Lessons from Micronutrient Studies in Patients with Glucose ...
Lessons from Micronutrient Studies in Patients with Glucose ...
Lessons from Micronutrient Studies in Patients with Glucose ...
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Activation of Insul<strong>in</strong> Receptor Activity by Chromium<br />
apo<br />
chromodul<strong>in</strong><br />
IR<br />
I<br />
Cr +3<br />
Cr +3 -Transferr<strong>in</strong><br />
IR<br />
I<br />
Insul<strong>in</strong>-sensitive sensitive cell<br />
Insul<strong>in</strong> receptor activated<br />
chromodul<strong>in</strong><br />
[<strong>in</strong>sul<strong>in</strong>]<br />
<strong>in</strong> blood<br />
apochromodul<strong>in</strong><br />
+3<br />
+ 4 Cr +3<br />
K f<br />
~ 10 18 m M -1<br />
chromodul<strong>in</strong><br />
Ur<strong>in</strong>e<br />
IR<br />
I<br />
K m<br />
~ 250 pM<br />
IR<br />
I<br />
Insul<strong>in</strong> receptor fully activated<br />
Chromodul<strong>in</strong> loaded <strong>with</strong> Cr<br />
Adapted <strong>from</strong> V<strong>in</strong>cent, J Nutr 130:715, 2000
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