atrial fibrillation and stroke prevention - Continuing Medical ...
atrial fibrillation and stroke prevention - Continuing Medical ...
atrial fibrillation and stroke prevention - Continuing Medical ...
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Essentials in Primary Care Conference<br />
Wednesday, July 31, 2013<br />
Warfarin<br />
first used<br />
Timeline of Antithrombotic<br />
Therapies for Atrial Fibrillation<br />
Unfractionated heparin<br />
for PE<br />
Efficacy of warfarin<br />
to prevent AF-related <strong>stroke</strong><br />
demonstrated<br />
Fondaparinux, bivalirudin<br />
<strong>and</strong> argatroban<br />
approved<br />
LMWHs approved<br />
For VTE<br />
FDA rejects ximelagatran:<br />
possible liver toxicity<br />
FDA approves<br />
dabigatran<br />
Dabigatran <strong>and</strong><br />
rivaroxaban<br />
Europe <strong>and</strong> Canada<br />
FDA approves<br />
rivaroxaban<br />
FDA<br />
approves<br />
apixaban<br />
1950’s<br />
1960<br />
Early<br />
1990’s<br />
Mid-<br />
1990’s<br />
2000-1<br />
2004<br />
2009 Oct 2010<br />
Nov 2011<br />
Dec 2012<br />
XII<br />
Unfractionated<br />
Heparin<br />
XI<br />
IX<br />
Low<br />
Molecular<br />
Weight<br />
Heparin<br />
VIII<br />
X<br />
V<br />
II<br />
I<br />
Fibrin Clot<br />
Ericksson BI et al. Clinical Pharmacokinetics 2009;48:1-22<br />
Anticoagulants<br />
FDA Approved* <strong>and</strong> In Development**<br />
VII<br />
New Oral Xa<br />
Inhibitors<br />
Rivaroxaban*<br />
Apixaban*<br />
Edoxaban**<br />
Warfarin<br />
New Oral IIa<br />
(Direct<br />
Thrombin)<br />
Inhibitor<br />
Dabigatran *<br />
Jan Basile, MD<br />
Atrial Fibrillation & Stroke Prevention
Change language