"Demonstration of the Decongestant Action of Phenylpropanolamine HCl by 133 Xe
Scintigraphy," 17th National Meeting of the American Pharmaceutical Association Academy
of Pharmaceutical Sciences, New Orleans, Louisiana, November 10-14, 1974.
"Isolation of a Bioactive Tobacco Smoke Fraction by a Chemically Activated Resin," Annual
Meeting of the Americal Pharmaceutical Association, New Orleans, LA, April 3-8, 1976.
" 13 C-NMR in Biorganic Chemistry: The Utilization of Deuterium-Carbon Splitting in the
Assignment of the Chemical Shifts of the Bisulfite Uracil Adduct," Annual Meeting of the
American Pharmaceutical Association, New Orleans, LA, April 3-8, 1976.
"Stable Alkoxyimmonium Compounds from Alcohols. Preparation, Reactions and Potential as
Pro-Drugs," Annual Meeting of the American Pharmaceutical Association, New Orleans, LA,
April 3-8, 1976.
"Study of Capsule Disintegration Time in Human Subjects by External Imaging Using a
Radionuclide," Annual Meeting of the American Pharmaceutical Association, New Orleans,
LA, April 3-8, 1976.
"Studies from Polymer Support," 21st National Meeting of the Academy of Pharmaceutical
Sciences, Orlando, FL, November 15, 1976.
"Tissue Distribution of 18 F Haloperiodal and Related Compounds by External Scintigraphy,"
21st National Meeting of the Academy of Pharmaceutical Sciences, Orlando, FL, November
15, 1976.
"The Formation of Aldehydic Functional Groups on Popcorn Polystyrene, and the Use of the
Resin as an Amine Drug Release Mechanism via the Schiff Base," 21st National Meeting of
the Academy of Pharmaceutical Sciences, Orlando, FL, November 15, l976.
"Technetium- 99m Labeled Polyamine-Polystyrene Resin as a New Radio-Diagnostic Agent for
Measuring the Rate of Gastric Emptying in Humans," 21st National Meeting of the Academy
of Pharmaceutical Sciences, Orlando, FL, November 15, l976.

"Preparation, Reactivities and Synthetic Application of Polystyrene Resins with Carbonic-
Carboxylic Anhydride Functions," 124th American Pharmaceutical Association Meeting, New
York, NY, May 18, 1977.
"Preparation of N-13BCNU and Its Tissue Distribution in Rats and Mice with Various
Tumors," 124th American Pharmaceutical Association Meeting, New York, NY, May 17, 1977.
“ 13 C-NMR Studies of Bisulfite-Pyridine Addition Reactions: Sterio- selective Formation and
Rections of Uridine, Uridine-5-Monophosphate, and the 5-Halouridine Adducts," 124th
American Pharmaceutical Association Meeting, New York, NY, May 17, 1977.
"Study of Tablet Disintegration Times in Human Subjects Using External Scintigraphy,"
124th American Pharmaceutical Association Meeting, New York, NY, May 16, 1977.
"In Vivo Disposition of 13 N-labelled Nitrosoureas and Nitrosocarbamates," Regional Cancer
Research Conference, Lexington, KY, April 19-20, 1978.
"Pharmacy Education in the Middle East," presented before the College of Pharmacy, May 4,
1978.
"Determination of pK values for the bisulfite adducts of cytidine-5'- monophosphate by 13C-
NMR," 125th American Pharmaceutical Association (APhA) Meeting, Montreal, Canada, May
13-19, 1978.
"Combination Therapy of Advanced LSA Ascites Tumors with BCNU and Chlorozotocin,"
Toronto, Canada, presented by Dr. Feola, May 14, 1978.
"The Educational Requirements for the Evolving Roles in Nuclear Pharmacy," 79th Annual
Meeting of the American Association of Colleges of Pharmacy (AACP), Orlando, FL, July 16-
20, 1978.
"Recent Advances in the Utilization of Short-Lived Radionuclides in Drug Disposition
Research," Abbott Laboratories, September 12, 1978.
"Recent Advances in the Utilization of Short-Lived Radionuclides in Drug Disposition
Research," Ohio State University, September 27, 1978.
"Recent Advances with C-Labeled Aminoacids," Department of Radiation Medicine, November
10, 1978.
"Preparation of Optically Active C-11-Amino Acids," 26th Annual Meeting of the Society of
Nuclear Medicine, Atlanta, GA, June 1979.
"A New Drug Delivery System: A Difunctionalized Styrenedivinylbenzene copolymer,"
American Pharmaceutical Association Academy of Pharmaceutical Sciences, November 12,
1979.
"Assessment of Intermittent Claudication with the Xenon-133 Clearance Technique,"
American Pharmaceutical Association Academy of Pharmaceutical Sciences in San Antonio,
Texas, November 1980.
"Mechanisms of Association of PVP-I 2 and Red Blood Cells," GAF Corporation, Wayne, New
Jersey, January 14, 1981.
"Association of Polyvinylpyrrolidone with Red Blood Cell Membranes," GAF Corporation,
Wayne, New Jersey, February 20, 1981.
"Mechanism of Action of Betadine," Purdue Frederick Company, Norwalk, CT, February 24,
1981. " 11 C-labelled Optically Active Amino Acids," Department of Radiation Medicine, U.K.
Medical Center, March 13, 1981.
33

"Tissue Distribution of D-Leucine-1- 14 C in Tumor Bearing Nude Mice," American
Pharmaceutical Association Academy of Pharmaceutical Sciences, Orlando, Florida,
November 1981.
"In Vitro Interactions of 14 C-Salicylic Acid with Albumin and Polyvinyl- pyrrolidone,"
American Pharmaceutical Association Academy of Pharmaceutical Sciences, Orlando,
Florida, November, 1981.
"Synthesis and Tissue Distribution of Novel Esters of 82 Br Bromperidol," American
Pharmaceutical Association Academy of Pharmaceutical Sciences, Orlando, Florida,
November 1981.
"Effect of Amphetamine on Brain Efflux of Phenethylamine-1- 11 C," American Pharmacetuical
Association Academy of Pharmaceutical Sciences, Orlando, Florida, November 1981.
"Synthesis of Esters of Haloperidol," American Pharmaceutical Association Academy of
Pharmaceutical Sciences, Orlando, Florida, November, 1981.
"N-Vinyl-2-Pyrrolidinone: Disposition and Metabolism Studies," 1982 Society of Toxicology
National Meeting, Boston, Massachusetts, February 23-26, 1982.
"N-Vinyl-2-Pyrrolidinone: Disposition and Metabolism Studies," American Pharmaceutical
Association Annual Meeting, Las Vegas, Nevada, April 24-29, 1982.
"Effect of Smoking on Elastolytic Activity of Rat Serum and Lung Homogenates," Academy of
Pharmaceutical Sciences 33rd National Meeting, San Diego, CA, November 14-18, 1982, p.
151.
"Effect of α-Difluoromethylornithine on Tissue Distribution of 14 C-Putrescine in Tumor
Bearing Mice," Academy of Pharmaceutical Sciences 33rd National Meeting, San Diego, CA,
November 14-18, 1982, p. 150.
"Carbonate and Carbamate Esters as Potential Substrates for the Determination of Total
Lung Proteolysis," Academy of Pharmaceutical Sciences 33rd National Meeting, San Diego,
CA, November 14-18, 1982, p. 149.
"Perturbed Angular Correlation Measurements for Assessment of Dosage Forms and Drug
Delivery," Academy of Pharmaceutical Sciences 33rd National Meeting, San Diego, CA,
November 14-18, 1982, p. 105.
"Perturbed Angular Correlation for the Study of Suppository Behavior In Vivo," Academy of
Pharmaceutical Sciences 33rd National Meeting, San Diego, CA, November 14-18, 1982, p.
106.
"Radionuclidic Method for the Determination of Critical Micellar Concentration of Ionic
Surfactants in Water," Academy of Pharmaceutical Sciences 33rd National Meeting, San
Diego, CA, November 14-18, 1982, p. 156.
"Synthesis of Some Novel HLE Inhibitors", Z. Li, B.J. Agha and G.A. Digenis, American
Association of Pharmaceutical Scientists Annual Meeting, Orlando, FL, October 30-November
6, 1988. Published in Pharm. Res. Supplement, 5, 10:S-40, October, 1988.
"Stability of Aspartame in Simulated Soft Drink Formulations", S.J. Savidge and G.A.
Digenis, American Association of Pharmaceutical Scientists Annual Meeting, Orlando, FL,
October 30-November 6, 1988. Published in Pharm. Res. Supplement, 5, 10:S-71, October,
1988.
"Polymer-bound Peptidyl Carbamates as Elstase Inhibitors", M. Grimmett, B. Agha, F.
Rypacek, B. Banks and G. Digenis, American Association of Pharmaceutical Scientists
Annual Meeting, Orlando, FL, October 30-November 6, 1988. Published in Pharm. Res.
Supplement, 5, 10:S-40, October, 1988.
34

