Inflammatory Bowel Disease - IAGH

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New markers for detection of CRC • Sialosyl-Tn is a mucin-associated carbohydrate antigen that may presage the development of dysplasia and CRC by several years • Allelic deletions and point mutations of tumor suppressor genes, as p53,Rb,mcc and APC have been found in dysplastic and cancerous UC • changes in nuclear DNA content are detectable earlier than histologic signs of premalignancy • the predictive value of aneuploidy is uncertain
•Until further data are available, evaluation for dysplasia remains the standard for cancer surveillance programs in IBD
Page 2 and 3: Farhad zamani Associated professor
Page 5 and 6: Pathogenesis • Different than for
Page 7 and 8: Crohn's disease and CRC • The ris
Page 9: Who is at Risk • UC and CD • Ex
Page 13 and 14: Chromoendoscopy • Topical applica
Page 20: Narrow Band Imaging • NBI employs
Page 27 and 28: Prevention of CRC • Primary preve
Page 29 and 30: Folic acid • Folate deficiency in
Page 31: Conclusions • 5-ASA & folic acid

Inflammatory Bowel Disease - IAGH

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