George A. Digenis, Ph.D. - University of Kentucky - College of ...

141. Stone, Phillip J., Lucey, Edgar C., Noskova, Dagmar, Digenis, George A. and Snider,
Gordon L., "Covalently Linking a Peptidyl Carbamate Elastase Inhibitor to a Hydrophilic
Polymer Increases Its Effectiveness in Preventing Emphysema and Secretory Cell
Metaplasia in the Hamster", Am. Rev. Respir. Dis., 146:457-461 (1992).
142. Digenis, G.A. and Rodis, N., "Drug Design: From Bench to the Market Place",
Pharmakeftiki, 5, 145-154 (1992),
143. Digenis, George A., McClanahan, J.S., and Chen, Pei-Lin, "Synthesis of [2,3,4,5- 14 C]-1-
Vinyl-2-Pyrrolidinone", Journal of Labelled Compounds and Radiopharmaceutials, Vol.
XXXIII, No. 1, 11-17, (1993).
144. Banks, William R., Clore, L. Stanton, Dadey, Eric J., Digenis, George A., "Tritiated and
Deuterated Alprazolam. The Use of Deuterium NMR to Study Isotope Exchange in
Tritiated Alprazolam", Appl. Radiat. Isot. Vol. 44, No. 7, pp. 1021-1027, (1993).
145. Kato, Masayuki, Agha, Bushra J., Abdul-Raheem, Abdul-K., Tsuji, Kiyoshi, Banks,
William R., and Digenis, George A., "Peptidyl Carbamates as Novel Elastase Inhibitors:
Structure-Activity Relationship Studies", J. of Enzyme Inhibition, Vol 7, pp. 105-130,
(1993).
146. Digenis, George A., Banks, William R., Kato, Masasuki, Rencher, William F., and Agha,
Bushra J., "Peptidyl Carbamates as Human Leukocyte Elastase Inhibitors: Design and
Synthesis of Desmosine-Like Tetrapeptidyl Carbamate Inhibitors", J. Enzyme Inhibition,
Vol. 7, pp 275-301, (1993).
147. Noskova, Dagmar, Mohammadi, Fatemeh, Savidge, Sandra J., Digenis, George A.,
"Mechanistic Study of HLE Inhibition Using Dual Labeled Macromolecular Inhibitor", J.
Enzyme Inhibition, Vol. 7, pp 303-309, (1993).
148. Koch, Kevin M., Parr, Alan F., Tomlinson, Julie J., Sandefer, Erik P., Digenis, George A.,
Donn, Karl H., and Powell, J. Robert, "Effect of Sodium Acid Pyrophosphate on
Ranitidine Bioavailability and Gastrointestinal Transit Time", Pharm. Res., 10:1027-
1030, (1993).
149. Rypacek, Frantisek, Banks, William R., Noskova, Dagmar, and Digenis, George A.,
"Synthetic Macromolecular Inhibitors of Human Leukocyte Elastase. 1. Synthesis of
Peptidyl Carbamates Bound to Water-Soluble Polymers: Poly-α,ß-[N-(2-hydroxyethyl)-
D,L-aspartamide] and Poly-α-[N 5 -(2-hydroxyethyl)-L-glutamine]", J. Medicinal
Chemistry, 37, pp 1850-1856 (1994).
150. Digenis, George A., Gold, Thomas B., Shah, Vinod P., "Cross-Linking of Gelatin
Capsules and Its Relevance to Their In Vitro-In Vivo Performance", J. Pharm. Sciences,
83, 7:915-921 (1994).
151. Calis, Unsal, Finch, John R., Soltis, Edward E., Digenis, George A., "Synthesis of Novel
Aminopropyl-guanidine Derivatives with Potential Antihypertensive Activity", Pharm.
Res., 11, 8:1211-1215 (1994).
152. Buice, Robert G., Jr., Gold, Thomas B., Lodder, Robert A., Digenis, George A.,
"Determination of Moisture in Intact Gelatin Capsules by Near-Infrared
Spectrophotometry", Pharm. Res., 12, 1:161-163, 1995.
153. Finch, John R., Dadey, Eric J., Smith, Sanford L., Harrison, Lester I., Digenis, George
A., "Dynamic Monitoring of Total-Body Absorption by 19 F NMR Spectroscopy: One Hour
Ventilation of HFA-134a in Male and Female Rats", Magnetic Res. in Med., 409-413,
1995.
154. Dobbs, Frank R., Banks, William, Fleishaker, Joseph C., Valentine, Alan D., Kinsey,
Berma M., Franceschini, Mark P., Digenis, George A., Tweson, Timothy J., "Studies with
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