"Pharmacokinetics of a Single Representative Oligomer of Nonoxynol-9 Following I.V.
Administration", B. Walter, B.J. Agha and G.A. Digenis, American Association of
Pharmaceutical Scientists Annual Meeting, Orlando, FL, October 30-November 6, 1988.
Published in Pharm. Res. Supplement, 5, 10:S-187, October, 1988.
"Disposition and Pharmacokinetics of Tetrafluoroputrescine in Mice", Helen Yip, Amale A.
Hawi and George A. Digenis, American Association of Pharmaceutical Scientists Annual
Meeting, Orlando, FL, October 30-November 6, 1988. Published in Pharm. Res. Supplement,
5, 10:S-185, October, 1988.
"Identification of a Major Metabolite of N-methylpyrrolidonein the Rat", D.A. Wells, A. Hawi
and G.A. Digenis, American Association of Pharmaceutical Scientists Annual Meeting,
Orlando, FL, October 30-November 6, 1988. Published in Pharm. Res. Supplement, 5, 10:S-
208, October, 1988.
"Evaluation of Sm-153 Enteric Coated Tablet in Man by External Scintigraphy", E. Sandefer,
R.M. Beihn, J. Tossounian, K. Igbal, A. W. Malick and G.A. Digenis, American Association of
Pharmaceutical Scientists Annual Meeting, Orlando, FL, October 30-November 6, 1988.
Published in Pharm. Res. Supplement, 5, 10:S-106, October, 1988.
"HPLC Separation of Nonoxynol-9 and In Vitro Spermicidal Assessment of Selected
Oligomers", B.A. Walter, B.J. Agha, P.M. Zavos and G.A. Digenis, Presented at AAPS Meeting,
Atlanta, GA, October 22-26, 1989. Published in Pharm. Res. Supplement, 6, 9:S-12,
September 1989.
"Studies on Gastric Residence Time of New Polysaccharidic Matrices in Dogs by Gamma
Scintigraphy: In Vitro - In Vivo Correlation", P. Esposito, E. Sandefer, N. Darwazeh and G.A.
Digenis, Presented at AAPS Meeting, Atlanta, GA, October 22-26, 1989. Published in Pharm.
Res. Supplement, 6, 9:S-163, September 1989.
"Evaluation of Cellulose Acetate Trimellitate (CAT) as a New Enteric Polymer by Scintigraphic
Technique, and its Effect on the Pharmacokinetis of 5-ASA", S.Z. Masih, E. Sandefer, G.A.
Digenis, R.M. Beihn, T.S. Foster, N.M. Clipse, C. Fleenor, S.H. Wu and J.C. Gilmer",
Presented at AAPS Meeting, Atlanta, GA, October 22-26, 1989. Published in Pharm. Res.
Supplement, 6, 9:S-137, September 1989.
"Study of the Formulation Factors Affecting Conclusions about the Absorption Site of an Oral
Delivery System by Scintigraphic Technique Alone", S.Z. Masih, G.A. Digenis, E. Sandefer
and R.M. Beihn, Presented at AAPS Meeting, Atlanta, GA, October 22-26, 1989. Published in
Pharm. Res. Supplement, 6, 9:S-174, September 1989.
"Evaluation of Two Artificial Tears in the Human Eye by Gamma Scintigraphy", A.A. Hawi,
T.J. Smith and G.A. Digenis, Presented at AAPS Meeting, Atlanta, GA, October 22-26, 1989.
Published in Pharm. Res. Supplement, 6, 9:S-125, September 1989.
"Erythromycin Bioavailability and Small Intestine Transit Dependency: An Evaluation by
Gamma Scintigraphy", E. Sandefer, R. Beihn, A. Parr, B. Scheinthal, I. Sellasie, U. Iyer, R.
Nesbitt and G.A. Digenis, Presented at AAPS Meeting, Atlanta, GA, October 22-26, 1989.
Published in Pharm. Res. Supplement, 6, 9:S-155, September 1989.
"High Performance Liquid Chromatographic Method for the Simultaneous Quantitation of
Acetaminophen and Riboflavin in Human Plasma:, S.L. Way, H. B. Kostenbauder and G.A.
Digenis, Presented at the AAPS Meeting, Atlanta, GA, October 22-26, 1989. Published in
Pharm. Res. Supplement, 6, 9:S-7, September 1989.
"Assessment of Site Specific Drug Delivery Using Gamma Scintigraphy", Schering Inc.,
Newark, New Jersey, November 1989.
"Positron Emission Tomography in Drug Dynamic Studies using Gamma Scintigraphy",
Schering, Inc., Newark, New Jersey, November, 1989.
35

"In Vivo Behavior of Multiparticulate and Single Dose Forms in the Gastrointestinal Tract of
Man", Tokyo, Japan, April, 1990.
"Attempts to Achieve Site Specific Delivery in the GI Tract of Man: Tanable Laboratories,
Osaka, Japan, April, 1990.
"A Quantitative Comparison of Artificial Tear Clearance Rates in Humans Using Gamma
Scintigraphy", ARVO Convention (Association for Research in Vision and Ophthalmology),
Sarasota, Florida, May 4, 1990.
"A Polymer-bound Elastase Inhibitor is Effective in Inhibiting Human Neutrophil-Elastase
Induced Emphysema", Pulmonary Emphysema: The Rationale for Therapeutic Interventions
Meeting in Orlando, Florida, May 15-18, 1990.
"Prolonging Wear of Contact Lenses Under the Influence of Protease Inhibitors (Aprotinin,
PC5) in Rabbits", J. Cejkova, G. Digenis and J. Vacik, presented at the 31st Meeting of the
Association for Eye Research, Bad Honnef/F.R.G., Germany, October 14-18, 1990.
"Novel Polymer Bound HLE Inhibitors", D. Noskova, F. Rypacek and G.A. Digenis, presented
at the Annual Meeting of the American Association of Pharmaceutical Scientists, Las Vegas,
Nevada, November 4-8, 1990. Published in Pharm. Res. Supplement, 7, 9:S-59, September
1990.
"Synthesis of 18 F-Flurbiprofen and It's Use in Dynamic Studies With Arthritic Dogs Utilizing
Positron Emission Tomography", S.T. Elder, L. Washburn, K. Dickey and G.A. Digenis,
presented at the Annual Meeting of the American Association of Pharmaceutical Scientists,
Las Vegas, Nevada, November 4-8, 1990. Published in Pharm. Res. Supplement, 7, 9:S-62,
September 1990.
"HPLC Assay of a Novel Peptidyl Carbamate Inhibitor of Elastase for Plasma Analysis", S.J.
Savidge and G.A. Digenis, presented at the Annual Meeting of the American Association of
Pharmaceutical Scientists, Las Vegas, Nevada, November 4-8, 1990. Published in Pharm.
Res. Supplement, 7, 9:S-11, September 1990.
"Synthesis and Testing of 3-Hydroxy-N-Methylpyrrolidone, A Novel Transdermal Absorption
Enhancer", W.J. Doll and G.A. Digenis, presented at the Annual Meeting of the American
Association of Pharmaceutical Scientists, Las Vegas, Nevada, November 4-8, 1990. Published
in Pharm. Res. Supplement, 7, 9:S-178, September 1990.
"Pharmacokinetics and Bioavailability of N-Vinyl-2-Pyrrolidinone in Rat and Dog", H.
Yamakita and G.A. Digenis, presented at the Annual Meeting of the American Association of
Pharmaceutical Scientists, Las Vegas, Nevada, November 4-8, 1990. Published in Pharm.
Res. Supplement, 7, 9:S-232, September 1990.
"Assessment by Scintigraphy of the Relative Importance of Size and Density on Gastric
Residence of Non Swellable Dosage Forms" P. Esposito, E. Sandefer and G.A. Digenis,
presented at the Annual Meeting of the American Association of Pharmaceutical Scientists,
Las Vegas, Nevada, November 4-8, 1990. Published in Pharm. Res. Supplement, 7, 9:S-118,
September 1990.
"Dual Isotope Imaging of Neutron Activated Erbium-171 and Samarium-153 and the In Vivo
Evaluation of a Dual-Labeled Bilayer Tablet by Gamma Scintigraphy", Erik P. Sandefer,
George A. Digenis, Robert M. Beihn and Alan F. Parr, presented at the Annual Meeting of the
American Association of Pharmaceutical Scientists, Las Vegas, Nevada, November 4-8, 1990.
Published in Pharm. Res. Supplement, 7, 9:S-198, September 1990.
"Neutron Activated Ytterbium-175 for Dual Label Scintigraphy Studies With Samarium-153:
An Alternative to Erbium-171", Erik P. Sandefer, George A. Digenis and Robert M. Beihn,
presented at the Sixth Annual Meeting of American Association of Pharmaceutical Scientists,
36

