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Lessons from Micronutrient Studies in Patients with Glucose ...

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Vanadium Supplementation <strong>in</strong> Diabetes<br />

<strong>Glucose</strong> use - <strong>in</strong> NIDDM, no change <strong>in</strong> IDDM<br />

Non oxidative disposal - <strong>in</strong> NIDDM<br />

Hepatic glucose production - no change <strong>in</strong> NIDDM or<br />

IDDM<br />

Insul<strong>in</strong> requirement - <strong>in</strong> IDDM<br />

No significant change <strong>in</strong> fast<strong>in</strong>g glucose or<br />

HbA1C<br />

Sodium metavanadate (NaVO 3 ; 125 mg or ~ 50 mg V) for 2 wk<br />

<strong>Glucose</strong> metabolism: 2-step2<br />

euglycemic, hyper<strong>in</strong>sul<strong>in</strong>ic clamp<br />

Goldf<strong>in</strong>e et al, J Cl<strong>in</strong> Endocr<strong>in</strong>ol Metab 80: 3311, 1995

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