A Clinical Comparison of Technegas and Xenon-133 in 50 Patients ...
A Clinical Comparison of Technegas and Xenon-133 in 50 Patients ...
A Clinical Comparison of Technegas and Xenon-133 in 50 Patients ...
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FiCURE 3. Posterior projection with xenon- <strong>133</strong> (top left), <strong>Technegas</strong><br />
(upper right), <strong>and</strong> macroaggregated album<strong>in</strong> (middle left) perfusion<br />
<strong>and</strong> right posterior oblique projections with <strong>Technegas</strong> (lower right)<br />
<strong>and</strong> macroaggregated album<strong>in</strong> (bottom left) perfusion from 76-yearold<br />
woman with acute onset <strong>of</strong> dyspnea, pleuritic chest pa<strong>in</strong>, <strong>and</strong><br />
syncope. Right posterior oblique views assisted level <strong>of</strong> confidence<br />
<strong>in</strong> diagnosis <strong>of</strong> pulmonary embolism.<br />
quality It has dist<strong>in</strong>ct advantages over xenon-<strong>133</strong>. In<br />
<strong>in</strong>dependent trials, the transport <strong>of</strong><strong>Technegas</strong> through<br />
the lungs is <strong>in</strong>dist<strong>in</strong>ct from gaseous agents, <strong>and</strong> therefore<br />
although particulate <strong>in</strong> nature, <strong>Technegas</strong> may be<br />
compared to gaseous agents. The capacity to obta<strong>in</strong><br />
multiple views directly comparable with the perfusion<br />
study with excellent compliance <strong>and</strong> acceptance by<br />
patients are the pr<strong>in</strong>cipal advantages. High-quality<br />
diagnostic images can be rout<strong>in</strong>ely obta<strong>in</strong>ed with very<br />
little effort <strong>in</strong> even very ill patients. The equipment is<br />
compact <strong>and</strong> mobile.<br />
The ability to perform dynamic <strong>and</strong> tomographic<br />
studies <strong>of</strong> directly comparable ventilation <strong>and</strong> perfusion<br />
images may well open an important new role for<br />
computerized analysis.<br />
<strong>Technegas</strong> allows high-quality ventilation imag<strong>in</strong>g.<br />
Its ease <strong>of</strong> use makes <strong>Technegas</strong> an ideal agent <strong>in</strong> busy<br />
cl<strong>in</strong>ical nuclear medic<strong>in</strong>e departments, <strong>and</strong> its method<br />
<strong>of</strong> production may open up a whole new range <strong>of</strong><br />
technetium radiopharmaceuticals.<br />
ACKNOWLEDGMENTS: To all the patients who so will<strong>in</strong>gly<br />
agreed to the formal requirements <strong>of</strong> the trial <strong>and</strong> made the work<br />
possible; to the technicall, nurs<strong>in</strong>g, <strong>and</strong> clerical staff who cheerfully<br />
took on the extra duties dem<strong>and</strong>ed by the trial protocol; <strong>and</strong> to<br />
Arnersham (Australia) who provided the xenon-<strong>133</strong> <strong>and</strong> disposable<br />
breath<strong>in</strong>g units, ouir s<strong>in</strong>cere thanks.<br />
CHEST 94 / 2 f AUGUST, 1988 303<br />
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