Washington, DC, November 17-21, 1991. Published in Pharm. Res. Supplement, 8, 10:S-133,
October, 1991.
"A Collagenase Inhibitor Inhibits HLE After Binding to Polymer", D. Noskova, R.E. Galardy
and G.A. Digenis, presented at the Sixth Annual Meeting of American Association of
Pharmaceutical Scientists, Washington, DC, November 17-21, 1991. Published in Pharm.
Res. Supplement, 8, 10:S-82, October, 1991.
"The Influence of Gastric Emptying on the Bioavailability of N-Vinyl Pyrrolidinone in the
Beagle", Richard C. Page, Nabil B. Darwazeh, Erik P. Sandefer, Hirokazu Yamakita and
George A. Digenis", presented at the Sixth Annual Meeting of American Association of
Pharmaceutical Scientists, Washington, DC, November 17-21, 1991. Published in Pharm.
Res. Supplement, 8, 10:S-200, October, 1991.
"Tissue Distribution and Biliary Excretion of PC1, A Peptidyl Carbamate Elastase Inhibitor",
S.J. Savidge and G.A. Digenis, Presented at the American Association of Pharmaceutical
Scientists Annual Meeting, Washington, DC, November 17-21. Published in Pharm. Res.
Supplement, 8, 10:S-263, October, 1991.
"Pharmacokinetics of a Peptidyl Carbamate Elastase Inhibitor, PC1 After Intravenous or
Intra-Arterial Administration to Rats", S.J. Savidge and G.A. Digenis, Presented at the
American Association of Pharmaceutical Scientists Annual Meeting, Washington, DC,
November 17-21, 1991. Published in Pharm. Res. Supplement, 8, 10:S-263, October, 1991.
"Characterization of Aerosol Formulations of Biodegradable Microspheres", Mahesh Kulkarni,
Vinod Philip, Walter Doll, Rahul Mehta, George Digenis and Patrick DeLuca, presented at the
Sixth Annual Meeting of American Association of Pharmaceutical Scientists, Washington,
DC, November 17-21, 1991. Published in Pharm. Res. Supplement, 8, 10:S-86, October,
1991. Published in Pharm. Res. Supplement, 8, 10:S-86, October, 1991.
"A Synthetic Leukocyte Elastase Inhibitor (PC5) Prevents Severe Alkali-Induced Changes in
Rabbit Cornea", Jitka Cejkova, George A. Digenis and Jiri Vacik, presented at the 1991
Association for Research in Vision and Ophthalmology Annual Meeting (ARVO), Sarasota, FL,
April 28 - May 3, 1991.
"The Disposition of CGP 43371, A Novel Hypolipidemic Agent, in Feces, Plasma and Urine
Following Single Oral Doses to Normal Volunteers", W.M. Maniara, M.L. Powell, A. Cipriano,
J. Sun, E. Sum, E.P. Sandefer, G.A. Digenis, Presented at the Annual Meeting of the
American Association of Pharmaceutical Scientists, San Antonio, TX, November 15-19,1992.
Published in Pharm. Res. Supplement, 9, 10:S-___, October, 1992.
"Development of a Series of Novel Nanoparticles for Use as Contrast Agents in Magnetic
Resonance Imaging", Eric Dadey and George A. Digenis, Presented at the Annual Meeting of
the American Association of Pharmaceutical Scientists, San Antonio, TX, November 15-19,
1992. Published in Pharm. Res. Supplement, 9, 10:S-68, October, 1992.
"Mechanistic Study of HLE Inhibition Using Doubly Labeled Macromolecular Inhibitor",
Fatemeh Mohammadi, Dagmar Noskova, Sandra J. Savidge, George A. Digenis, Presented at
the Annual Meeting of the American Association of Pharmaceutical Scientists, San Antonio,
TX, November 15-19,1992. Published in Pharm. Res. Supplement, 9, 10:S-101, October,
1992.
"Synthesis of Novel Aminopropylguanidine Derivatives with Potential Hypotensive Activity",
Unsal Calis, J.R. Finch, G.A. Digenis, Presented at the Annual Meeting of the American
Association of Pharmaceutical Scientists, San Antonio, TX, November 15-19, 1992. Published
in Pharm. Res. Supplement, 9, 10:S-103, October, 1992.
"Synthesis and Antihypertensive Activity of N-alkylaminopropyl Guanidines", J.R. Finch, E.
Soltis, A. Hawi, G.A. Digenis, Presented at the Annual Meeting of the American Association of
37

Pharmaceutical Scientists, San Antonio, TX, November 15-19, 1992. Published in Pharm.
Res. Supplement, 9, 10:S-104, October, 1992.
"Synthesis and Enzymatic In Vitro Study of Macromolecular Inhibitors of HLE", Fatemeh
Mohammadi and George A. Digenis, Presented at the Annual Meeting of the American
Association of Pharmaceutical Scientists, San Antonio, TX, November 15-19, 1992. Published
in Pharm. Res. Supplement, 9, 10:S-104, October, 1992.
"Effect of SAPP on Ranitidine Bioavailability and Gastrointestinal Transit Time", K.M. Koch,
A.F. Parr, J.J. Tomlinson, E.P. Sandefer, G.A. Digenis, K.H. Donn, J.R. Powell, Presented at
the Annual Meeting of the American Association of Pharmaceutical Scientists, San Antonio,
TX, November 15-19, 1992. Published in Pharm. Res. Supplement, 9, 10:S-324, October,
1993.
"Evaluation by Scintigraphy of Bioadhesive Polymers as Possible Enhancers of gastric
Residence of High Density Dosage Forms, P. Esposito, E.P. Sandefer, F. Carli and G.A.
Digenis, Presented at the Annual Meeting of the American Association of Pharmaceutical
Scientists, San Antonio, TX, November 15-19, 1992. Published in Pharm. Res. Supplement,
9, 10:S-245, October, 1992.
"In-Vivo Distribution in Rat Lung Using 111 in-labeled Poly(D,L-lactide-CO-glycoide) and
Polyglycolic Acid Microspheres", V. Philip, M. Kulkarni, W. Doll, R.C. Mehta, G. Digenis, Y.
Lai and P.P. DeLuca, Presented at the Annual Meeting of the American Association of
Pharmaceutical Scientists, San Antonio, TX, November 15-19, 1992. Published in Pharm.
Res. Supplement, 9, 10:S-251, October, 1992.
"Radiolabelled Microspheres for Evaluation of Peyer's Patch Uptake and Lung Delivery", R.C.
Mehta, B.C. Thanoo, W. Doll, L.K. Huang, H. Chadha, G.A. Digenis and P.P. DeLuca,
Presented at the Annual Meeting of the American Association of Pharmaceutical Scientists,
San Antonio, TX, November 15-19, 1992. Published in Pharm. Res. Supplement, 9, 10:S-
2524, October, 1992.
"A Scintigraphic and Pharmacokinetic Evaluation of a Novel Capsule Manufactured from
Potato Starch Compared with a Conventional Hard Gelatin Capsule in Normal and in Normal
Subjects Administered Omperazole", W.J. Doll, E.P. Sandefer, R.C. Page, N. Darwazeh and
G.A. Digenis, Presented at the Annual Meeting of the American Association of Pharmaceutical
Scientists, Orlando, FL, November 14-18, 1993. Published in Pharm. Res. Supplement, 10,
10:S-213, October, 1993.
"Absorption Enhancers for an Acid-Labile Cephalosporin With Poor Gastrointestinal
Permeability: Decreased Residence in the Small Bowel Paradoxically Improved Oral
Absorption", E.P. Sandefer, G.A. Digenis, R.M. Beihn, R.C. Page, W.J. Doll, N.B. Darwazeh,
N.H. Shah, M. Infeld, C. Patel, Presented at the Annual Meeting of the American Association
of Pharmaceutical Scientists, Orlando, FL, November 14-18, 1993. Published in Pharm. Res.
Supplement, 10, 10:S-213, October, 1993.
"The Effect of Urethane Anesthesia on the Pharmacokinetics of Compounds With Low
Extraction Ratios Using N-Vinyl-2-Pyrrolidinone (NVP) as a Model in Male Rats", R.C. Page,
N. Darwazeh, H. Yamakita, T. Suzuki and G.A. Digenis, Presented at the Annual Meeting of
the American Association of Pharmaceutical Scientists, Orlando, FL, November 14-18, 1993.
Published in Pharm. Res. Supplement, 10, 10:S-391, October, 1993.
"Distribution and Disposition of Poly-α,ß-[N(2-Hydroxyl-1-[ 3 H]-Ethyl)]-D-L-Aspartamide ([ 3 H]-
PHEA(6)NH 2 ) in the Rat After Intratracheal and Oral Administration", N. Darwazeh and G.A.
Digenis, Presented at the Annual Meeting of the American Association of Pharmaceutical
Scientists, Orlando, FL, November 14-18, 1993. Published in Pharm. Res. Supplement, 10,
10:S-408, October, 1993.
38

"Chemistry of Gelatin Cross-Linking", G.A. Digenis and T.B. Gold, Presented at the Annual
Meeting of the American Association of Pharmaceutical Scientists, San Diego, CA, November
6-10, 1994. Published in Pharm. Res. Supplement, 11, 10:S-146, October, 1994.
"Pharmacokinetics and Tissue Distribution of a Polymeric Human Leukocyte Elastase (HLE)
Inhibitor (PPC)", N.B. Darwazeh, R.C. Page and G.A. Digenis, Presented at the Annual
Meeting of the American Association of Pharmaceutical Scientists, San Diego, CA, November
6-10, 1994. Published in Pharm. Res. Supplement, 11, 10:S-407, October, 1994.
"Design, Synthesis and Evaluation of Novel Thiocarbamates as Inhibitors of Human
Leukocyte Elastase (HLE)", Nikolaos P. Rodis and George A. Digenis, Presented at the Annual
Meeting of the American Association of Pharmaceutical Scientists, San Diego, CA, November
6-10, 1994. Published in Pharm. Res. Supplement, 11, 10:S-121, October, 1994.
"The Use of Scintigraphic Imaging in the Pharmacokinetic Evaluation of the Oral Absorption
of Salmon calcitonin From a Novel Three Compartment Capsule in Beagle Dogs", W.J. Doll,
K. Takeda, E.L. Barnes, E.P. Sandefer, R. Daumesnil and G.A. Digenis, Presented at the
Annual Meeting of the American Association of Pharmaceutical Scientists, San Diego, CA,
November 6-10, 1994. Published in Pharm. Res. Supplement, 11, 10:S-300, October, 1994.
"Neutron Activation of Coat/Core Sustained Release Placebo Tablets and In Vivo Evaluation
by Dual-Label Gamma Scintigraphy", S.K. Chopra, A. Nangia, D. Lee, B.J. Fahie, A.S.
Ghutarora, V. Spate, E.P. Sandefer, R.C. Page, W.J. Doll, G.A. Digenis, Presented at the
Annual Meeting of the American Association of Pharmaceutical Scientists, San Diego, CA,
November 6-10, 1994. Published in Pharm. Res. Supplement, 11, 10:S-301, October, 1994.
"Absorption and Formulation Studies of α-2b Interferon in Beagles Following Colonic and
Subcutaneous Dosing", S.A. Sangekar, M.D. Danzitz, W.A. Vadino, I.A. Chaudry, E.P.
Sandefer, R.C. Page and G.A. Digenis, Presented at the Annual Meeting of the American
Association of Pharmaceutical Scientists, San Diego, CA, November 6-10, 1994. Published in
Pharm. Res. Supplement, 11, 10:S-301, October, 1994.
"Site Specific GI Absorption Studies for the Sustained Release Dosage (SR) Form Design of
Nilvadipine", N.R. Desai, B.J. Agha, G.A. Digenis, Presented at the Annual Meeting of the
American Association of Pharmaceutical Scientists, San Diego, CA, November 6-10, 1994.
Published in Pharm. Res. Supplement, 11, 10:S-310, October, 1994.
"Development of a Multicompartment Hard Gelatin Capsule Delivery System for Vaginal
Application and Its In Vitro and In Vivo Release Studies", F. Mohammadi, D. Noskova, N.
Darwazeh and G.A. Digenis, Presented at the Tenth Annual Meeting of American Association
of Pharmaceutical Scientists, Miami Beach, FL, November 5-9, 1995. Published in Pharm.
Res. Supplement, 12, 9:S-193, September, 1995.
"Determination of Extent of Formaldehyde-Induced Cross-Linking and Moisture Content of
Intact Hard Gelatin Capsules (HGCs) by Near-Infrared Spectrophotometry (NIR)", T.B. Gold,
R.G. Buice, Jr., R.A. Lodder, and G.A. Digenis, Presented at the Tenth Annual Meeting of
American Association of Pharmaceutical Scientists, Miami Beach, FL, November 5-9, 1995.
Published in Pharm. Res. Supplement, 12, 9:S-217&294, September, 1995.
"N-n-Butyl,1-phenyl-1H-tetrazole-5-thiocarbamate A Potent Inhibitor of Human Leukocyte
Elastase (HLE) with Potential Antiinflammatory and Antiarthritic Activity", Nikolaos Rodis
and G.A. Digenis, Presented at the Tenth Annual Meeting of American Association of
Pharmaceutical Scientists, Miami Beach, FL, November 5-9, 1995. Published in Pharm. Res.
Supplement, 12, 9:S-130, September, 1995.
"Scintigraphic Evaluation of Gastrointestinal Transit in the Yucatan Micro Swine", N.B.
Darwazeh, E.P. Sandefer, R.C. Page, S.I. Kim, K. Takeda, H. Terashima, G.A. Digenis,
Presented at the Tenth Annual Meeting of American Association of Pharmaceutical Scientists,
39

