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Dutch Boltz - Molecular Devices

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Voltage Dependent FRET Mechanism<br />

of Voltage Sensor Probes<br />

+ + + - - -<br />

V m<br />

+ + +<br />

- - -<br />

-70mV<br />

+50mV<br />

+ + +<br />

Extracellular<br />

FRET<br />

V m<br />

---<br />

Extracellular<br />

Intracellular<br />

---<br />

Donor CC2-<br />

DMPE<br />

Acceptor<br />

DiSBAC 2<br />

Intracellular<br />

+ + +<br />

6/14/2004 Cardiovascular Diseases 5

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