Inflammatory Bowel Disease - IAGH

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5-Aminosalicylic Acid • Decrease arachidonic acid metabolism • Inactivates reactive oxygen species • Increase apoptosis (NF-kB suppression) • Decrease IL-2 production( IL-2 stimulates clonal proliferation of T-cell ) • Activate peroxisome prolifeartor – activators receptor Y (PPAR)-anti-inflammatory and antiprolirative
Folic acid • Folate deficiency in UC: intestinal losses , poor intake, sulfasalazine (↓absorbtion) • Folate is essential for regeneration of methionine – purin and pyremidine synthesis • Folate ↓ is associated with DNA hypomethylation, abberant DNA synthesis and repair and decreased apoptesis • Folates sensitive fragile site on genes important for carcinogesis , like p53 suppressor gene
Page 2 and 3: Farhad zamani Associated professor
Page 5 and 6: Pathogenesis • Different than for
Page 7 and 8: Crohn's disease and CRC • The ris
Page 9 and 10: Who is at Risk • UC and CD • Ex
Page 11 and 12: •Until further data are available
Page 13 and 14: Chromoendoscopy • Topical applica
Page 20: Narrow Band Imaging • NBI employs
Page 27: Prevention of CRC • Primary preve
Page 31: Conclusions • 5-ASA & folic acid

Inflammatory Bowel Disease - IAGH

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