Miami Beach, FL, November 5-9, 1995. Published in Pharm. Res. Supplement, 12, 9:S-307,
September, 1995.
"Development of a Three Compartment Hard Gelatin Capsule for Oral Sustained Release
Delivery of Nifedipine", H. Anwar, D. Noskova and G.A. Digenis, Presented at the Tenth
Annual Meeting of American Association of Pharmaceutical Scientists, Miami Beach, FL,
November 5-9, 1995.
"Rhinoscintigraphy in the Assessment of Nasal Delivery Performance in Man", E. Sandefer, A.
Goldberg, W.Doll, R. Page and G.A. Digenis, Presented at the Tenth Annual Meeting of
American Association of Pharmaceutical Scientists, Miami Beach, FL, November 5-9, 1995.
Published in Pharm. Res. Supplement, 12, 9:S-288, September, 1995.
"Determination of the Disposition of a Poorly Soluble Drug After Oral Administration in
Human Subjects by γ-Scintigraphy", J.X. Sun, B. Walter, E. Sandefer, R. Page, G.A. Digenis,
A. Capriano, W. Maniara, M. Powell and K. Chan, Presented at the Tenth Annual Meeting of
American Association of Pharmaceutical Scientists, Miami Beach, FL, November 5-9, 1995.
Published in Pharm. Res. Supplement, 12, 9:S-312, September, 1995.
"The Use of Near-Infrared Imaging for Determination of Uniformity of Hydration and Extent of
Formaldehyde Induced Cross-Linking in Intact Hard Gelatin Capsules", Robert G. Buice, Jr.,
T.B. Gold, G.A. Digenis and Robert A. Lodder, Presented at the Tenth Annual Meeting of
American Association of Pharmaceutical Scientists, Miami Beach, FL, November 5-9, 1995.
Published in Pharm. Res. Supplement, 12, 9:S-36, September, 1995.
"Kinetic and Mechanism of Water Uptake by Polymers", Surinder Sethi, Anthony P. Simonelli,
Dagmar Noskova and George A. Digenis, Presented at the Tenth Annual Meeting of American
Association of Pharmaceutical Scientists, Miami Beach, FL, November 5-9, 1995. Published
in Pharm. Res. Supplement, 12, 9:S-157, September, 1995.
"Rhinoscintigraphy to Assess Bioequivalence of Nasal Products for Non-Systemically
Absorbed Drugs", Y. Chang, E.P. Sandefer, W.J. Doll, R.C. Page and G.A. Digenis, Presented
at the Annual Meeting of American Association of Pharmaceutical Scientists, Seattle, WA.,
October 27-31, 1996. Published in Pharm. Res. Supplement, 13, 9:S-175, September, 1996.
"Comparison of Gastrointestinal Transit and Absorption of Furosemide Formulated In
Controlled Release Granules", G.C. Santus, E. Robinson, C. Lazzarini, E.P. Sandefer, W.J.
Doll, R.C. Page and G.A. Digenis, Presented at the Annual Meeting of American Association of
Pharmaceutical Scientists, Seattle, WA, October 27-31, 1996. Published in Pharm. Res.
Supplement, 13, 9:S-252, September, 1996.
"In Vivo Evaluation of a Multi-Layered Tablet by Gamma Scintigraphy Following a Low Fat
and High fat Meal", P. Grenier, G. Vergnault, E.P. Sandefer, W.J. Doll, R.C. Page and G.A.
Digenis, Presented at the Annual Meeting of American Association of Pharmaceutical
Scientists, Seattle, WA, October 27-31, 1996. ublished in Pharm. Res. Supplement, 13, 9:S-
282, September, 1996.
"A Comparison of the Performance of Two Nifedipine Drug Delivery Systems (DDS) in the
Dog", H. Anwar, R.C. Page and G.A. Digenis, Presented at the Annual Meeting of American
Association of Pharmaceutical Scientists, Seattle, WA, October 27-31, 1996. Published in
Pharm. Res. Supplement, 13, 9:S-292, September, 1996.
"Scintigraphic Comparison of the Fed and Fasted State on the Delivery and GI Transit of a
Time-Release Dosage Form", J.R. Crison, P.R. Siersma, G.L. Amidon, E.P. Sandefer, W.J.
Doll, R.C. Page and G.A. Digenis, Presented at the Annual Meeting of American Association of
Pharmaceutical Scientists, Seattle, WA, October 27-31, 1996. Published in Pharm. Res.
Supplement, 13, 9:S-321, September, 1996.
40

"Evaluation of a Prototype Remote Drug Delivery Capsule (RDDC) in Healthy Adult
Volunteers for Non-Invasive Regional Drug Absorption Studies in the GI Tract of Man", A.F.
Parr, E.P. Sandefer, R. Caspar, M. McCartney, C.J. McClain, U.Y. Ryo and G.A. Digenis,
Presented at the Annual Meeting of the American Association of Pharmaceutical Scientists,
Boston, MA, November 2-7, 1997. Published in Pharm. Res. Supplement, 14, 11:S-654,
November, 1997.
"A Bioavailability Study of Leuprolide Acetate Directly Released in the Ileum and Colon of
Healthy Human Subjects Using Gamma Scintigraphy and the Intelisiter Capsule", Walter J.
Doll, Erik P. Sandefer, Richard C. Page, U. Yun Ryo, David R. Friend, Daniel L. Azarnoff,
George A. Digenis, Presented at the Annual Meeting of the American Association of
Pharmaceutical Scientists, Boston, MA, November 2-7, 1997. Published in Pharm. Res.
Supplement, 14, 11:S-654, November, 1997.
"Gastrointestinal Site Absorption Studies of a Leukotriene Antagonist in Beagles Via Gamma
Scintigraphy and Pharmacokinetics", E.P. Sandefer, K. Takeda, R.C. Page, H. Terashima and
G.A. Digenis, Presented at the Annual Meeting of the American Association of Pharmaceutical
Scientists, Boston, MA, November 2-7, 1997. Published in Pharm. Res. Supplement, 14,
11:S-655, November, 1997.
"In Vivo Evaluation of the Oral Absorption and of Transit of Avitriptan in Fed and Fasted
Sujects Using Gamma Scintigraphy", P.H. Marathe, E.P. Sandefer, G.E. Kollia, D.S. Greene,
R.H. Barbhaiya, R.A. Lipper, R.C. Page, W.J. Doll, U.Y. Ryo, G.A. Digenis, Presented at the
Fourth European Congress of Pharmaceutical Sciences, Milan, Italy, September 11-13, 1998.
Published in European Journal of Pharmaceutical Sciences, Vol 6/Suppl. 1, S65, August,
1998.
"Isolation and Identification of the Major Urinary Metabolite of N-Vinyl-2-Pyrrolidinone From
the Conscious Rat", R.C. Page, H.V. Joshi, G.A. Digenis, Presented at the Fourth European
Congress of Pharmaceutical Sciences, Milan, Italy, September 11-13, 1998. Published in
European Journal of Pharmaceutical Sciences, Vol 6/Suppl. 1, S87, August, 1998.
"Radioiodination and Pharmacokinetic Study of A Novel Insulin Derivative in Fasted Beagles",
G.A. Digenis, R.C. Page, E.P. Sandefer, H.V. Joshi, H.S. Allaudeen, Presented at the Fourth
European Congress of Pharmaceutical Sciences, Milan, Italy, September 11-13, 1998.
Published in European Journal of Pharmaceutical Sciences, Vol 6/Suppl. 1, S97, August,
1998.
"Scintigraphic and Pharmacokinetic Evaluation of the In Vivo Disposition and
Elimination of a Novel Insulin Derivative in Normal Beagles", R.C. Page, G.A. Digenis,
E.P. Sandefer, W.J. Doll, J.S. Rajagopalan, B. Radhakrishnan, N. Ekwuribe and H.S.
Allaudeen, Presented at the Annual Meeting of the American Association of
Pharmaceutical Scientists, San Francisco, CA, November 15-19, 1998. Published in
Pharm. Res. Supplement, 1, 1:S-371, November, 1998.
"Non-invasive Site Absorption Studies of an Aldosterone Antagonist (SC-66110) in
Beagles Using a Remote Control Capsule (Intelisite ® ) and Gamma Scintigraphy",
Presented at the Annual Meeting of the American Association of Pharmaceutical
Scientists, San Francisco, CA, November 15-19, 1998. Published in Pharm. Res.
Supplement, 1, 1:S-139, November, 1995. Published in Pharm. Res. Supplement, 1,
1:S-371, November, 1998.
Kinetic Study of Taxol 2 / -N-Methylpyridinium Mesylate (Taxol 2 / -MPM), A Water
Soluble Derivative of Taxol", Jaber G. Qasem, Paul M. Bummer and George A. Digenis,
Presented at the Annual Meeting of the American Association of Pharmaceutical
Scientists, San Francisco, CA, November 15-19, 1998. Published in Pharm. Res.
Supplement, 1, 1:S-262, November, 1998.
41

