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Actifed's side effect of drowsiness is so severe REFERENCES:
that 93.3 % of these 30 cases experienced drowsiness
of varying degrees. In 10 cases or 33.3% in the
Actifed group, severe drowsiness was encountered so 1. Robert B. Berkowtz, MD; John T.Connel, MD;
much that 5 cases or 16.6% were dropped after their Albert J, Dietz MD; Saul M. Greentein, MD
first follow-up visit because they could not afibrd to and David G. Tinkelman, MD: The Effeccontinue
their work and were afraid to lose their jobs. tiveness of the Non-Sedating Antihistamine
Two cases dropped off from the study after the 2nd Loratadine plus Pseudoephedrine in the
follow-up visit for similar reasons. On the contrary, Syptomatic Management of the Common
among the 30 cases of Claritin-D group, no one Cold. Annals of Allergy 1989; 63:336-
dropped out because of severe drowsiness. Twenty 339.
percent of this group experienced slight drowsiness
on the first follow-up visit but it disappeared after 2. Felicidad Cua-Lim, MD, FPCP; Margaret C. Lim,
3 days. At the end of the study, nobody complained MD; Jose S. Ilao, MD,FPCP and Regina
of drowsiness. Mangay,MD: An Evaluation STudy on the
Efficay and Safety of Loratadine vs.
Other side effects were not significant in both Mebhyrolin in the Allergic Rhinitis. Phil.
groups except that one patient among the Actifed J. Internal Medicine 1990; 28:103-108.
group developed hypertension. Among the Claritin-
D group, 6 females developed loss of appetite although 3. Felicidad Cua-Lim, MD, FPCP; Margaret C.
their laboratory studies did not show any abnormality; Lira, MD; Jose S. Ilao, MD,FPCP and
these 6 females were extra pleased because the drug Regina Mangay,MD: Efficay and Safety of
helps them lose weight. Oral Loratadine 10 mg daily in Perennial
Allergic Rhinitis. Phil. J. Internal Medicine
All these observations were revealed at the end 1990; 28:109-115.
of the study when the symptom scoring cards were
received. ThisshowsthatClaritin-Disfarmoresuperior 4. Richard F. Lockey, MD and Roger W. Fox, MD
to Actifed in the treatment of acute rhinitis, et al: Loratadine (SCH 29851) 10 mg o.d.
vs. Clemastine 1 mg b.i.d, in the treatment
Claritin-D is not just very effective in relieving of Perennial Allergic Rhinitis. Immunolthe
severe symptom of acute rhinitis, but it is also well ogy and Allergy Practice 1989; 423-429.
tolerated by all patients, and it is very safe as demonstrated
by this study. 5. J. Grossman, MD; E.A Nronsky MD; B.O.
Lanier, MD; M.I. Linzmayer, MD; B.A.
Mess, MD; E.J. Schenkel, MD and J.C.
CONCLUSION Slemer, MD: Loratadine -psedoephedrine
Combination versus Placebo in Patients with
This study reveals that Claritin-D is far more Seasonal Allergic Rhinits. Annals of
superior to Actifed in terms of: Allergy 1989; 63:317-321.
1. improving the signs and symptoms 7. F.Estelle R. Simos, MD, FRCP (C): Loratadine
a Non-sedating Hi-receptor Antagonist.
2, improving the overall evaluation of acute Annals of Allergy 1989; 63:266-268.
rhinitis by the patients and the investigators.
3. well tolerated by the patients and absence of
side effects.
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