atrial fibrillation and stroke prevention - Continuing Medical ...

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Essentials in Primary Care Conference Wednesday, July 31, 2013 Dabigatran Dosing • Dosing with normal renal function 150mg PO b.i.d with or without food. swallow capsules whole • Renal impairment: • CrCL 15-30 mL/min : 75mg b.i.d. • CrCL 30 Start parenteral anticoagulant 12 hrs after the last dose of dabigatran < 30 Start parenteral anticoagulant 24 hours after the last dose of dabigatran Dabigatran Package Insert Jan Basile, MD Atrial Fibrillation & Stroke Prevention
Essentials in Primary Care Conference Wednesday, July 31, 2013 Time to Stroke or Systemic Embolism: Dabigatran vs. warfarin, stratified by center-based time-in-range (TTR) Wallentin et al. Lancet 2010. 376:975-83 Differences in Major Outcomes in RE-LY and RELY-ABLE RE-LY patients (n=18,113) Dabigatran Dabigatran HR p-value 150 mg bid 110 mg bid stroke (/yr) 1.0% 1.4% 0.70 (0.56–0.89) 0.003 major bleeding (/yr) 3.1 % 2.7 % 1.16 (1.00-1.34) 0.05 RELY-ABLE patients (N=5,671 stroke (/yr) 1.2 % 1.4 % 0.89 (0.66-1.21) n.a. major bleeding (/yr) 3.8 % 3.0 % 1.26 (1.04-1.53) n.a. Connolly SJ, et al.The long term multi-center observational study of dabigatran treatment in patients with atrial fibrillation (RELY-ABLE) study. Circulation. 2013;128:XX-XXX. Jan Basile, MD Atrial Fibrillation & Stroke Prevention
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