"Use of Clinical Gamma Scintigraphy in Fed and Fasted Human Subjects to Explain a
Double Peak Phenomenon Exhibited by a 5-HT 1 -Like Agonist", Punit H. Marathe, Erik
P. Sandefer, Georgia E. Kollia, Douglas S. Greene, Rashmi H. Barbhaiya, Robert A.
Lipper, Richard C. Page, Walter J. Doll, U.Y. Ryo, and George A. Digenis, Presented at
the Annual Meeting of the American Association of Pharmaceutical Scientists, San
Francisco, CA, November 15-19, 1998. Published in Pharm. Res. Supplement, 1, 1:S-
390, November, 1998.
"In Vitro Studies on the Mechanism and Extent of Release of Iodine From Various
Iodophors", Philip T. Fowler, N.B. Darwazeh, John D. Dell and G.A. Digenis, Presented
at the Annual Meeting of the American Association of Pharmaceutical Scientists, San
Francisco, CA, November 15-19, 1998. Published in Pharm. Res. Supplement, 1, 1:S-
531, November, 1998.
"The Use of Gamma Scintigraphy With Fast Atom Bombardment (FAB) and Mass
Spectrometry (MS) in The Study of Oral Bioavailability of Calcium Salts in Humans",
Alan F. Parr, George A. Digenis and Erik P. Sandefer, Presented at the Annual Meeting
of the American Association of Pharmaceutical Scientists, San Francisco, CA,
November 15-19, 1998. Published in Pharm. Res. Supplement, 1, 1:S-486, November,
1998.
"Gamma Scintigraphy Evaluation of the Intestinal Absorption of Stavudine in Healthy Male
Volunteers Using Intelisite® Capsule", V. Mummaneni, W. Doll, E. Sandefer, R. Page, U. Ryo,
G. Digenis, S. Kaul, Presented at the Annual Meeting of the American Association of
Pharmaceutical Scientists, New Orleans, LA, Nov. 14-18, 1999. Published in Pharm. Res.
Supplement, November, 1999.
"Evaluation of Stressed and Non-stressed Hard Gelatin Capsules Using Amoxicillin as a Drug
Marker and Gamma Scintigraphy to Confirm Time and GI Location of In Vivo Capsule
Rupture", E.P. Sandefer, G.A. Digenis, R.C. Page, W.J. Doll, T.B. Gold, N.B. Darwazeh, R.
Daumesnil, D. Cade, E.T. Cole, Presented at the Annual Meeting of the American Association
of Pharmaceutical Scientists, New Orleans, LA, Nov. 14-18, 1999. Published in Pharm. Res.
Supplement, November, 1999.
"Scintigraphic and Pharmacokinetic Evaluation of the In Vivo Disposition and Elimination of
a Novel Insulin Derivative in Normal Beagles", G.A. Digenis, e.P. Sandefer, W.J. Doll, J.S.
Rajagopalan, B. Radhakrishnan, N. Ekwuribe, and H.S. Allaudeen, Presented at the Annual
Meeting of the American Association of Pharmaceutical Scientists, New Orleans, LA, Nov. 14-
18, 1999. Published in Pharm. Res. Supplement, November, 1999.
"Novel Iodo-Nonoxynol-9 Derivatives with spermicidal and Anti-HIV Properties-Their
Synthesis and Physico-Chemical Evaluation", Philip T. Fowler and G.A. Digenis, Presented at
the Annual Meeting of the American Association of Pharmaceutical Scientists, New Orleans,
LA, Nov. 14-18, 1999. Published in Pharm. Res. Supplement, November, 1999.
"Paclitaxel 2'-N-Methylpyridinium Mesylate, A Water Soluble Drivative of Paclitaxel With Self-
Association Properties: Stability, and Conversion Studies in Plasma and in the Presence of
Interfaces", Jaber Qasem and George A. Digenis, Presented at the Annual Meeting of the
American Association of Pharmaceutical Scientists, New Orleans, LA, Nov. 14-18, 1999.
Published in Pharm. Res. Supplement, November, 1999.
“Critical Micelle Concentration of Nonoxynol-9: Alteration with Polyvinylpyrrolidone and the
Effect on Vaginal Irritation Potential”, P.T. Fowler, G.F. Doncel, G.A. Digenis, Presented at the
Annual Meeting of the American Association of Pharmaceutical Scientists, Indianapolis, IN,
Oct. 29-Nov. 2, 2000. Published in Pharm. Res. Supplement, November, 2000.
“The Role of Quantitative Lacrimal Scintigraphy in the Assessment of Ophthalmologic
Products in Normal and Disease Subjects”, G.A. Digenis, A.A. Hawi, E.P. Sandefer, D.E.
42

Cowen, Presented at the Annual Meeting of the American Association of Pharmaceutical
Scientists, Indianapolis, IN, Oct. 29-Nov. 2, 2000. Published in Pharm. Res. Supplement,
November, 2000.
43

44
Funded Grants
"Study of Factors Influencing the Nutrition of Ruminants," Smith, Kline & French Labs (with
Dean J. Swintosky) $15,300.
"In Vitro Diffusion Studies of Some Drugs Across the Chorioamnionic Membrane of Full Term
Human Placenta," University of Kentucky Research Foundation $3,611.
"Drugs on a Solid Polymer Support," Kentucky Research Foundation $4,000.
"Chemistry and Biochemistry of Gramine and Hordenine," Kentucky Research Foundation
$6,000.
"Chemistry and Biochemistry of Gramine and Hordenine," National Institute of Health
$14,248. "Undergraduate Summer Research Support (6 students)," National Science
Foundation $9,120.
"Undergraduate Summer Research Support (6 students)," National Science Foundation
$9,500.
"Drugs on a Solid Polymer Support," Kentucky Research Foundation $4,000.
"Chemistry and Biochemistry of Gramine and Hordenine," National Institute of Health
$10,459.
"Undergraduate Summer Research Support (6 students)," National Science Foundation
$9,320.
"Modification of Smoke by Chemically Active Filters," Tobacco and Health Research Institute
$23,588.
"Study of Factors Influencing the Nutrition of Ruminants," Smith, Kline & French Labs (with
Dean J. Swintosky) $5,000.
"Mechanism of Action of Antipsychotic Drugs," Smith, Kline & French Labs, $4,000.
"Chemistry and Biochemistry of Mesoridazine and Clomacran," National Institute of Health
$55,753.
"Study of Factors Influencing the Nutrition of Tuminants," Smith, Kline & French Labs (with
Dean J. Swintosky) $5,000.
"Cucurbitin and Analogs as Potential Antiparasitic Agents, University of Kentucky Research
Foundation, $1,800.
"Study of Factors Influencing Nutrition of Ruminants," Smith, Kline & French Labs (with
Dean J. Swintosky) $5,000.
"Absorption, Metabolism and Excretion of 35 S-Furosemide," Hoechst Pharmaceuticals (with
Drs. L. Dittert and J. Doluisio) $8,000.
"Modification of Smoke by Chemically Active Filters," Tobacco and Health Research Institute
$24,057.
"Biosynthetic Preparation of C-11 Labelled Adriamycin for Evaluation as a Potential Tumor
Localizing Agent," Veterans Administration (with Dr. L. Hurley) $16,600.
"Evaluation of Acute and Chronic Inhalation Toxicity of Johnsona nd Johnson Gentle (R)
Antiperspirant," Johnson and Johnson (with Dr. T. Foster) $15,000.
"Evaluation of the Decongestant Effects of Sine-Aid (R) Tablets by 133 Xe Imaging Techniques,"
Johnson and Johnson (with Dr. M. Reed) $4,900.

