atrial fibrillation and stroke prevention - Continuing Medical ...
atrial fibrillation and stroke prevention - Continuing Medical ...
atrial fibrillation and stroke prevention - Continuing Medical ...
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Essentials in Primary Care Conference<br />
Wednesday, July 31, 2013<br />
RE-LY<br />
Time to First Stroke/Systemic Embolism<br />
0.05-<br />
Warfarin<br />
Dabigatran 110 mg<br />
Dabigatran 150 mg<br />
H<br />
R<br />
RR = 0.91<br />
p < 0.001 (NI)<br />
P< 0.034<br />
(Sup)<br />
RR = 0.66<br />
(95% CI: 0.53-<br />
0.82)<br />
p < 0.001 (NI)<br />
P< 0.001<br />
(Sup)<br />
0.04-<br />
0.03-<br />
0.02-<br />
0.01-<br />
0.00-<br />
0 6 12 18 24 30<br />
Months<br />
Connolly SJ et al. NEJM 2009;361:1139-51<br />
RE-LY: Major Bleeding<br />
p=0.31<br />
%<br />
major<br />
bleed<br />
3.5-<br />
3.0-<br />
2.5-<br />
2.0-<br />
1.5-<br />
1.0-<br />
0.5-<br />
p=0.003<br />
3.36%<br />
2.71%<br />
3.11%<br />
warfarin<br />
dabigatran<br />
110 mg bid<br />
dabigatran<br />
150 mg bid<br />
Connolly SJ et al. NEJM 2009;361:1139-51<br />
Jan Basile, MD<br />
Atrial Fibrillation & Stroke Prevention
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