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of surgicaltumor is left behind or in which there in 50% in tumor size were observe in these patients. He<br />
doubt as to the following local extension, also recommended the use of chemotherapy for grades<br />
11 and 111 mesenchymal and dedifferentiated chon-<br />
Arien et al. (1970), suggested that radiotherapy drosarcomas.<br />
at 4000 rads to 6000 fads must be given in 4 to 5<br />
weeks interval or its equivalent. Althought the tumor Alen et al. (1970), also suggested that these tumors<br />
have been considered to be radioresistant, recent are stimulated by growth hormone and as such may<br />
studies tend to dispute this impression. Harwood et benefit by suppression of the pituitary activity by<br />
al. (1980), observed a 50% complete remission rate hypophysectomy. There were also indications that<br />
in Grade 1 tumors with a disease free status in 25% progrestational agents were employed to suppress these<br />
of these patients for 15 years or more with adjuvant tumors.<br />
radiotherapy.<br />
As stated by Vener et al. (1984),<br />
the prognosis<br />
Chemotherapy has also been used as part of the of these tumors of the head and neck is related to<br />
treatment for chondrosarcomas. Finn et al. (1984), the location of the primary lesion, presence nor absence<br />
observed good response of patients who received pre- of pain, adequacy of initial surgical excision and finally<br />
operative treatment with agents like cis-platinum, on the histologic grade of the neoplasm. Several authors<br />
cyclophosphamide, vincristinem, doxorubicin and give a five-year survival of chondrosarcoma of the<br />
decarbizine. Partial response meaning a decrease of face and jaw at 40 to 60%. However, these lesions<br />
TABLE1: Differentiationof BenignandWell-differentiatedCartilaginous<br />
Tumor=($iedman, 1989).<br />
....... i ....<br />
FEATURE Chondrosarcoma Chrodoma OstSarc ChondroidChordoma tl ,.<br />
,.. = , ..<br />
Cell of origin Chondroblast Notochord Osteoblast Possiblynotochord<br />
and Chondroblast<br />
Location Facialbones Midline(but may Possiblyanywhere<br />
in the head and mandible extend) but primarily<br />
andneck Mandible temporalbone<br />
and midline<br />
Ageof patient 3rd-Sthdecade 3rd.4th 3rd decade 3rd-5thdecade<br />
decade<br />
Radiographic 'Calcification Calcification, Dependson<br />
findings bonydestruc- bonydestruction state of Calcification;<br />
tion usually hyperostolJc, mineralization bonydestruction<br />
avascular,may avascular,may usuallyavascular;<br />
enhancew/CT enhancew/minimal<br />
CT enhancement<br />
w/CT<br />
Generally excisionw/ or excision+ radical_'esection<br />
accepted w/o radiation radiation (+) or (-)<br />
treatment radiation; excisionand<br />
possible<br />
therapy<br />
chemo.Tx<br />
Primary<br />
site of local local local with local<br />
recurrence<br />
metastasis<br />
Distant<br />
usuallyw/<br />
metastasis rare rare in fst & rare<br />
2ridyrs.<br />
(lung& brain)<br />
13
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