"Absorption and Elimination of Disodium Etidronate...," Procter & Gamble (with Dr. L.
Dittert) $18,500.
"Modification of Smoke by Chemically Active Filters," Tobacco and Health Research Institute
$27,306.
"Modification of Smoke Components by Chemically Active Filters," Tobacco and Health
Research Institute $35,570.
"Identification of Tobacco Smoke Components by Polymers," Agricultural Research Service
$25,209.
"Analysis to Determine Purity of Beta Phenethylamine," NIDA Addiction Research Center
$600.
"Research Equipment Fund," U.K. Graduate School $19,000.
"Identification of Tobacco Smoke Components by Polymers," Agricultural Research Service
$25,209.
"Modification of Smoke by Chemically Active Filters," Tobacco and Health Research Institute
$42,435.
"Synthesis of Labelled Radiopharmaceuticals," National Cancer Institute (with Drs. F.
DeLand and M. Reed) $10,750.
"Ventilation Kinetics of Paranasal Sinuses in Conjunction with Desoxyribonuclease
Treatment," Merck, Sharp and Dohme (with Drs. R. Beihn, F. DeLand, M. Reed, and G.
Zarocostas) $24,000.
"Research Equipment Fund," University of Kentucky Graduate School (with Dr. J. Triplett)
$9,000.
"Physiologic Disposition of 13 N-Nitrosoureas and Their Potential as Tumor Localizing Agents,"
National Cancer Institute, Medical Center Radiation Oncology Programm (with Drs. F.
DeLand and W. Pettit) $19,100 (renewal).
"Pharm.D. Program in Radiopharmacy," Department of Health Education and Welfare
(Special Projects Grant) $29,000 (renewal).
"Modification of Smoke by Chemically Active Filters," Tobacco and Health Research Institute
$47,506 (renewal).
"Identification of Tobacco Smoke Components by Polymers," Tobacco and Health Research
Instittue $29,038 (renewal).
"Pharm.D. Program in Radiopharmacy," National Institutes of Health (Special Project Grant)
$31,325.
"Physiologic Disposition of 13 N-Nitrosoureas and Their Potential as Tumor Localizing Agents,"
National Cancer Institute, Medical Center Radiation Oncology Program $19,100 (renewal).
"Chemically Active Filters for Modification of Smoke and Isolation of Bound Smoke
Components," Tobacco and Health Research Institute $63,499.
"FT-80 updating for CFT-20 nuclear magnetic resonance spectrometer," Graduate School,
University of Kentucky $20,000.
"Pharm.D. Program in Radiopharmacy," National Institutes of Health (Special Project Grant),
$31,325. N-Nitrosoureas and Their Potential as Tumor Localizing Agents," National Cancer
Institute, Medical Center Radiation Oncology Program $19,100 (78-79).
45

"Chemically Active Filters for Modification of Smoke and Isolation of Bound Smoke
Components," Tobacco and Health Research Institute $63,499 (78-79).
"In Vivo Disposition of 18 F-haloperidol and 82 Br-bromperidol," National Institute of Health
$38,477 (78-79).
"Synthesis of Radiopharmaceutical's with Potential in the Diagnosis and Treatment of
Cancer," National Cancer Institute $26,390 (78-79).
"In Vitro and In Vivo Disposition of 13 N-Labeled Nitrosoamines plus Nitrosocarbamates,"
Tobacco and Health $41,650 (78-79).
"In Vivo Disposition of 18 F-haloperidol and 82 Br-bromperidol," National Institute of Health,
$31,270 (79-80).
"Physiologic Disposition of 13 N-Nitrosoureas and Their Potential as Tumor Localizing Agents,"
National Cancer Institute, $26,390 (79-80).
"Disposition of 13 N-Labeled Nitrosamines and Nitrosocarbamates," University of Kentucky
Tobacco and Health Research Institute, $41,650 (79-80).
"Preparation and Disposition of 11 C- D- and L-Amino Acids," National Institutes of Health,
$48,596 (80-81).
"Chemistry and in vivo Disposition of 13 N-labeled Nitrosoamines and Nitrosocarbamates,"
Tobacco and Health Research Institute, $45,022 (80-81).
"In Vivo Disposition of 18 F-haloperidol and 82 Br-bromperidol," National Institute of Health,
$29,082 (80-81).
"Biomedical Research Development Grant," National Institutes of Health $97,300 renewal
(81-82).
"Preparation and Disposition of 11 C- D- and L-Amino Acids,." National Institutes of Health,
$50,847 renewal (81-82).
"Development of Agents for Early Detection of and Susceptibility of Emphysema in Smokers,"
Tobacco and Health, $47,602 (81-82).
"Reducing Carcinogens in Cigarette Smoke by Selective Filters," National Cancer Institute,
$48,886 (81-82).
"Development of Agents for Early Detection of and Susceptibility to Emphysema in Smokers,"
Tobacco and Health, $58,390 (82-83).
"Preparation and Disposition of 11 C- D- and L-Amino Acids”: National Institutes of Health,
$51,137 (82-83).
"Development of Methodology for Following Microcapsule Transcervical Transport in Baboon
Utilizing External Scintigraphy," Program for Applied Research Fertility Regulation, $9,950
(82' ).
"External Scintigraphy to Study Disposition of Rectal Dosage Form Matrix In Vivo," INTER/x,
Merck, Sharp and Company, $16,000 (82').
Hoffman LaRoche Equipment Fund - upgrading the Baird Atomic System 70-crystal, $14,000
(82').
Upjohn Compnay - support for a magnet for the 13 C-NMR CFT-20 instrument $28,000 (82').
Tobacco and Health, "Development of Agents for Early Detection of a Susceptibility to
Emphysema in Smokers," $58,390 (3rd year renewal).
46

National Institutes of Health, "Preparation and Disposition of 11 C- D- and L-Amino Acids,"
$51,137 (3rd year renewal).
Program for Applied Research Fertility Regulation, "Development of Methodology for
Following Microcapsule Transcervical Transport in Baboons Utilizing External Scintigraphy,"
$10,966.
Rowell Laboratories, "Cortenema Imaging Studies," $31,232 (lst year) Co- investigators: T.
Foster and M. Jay (1983).
INTERx, Merck, Sharp & Dohme Research Labs, "External Scintigraphy to Study Disposition
of Rectal Dosage Form Matrix In Vivo," $20,000 (2nd year). Co-investigator: M. Jay.
Ortho Pharmaceutical Corporation, "A Study on the Disposition of Vaginally Administered
Nonoxynol-9 in Barren and Pregnant Rats," $10,000 (1983).
"Ciba-Geigy Corporation, "External Scintigraphic Studies of Labeled Slow-K Tablets," $8,000
(1983).
"Polyamines and Suicide Inhibitors in Tumor Imaging," $178,000 (direct costs) National
Cancer Institute (1984-1987).
"Tobacco and Health Research Institute, "Design and Synthesis of Specific Human Leukocyte
Elastase Inhibitors", $55,139. (84-85).
"GI Transit Times of Two Radiolabelled Placebo Formulations", $7,000, (1984).
"Radionuclide Studies", $12,000, (G.A. Digenis and M.Jay), INTERx, Merck and Company
(1984).
"Neutron Activation Study", $15,000 (G.A. Digenis and M. Jay) $15,000, INTERx, Merck and
Company (84-85).
"Correlation of In Vitro and In Vivo Dissolution to Bioavailability by External Scintigraphy
and Perturbed Angular Correlation", $45,000, (84-86).
"Comparative Serum Concentratins of Theophylline in the Dog after Oral Administration of
111In-labelled Searle Theophylline CR-24 Preparation With and Without Food", $12,000,
Searle Research and Developement, Division of G.D. Searle and Company (1985).
"Radionuclide Studies" Interx, Merck and Company (continued), $20,025 (with Dr. M. Jay),
(85-86).
"Kinetics and Mechanism of Degradation of Aspartame", $25,000, Searle Research and
Development (Searle Food Resources) (with Dr. A. Hussain) (1986).
"Correlation of the GI Behavior of Erythromycin Beads to the Bioavailability of the Drugs",
pending, (b) "Disposition of Calcium Carbonate After Oral Administration in Man", Warner-
Lambert Co. $25,000 (1986)
"(a)"Synthesis of C-Alprazolam", pending; (b)"Synthesis and Preliminary Disposition studies
with 19 F-Flurbiprofen", The Upjohn Company, $110,000 (1986).
"Assessment of a Bioadhesive Coating on the GI Transit Time of Pellets in Humans", $75,000
(1986), "Purchase of Gamma Camera", $25,000, Eli Lilly, Company (1986).
"Novel Elastase Inhibitors: Mechanism and In Vivo Studies, $331,988 (3 years) National
Institute of Health, Pending (1986).
"Clinical Evaluation of Polymeric Dosage Forms of 5ASA", Eastman Kodak Company,
$70,000 (with Dr. T. Foster) December, 1986 - June, 1988.
"Studies on Polymerbound Peptidyl Carbamates", $43,500, Tobacco and Health Research
Institute, July, 1987 - June 1988.
47

