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These patients are new patients seen in the Table I<br />
clinic for acute rhinitis, and after taking the clinical<br />
history, vital signs and complete proper ENT Gradingof NasalSymptomScores<br />
examinations, an informed consent is obtained. Proper<br />
advice and precautions are given. Laboratory 0 = NOsymptoms;normal feeling<br />
examination performed are: CBC, Urinalysis, BUN, 1 = Mild symptoms; slightly bothersome<br />
Serum creatinine, Total bilirium, SGOT, SGPT and 2 = Moderatesymptoms; bothersome<br />
Alkaline phosphatase. Patients are then given buttolerable<br />
medication good for 3 days in an envelope, and are 3 = severe and intolerable<br />
advised how to take them and when to return for<br />
follow-up examinations and treatment. Patients are<br />
given a symptom diary card and are advised on how<br />
to recordhissypmtomsaftertaking the medicine. The Table II<br />
card is returned on the 1st follow-up visit (3days<br />
later). When the patients returnfor the first follow- RatingScorefor Therapeutic Response to Treatup<br />
treatment, vital signs and the clinical history ment<br />
concerning the improvement of their symptom and<br />
any adverseeffects aretaken andverified. Another 1 = excellent;all symptoms are relieved<br />
ENT check-up is done, and another envelope of 2 = Good; most symptoms are very much<br />
medicines good for 4 days is given to eachpatient,<br />
improvedbut Still mildly present<br />
The patientsare instructed to returnafter 4 days for 3 = Fair; some improvementbut more symp-<br />
2nd foUow-up visit. After 4 days, the patients toms are still present<br />
returnedandsame procedureis performed, andfinally 4 = Poor; minimal improvementor no<br />
the patient is given an envelopeof medicinesgood improvementat all<br />
for 7 days with a symptom diary card. The patient<br />
is advisedto return afterone weekfor final (3rd followup<br />
visit) clinical evaluation. After this is dsone, repeat Statistical analysis is done by unimpaired t-test<br />
laboratory examination: CBC, urinalysis, BUN, for continuous variables and chi-square for nominal<br />
serum creatinine, total bilimbin, SGOT, SGPT and variables to compare baseline and post-treatment<br />
alkaline phosphatase are performed, parameters between the 2 treatment groups. Friedman<br />
2-way Anova for ordinal data to detect within group<br />
Selection of patients: (1) patients of either sex changein each treatment and Mann-Whimey for ordinal<br />
should be above 12 years of age; (2) patients should data to detect between treatment change.<br />
be available to record their daily symptoms on the<br />
symptom diary card; (3) female patients must not Results<br />
be pregnant or lactating; (4) patients must have an<br />
unequivocal history of acute rhinitis; (5) patients Atotal of 60 patients were studied. Nine males<br />
with alllergic overlay must not be receiving any and 21 females were included in the Actifed group,<br />
immunotherapy; (6) patients should not have any while 8 males and 22 females were studied in the<br />
other serious illnesses or hypertension; (7) patients Claritin-D group. No statistical difference between<br />
should not have any abnormal laboratory test results; the two groups was observed. (See Table III)<br />
(8) patients must not be allergic to any antihistaminic<br />
preparation; and (9) patients should not be taking any Table III<br />
other antihistamine, decongestant or any other<br />
investigational drugs at least for onemonth before this SexDistribution of Patients<br />
investigation.<br />
Actifed Clarltin-D<br />
The recording is done as follows: (See Table I &<br />
Table II) Male 9 8<br />
Female 21 22 p = 0.77<br />
Total 30 30<br />
• 78
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