"Development of Novel Scintigraphy Techniques: Monitoring In Vivo Behavior with Gastric
Retention Properties", $19,200, July, 1987 - June 1988.
"Graduate Student Stipend: Novel Chemical Entities for Colonic Delivery", $11,000, Eli Lilly
Company, December, 1987 - December, 1988.
"Evaluation of Samarium 153 Labeled Enteric Coated Tablets in Man by External
Scintigraphy", Hoffman-LaRoche Company, $18,000, December, 1987 - December, 1988.
"Studies on Precorneal Retention of Multiparticulate Formulation by Gamma Scinti-graphy",
Allergan Pharmaceutical Company, $83,000, December, 1987 - December, 1988.
"Evaluation of Nivaldipine Oral Dosage Form in Dogs by External Scintigraphy", American
Cyanamide Company, $14,030, January, 1988 - January, 1989.
"Cefuroxime Bioavailability Studies", Glaxo Company, $8,337, January, 1988 - December
1989.
"Studies on Polymer-Bound Peptidyl Carbamates as an Elastase Inhibitor", 7/1/88-6/30/89,
Tobacco and Health Institute, $45,000 (2nd year).
"Studies on Polymer-bound Peptidyl Carbamates as Elastase Inhibitors", PI-G.A. Digenis,
Tobacco & Health Research Institute, 7/1/89-6/30-90 $45,698 (3rd year).
"An Evaluation of the Effects of Food Tablet Size and Tablet Density on Gastric Residence
and Small Bowel Transit Time of Placebo Tablets", Burroughs Wellcome Company, PI-G.A.
Digenis, November 1, 1989 - October 31, 1990, $64,975.
"Studies on the in vitro and in vivo Uptake of Polymeric Nanoparticles by Macrophages",
Eastman (Sterling) Pharmaceutical Company, PI-G.A. Digenis, March 15, 1989 - February 1,
1990, $65,000.
"Disposition of Human and Bovine Growth Hormone from a Sustained Release Formulation
in the Dog", Eli Lilly Company, PI-G.A. Digenis, July 1, 1989 - June 30, 1990, $5,235.
"Evaluation of Bovine Growth Hormone Using Gamma Scintigraphy in the Sheep", Eli Lilly
and Company, PI-G.A. Digenis, July 1, 1989 - June 30, 1991, $65,000.
"Alprazolam Studies", Upjohn Company, PI-G.A. Digenis, February 9, 1989 - December 9,
1989, $27,773.
"Pre-corneal Retention of Artificial Tears", Allergan Pharmaceuticals, PI-G.A. Digenis,
January 1, 1989 - June 30, 1989, $30,000.
"Effect of Formulation on Ranitidine Absorption", Glaxo, Inc. PI-G.A. Digenis, September 1,
1989 - July 31, 1990, $42,960.
"Disposition of N-vinylpyrrolidone After Oral Administration in the Rat", GAF Corporation, PI-
G.A. Digenis, August 1, 1989 - July 31, 1991, $50,000.
"An Evaluation of Ranitidine Bioavailability from Sustained Release Formulation in Healthy
Adults", Glaxo, Inc., PI-G.A. Digenis, March 1, 1990 - February 28, 1991, $30,000.
"Bioavailability of Nicergoline from a Transdermal Patch in Man", P.I.-G.A. Digenis, April 1,
1990 - March 31, 1991, Vectorpharma, $65,000.
"The Disposition of CGP 43371 Following an 800mg Oral Dose to Healthy Males", P.I. G.A.
Digenis, April 15, 1991 - August 14, 1992, Ciba Geigy Company, $82,349.
"Studies on Metabolism", P. I. G.A. Digenis, April 15, 1991 - April 14, 1992, 3M
Pharmaceuticals, $5,000.
"An Evaluation of Ranitidine Bioavailability from Sustained Release Formulation in Healthy
Adults", Glaxo, Inc., P.I.-G.A. Digenis, August 1, 1991 - August 1, 1993, $49,000.
48

"Lipid Nanospheres for Lymphatic Absorption", Vectorpharma, September, 1991-September
1993, $45,000.
"Studies on the Metabolism and Dispostiion of Tetrafluroethane (R-134A) Utilizing Nuclear
Magnetic Resonance (NMR) and Positron Emission Tomography (PET)" International
Pharmaceutical Aerosol Consortium (IPACT-I), January 15, 1992 - January 14, 1993, (Pilot
Study $5,000) + $126,205.
Sustained Release Formulations of Guan Gum" CIBUS Pharmaceuticals, Inc., P.I. G.A.
Digenis, $37,770, 2-19-93.
"Evaluation of I-125 Interferon Formulations in Beagles", Schering, $37,563, 1-1-93.
"A Scintigraphic and Pharmacokinetic Study of the Rowasa 500 mg Mesalamine Tablet in
Healthy Human Subjects, Solvay Pharmaceuticals, P.I. G.A. Digenis, $36,907.
"An Evaluation of Nasal Spray Deposition and Clearance by Gamma Scintigraphy", P.I. G.A.
Digenis, $5,000.
"An Evaluation of Ranitidine Bioavailability from Sustained Release Formulation in Healthy
Adults", Glaxo Canada, Inc., P.I. G.A. Digenis, $30,000 (continuation), 8-1-91/8-1-93.
"Evaluation of an Oral Remoted Control Capsule in Humans", Glaxo, Inc., P.I. G.A. Digenis,
$25,000.
"A Pharmacokinetic and Scintigraphic Comparison of a New Starch Capsule and Hard
Gelatin Capsule - Potential Uses for Drug Delivery to Achloehydric Patients", Warner-
Lambert, $5,000, 3-1-92/12-31-92.
"Neutron Activation of Samarium-153 and Ytterbium-175 for Dual Labeled in vivo Evaluation
of Pharmaceutical Dosage Forms by gamma-scintigraphy", Glaxo-Canada, $13,854, 3-1-92.
"Biodistribution of 2H-Heptafluoropropane (HFA-227) Using 19 F Magnetic Resonance
Spectroscopy", International Pharmaceutical Aerosol Consortium (IPACT-II), November, 1992.
"Evaluation of I-125 Interferon Formulations in Beagles", Schering-Plough, P.I. G.A.Digenis,
$37,563, 1-1-93/11-30-93.
"Sustained Release Formulations of Guan Gum", CIBUS Pharmaceuticals, Inc., $23,406, 2-
19-93.
"Development and Testing of Novel Formulations of PVP-I/N-9 Coprecipitates as Possible
Vaginal Contraceptives with Anti-HIV Properties", NIH, $1,182,108/3 years, 4-1-93/3-31-
96. (extended through June 30, 1996).
"A Pharmacokinetic and Scintigraphic Evaluation of Ranitidine Guar Gum Formulations in
Healthy Human Volunteers", CIBUS Pharmaceutical, Inc., (extension) $5,088, 2-4-93/2-4-
94.
"The Development and In Vivo Assessment of a Gastric Retentive Delivery Device for the
Sustained Delivery of Captopril in Beagles", JAGO Pharma AG, $22,749, 1-01-94/1-31-96.
"Pre-Clinical In Vitro Development and Testing of a New Guar Gum Based Aspirin Tablet
Formulation, CIBUS, $22,724, 3-1-94/2/28-97.
"Effect of Amylin Agonists and Antagonists on Gastric Emptying", Glaxo, Inc., (USA),
$28,350, 8-1-94/8-18-96.
"Gastrointestinal Site Absorption Studies of ONO-4057 in Beagle Dogs via External Gamma
Scintigraphy and Pharmacokinetics", ONO Pharmaceuticals, Inc., $22,680, 8-18-94/7-31-96.
"Evaluation of the Feasibility of Activating a Remote Control Drug Delivery Device in Healthy
Adult Volunteers, Glaxo, Inc., $39,882, 8-1-94/7-31-96.
49

"An evaluation of GI transit and bioavailability of ranitidine from a sustained release
formualtion in fasted and fed healthy adult volunteers", Glaxo Canada, Continuation service
contract for $14,238 for a total of $101,725.
"Development and testing of guar gum formulations in beagle dogs", Cibus Pharmaceutical,
$74,031, 3-1-94/02-28-97; $16,773 through April 28, 1997.
"Ranitidine/guar gum formulations. II. A pharmacokinetic and scintigraphic evaluation in
healthy human volunteers", Cibus Pharmaceutical, Continuation service contract for $5,088
for a total of $47,839, 1/14/94.
"Bioavailability of amoxicillin from stressed and non-stressed hard gelatin capsules and in
vivo assessment of capsule rupture by gamma scintigraphy", Warner-Lambert/Capsugel,
$48,913, 9-13-94/9-12-96.
"Evaluation of gastrointestinal drug absorption in mini-pigs via aromatic azo cross-linked
polymer coated formulation and gamma scintigraphy", ONO Pharmaceutical, Inc., $3,723,
12-01-94/11-30-96.
"A pharmacokinetic and scintigraphic evaluation of ranitidne guar gum formulations in
healthy human volunteers", Cibus Pharmaceutical Inc., $37,226, 2-23-95/03-11-96.
"In vivo evaluation of a multi-layered oral tablet by gamma scintigraphy using single or dual
labeling methods and neutron activated Samarium-153 and Ytterbium-175", JAGO/P.G.,
$43,716, 4-1-95/3-31-96.
"In vitro diffusion of iodine from Duraprep", 3M Company, $9,765, 07-01-95/12-31-95.
"An evaluation of nasal spray deposition and clearance", Bausch & Lomb, $12,512., 08-28-
95/12-31-95.
"F-19 (NMR) analysis of trifluoroacetic acid (TFA) in human urine samples", 3M Company
(Harrison), $10,458, 9-1-95/12-31-95.
"External Scintigraphy and Pharmacokinetic Studies on Oral Formulations of Drugs which
Show Discontinuous Absorption in the Gastrointestinal Tract", Recordati, $26,057, 8-31-
96/9-25-96.
"In vivo scintigraphic evaluation of a pulsatile delivery system", TSRL, $25,865, 8-21-95/08-
20-96.
"An evaluation of nasal spray deposition and clearance, Part II: Glunisolide Nasal Solutions",
Bausch & Lomb, $9,362, 10-18-95/12-31-95.
"In Vivo Evaluation of the absorption and GI transit of BMS-180048 in the fed and fasted
subjects using gamma scintigraphy", Bristol-Meyers, $42,172, 11-20-95/02-29-96.
"An evaluation of nasal spray deposition and clearance part III: Desmopressin acetate nasal
solutions", Bausch & Lomb, $9,362, 12-01-95/01-31-96.
"Gamma Scintigraphic Determination in Beagles of In Vivo disintegration and dispersal of
oral dosage form containing bile salt sequestering agents, DuPont Merck, $40,320, 2-1-
96/1-31-97.
"Pilot Synthesis of 2'-MPA", Baker Norton Pharmaceuticals, $55,440, 3-1/96/2-28-97.
"A Bioavailability Study of Leuprolide Acetate Directly Relased in the Ileum and Colon of
Healthy, Young Subjects by a Remote Controlled Delivery Device", Cibus, $9,450, 07-20-
96/07-19-97.
"Site Absorption studies of SC-66110 in Beagles Using a Remote Controlled Capsule and
Gamma Scintigraphy", G.D. Searle & Co, $26,430, 12-15-96/12-14-97.
50

"Evaluation of Ins-hexyl Mixture in Normal Beagles by Gamma Scintigraphy and
Pharmacokinetics, Scintipharma, $22,680, 6-1-97/5-31-98.
"(Extended) Development and Testing of Novel Formualtions of PVP-I/N-9 Coprecipitates as
New Vaginal Contraceptive with Anti-HIV Properties, $1,283,371, (ends 11/30/97).
"Development and Testing of Novel Formulations of PVP-I/N-9 Coprecipitates as Possible
Vaginal Contraceptives with Anti-HIV Properties", NIH, extended to 10/29/99, $12,786.90
(2-1-98/4-30-98) and $63,425.00 (11-1-98/11-1-99).
"Evaluation of Ins-hexyl Mixture in Normal Beagles by Gamma Scintigraphy and
Pharmacokinetcs", Scintipharma, Inc., $67,680.00, extended 12-31-99.
"Development of Scintigraphic Techniques and Preliminary Human Studies to Non-invasively
Evaluate the In Vivo Disposition of Vaginal products in Healthy Human Volunteers: A Pilot
Study" (Pilot #1), CONRAD, $24,967, 3-1-98/8-31-98.
"Development of a Novel Spermicidal Compound and its Preliminary Evaluation as a Possible
Drug Candidate: A Pilot Study" (Pilot #2), CONRAD, 9-1-98/4-30/99, $35,142.00.
"Development of Scintigraphic Techniques and Preliminary Human Studies to Non-invasively
Evaluate the In Vivo Disposition of Vaginal Products in Healthy Human Volunteers",
CONRAD, $172,776, 8-1-99/7-31-00.
"Evaluation of Ins-hexyl Mixture in Normal Beagles by Gamma Scintigraphy and
Pharmacokinetcs", Scintipharma, Inc., $30,000, extended 12-31-00.
"Preliminary Canine Vaginal Radiotracer Studies to Validate Methodology for Subsequent
Human Clinical Studies: A Pilot Study", FDA, $25,000, 9-30-99/9-29-00.
“Vaginal Imaging Study of Replens® and K-Y® Using Three Imaging Techniques, CONRAD*,
$128,690, 9-1-01/8-31-02.
51
*Contraceptive Research and Development Program

52
Ph.D.-Graduated Under Dr. G.A. Digenis
Name Ph.D. Theses Title Yr/Graduation
1. Valentine Mihranian "The Riboflavin Catalyzed Anaerobic Photo-
Decomposition of 9-Amino-methylacridan" 1973
2. Shukri R. Shakhshir "Studies on the Release of Covalently Bound
Carboxylic Acid from Polymer Support and
Anaerobic Photodecomposition of an Acridan
Drug Through Energy Transfer" 1975
3. Chyung S. Kook "Synthesis and In Vivo Distribution Studies of
[ 18 F] Haloperidol and Its Major Metabolite 1975
4. Michael Theodorakis "Preparation and Evaluation of A Polystyrene Resin
as a Technetium 99m Carrier: A New Radiodiagnostic
Agent for Gastric Emptying Time in Humans" 1975
5. Gary E. Martin "Studies on the Preparation, Stability and Reactivity
of Polystyrene Mixed Carbonic-Carboxylic Anhydrides" 1976
6. John W. Triplett "Carbon-13 NMR Studies of the Reactions of Bisulfite
with Biologically Important Pyrimidines and Halogenated
Pyrimidines" 1977
7. Dennis L. Casey "Studies on the Preparation, Resolution and Tissue
Distribution of Carbon-11 Labelled Amino Acids" 1978
8. Roy L. McQuinn "The Disposition of Nitrogen-13 Labeled Nitrosoureas
in the Rat and Combined Modality Chemotherapy" 1978
9. Styliani H. Vincent "Synthesis of Bromine-82 Bromperidol and Preliminary
Investigation of its In Vivo Disposition in Rats 1979
10. Ying-Chi Cheng "The In Vivo and In Vitro Disposition of Nitrogen-13
Labeled Nitrosocarbamates" 1980
11. Michael Jay "Synthesis of Carbon-11 Labelled Phenethylamine
and Measurement of its In Vivo Uptake in Dog Brain" 1980
12. Mary Faye Smith "The Synthesis and Tissue Distribution Studies of
Two Novel Esters of Haloperidol, and the Application
of Radiolabelling Techniques Using Short-Lived
Radionuclides in the Study of the Disposition
Characteristics of Suspended Aerosol Particles" 1982
13. Michael G. Fakes "Synthesis and In Vitro Studies of Bromperiod Esters
with Prodrug Potential" 1983
14. Munir Hussain "Development of Methodology for Preparation of
11C-Labeled Phenethylamine-type Compounds and Studies

on the Effect of Amphetamine on Brain Efflux of Radiolabeled
Phenethylamine" 1983
15. Judy McClanahan "Synthesis and In Vivo Disposition of N-Vinyl-2-Pyrrolidinone” 1984
16. Munir Nassar "Effects of Structural Variations on the Rates of Enzymatic
and Non-Enzymatic Hydrolysis of Carbonates and
Carbamates" 1984
17. Abdul Kareem Abdul "Peptidyl Carbamates Incorporating Amino Acid Isosteres
as Novel Elastase Inhibitors: Modification of P 1 and P 1
Residues 1986
18. George A. Garbolas "Design and Synthesis of Novel Carbamate Esters
Incorporating Arginine or Lysine Isosteres as Potential
Inhibitors of Acrosin 1986
19. Alan F. Parr "Radiolabeling of Intact Dosage Forms by Neutron Activation
for In Vivo Scintigraphic Studies 1986
20. Ralph Bouvette “Studies on the in vitro and in vivo Hydrolysis and
Intramolecular Aminolysis of L-Aspartyl-L-Phenylalanine
Methyl Ester" 1986
21. David A. Wells "N-Methyl-2-Pyrrolidinone: Radiochemical Synthesis, In Vivo
Disposition and Metabolism in the rat" 1986
22. William F. Rencher, Jr. "Design and Synthesis of Desmosine-like Peptidyl Carbamates
as Novel Inhibitors of Human Leukocyte Elastase" 1988
23. Brian A. Walter "Nonoxynol-9: In Vivo Disposition, Metabolism and In Vitro
Spermicidal Assessment of Selected Oligomers" 1988
24. Helen Yip "Studies on Some Fluorinated Polyamines as Potential
Tumor Imaging Agents" 1988
25. William R. Banks "Development of a Metabolically Stable Tracer for In Vivo
Studies of the Benzodiazepine Receptor: 11 C-Alprazolam" 1990
26. S. Todd Elder "Synthesis and In Vivo Distribution of A Non-steroidal
Antiinflammatory Drug: 18 F-Flurbiprofen" 1991
27. Sandra J. Savidge "Studies on the In Vitro Stability, In Vivo Disposition and
Pharmacokinetics of PC1, A Novel Elastase Inhibitor" 1991
28. Zhanyi Sky Li-Pan "Synthesis of Novel Peptidyl Carbamate Elastase Inhibitors
and In Vivo Assessment of Their Potency" 1991
29. Walter J. Doll "3-Hydroxy-N-Methyl-2-Pyrrolidinone: Synthesis, in vitro,
and In Vivo Evaluation as a Novel Transdermal Absorption
Enhancer" 1991
53

54
30. Eric J. Dadey "Development of A Series of Novel Nanoparticles With
Applications in Drug Delivery and Magnetic Resonance
Imaging" 1992
31. Fatemeh Mohammadi "A Novel Macromolecular Inhibitor of Human Leukocyte
Elastase (HLE): In Vitro Enzymatic Evaluation, and
Mechanistic Study of its HLE Inhibition" 1993
32. John R. Finch "In Vivo 19 F Magnetic Resonance Spectroscopy (MRS), 18 F
Synthesis, and In Vivo Positron Emission Tomography (PET)
Studies of an Ozone-Gentle Aerosol and Refrigerant:
1,1,1,2-Tetrafluoroethane(HFC-134a)" 1994
33. Nikolaos P. Rodis "Novel Low Molecular Weight Thiocarbamates as Inhibitors
of Human Leukocyte Elastase (HLE) With Potential Anti-
Inflammatory Activity" 1995
34. Nabil B. Darwazeh "Synthetic Macromolecular Inhibitor of Human Leukocyte Elastase:
In vivo Disposition Studies Following Intravenous
and Intratracheal Administrations to the Rat" 1995
35. Erik P. Sandefer "Contributions of Gamma Scintigraphy to the In Vivo Evaluation
of Oral Dosage Forms: Implications of Gastrointestinal Transit
Times and the Effect on Drug Absorption" 1996
36. Hanan S. Anwar "Development of a Three Compartment Oral Sustained
Release Delivery System for Nifedipine: an In Vitro and
In Vivo Comparison with an Osmotic Pump Delivery System,
in the Dog" 1997
37. Richard C. Page "Investigation of the In Vivo Clearance of an Exocyclic Vinyl
LactamCompound, N-Vinyl-2-Pyrrolidinone, in the Conscious
Rat and Dog" 1997
38. T. Bradley Gold "Studies on the Chemistry of Cross-Linking of Gelatin
Capsules" 1998
39. Jaber V. Qasem "Synthesis and Development of a Water Soluble Derivative of
Paclitaxel (Taxol)" 1999