Inflammatory Bowel Disease - IAGH

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UDCA • Secondary bile acids are carcinogen and ↑ in cholestasis • If the excess cancer is in RT sided where secondary bile acids are highest then either UDCA or OLT can effective • Cohort study of 132 PSC pts with UC v. 196 UC pts • CRC/dysplasia - 33 (250/0) cases v. 11 (60/0) controls (P
Conclusions • 5-ASA & folic acid should be given for possible chemoprevention, & UDCA in PSC • Surveillance colonoscopy every 2-3 years • Random biopsies of normal appearing mucosa are still of benefit for dysplasia surveillance • Chromoendoscopy increases the sensitivity of detecting dysplasia in UC by less than 2-fold • NBI & AF are promising, but have not been sufficiently studied
Page 2 and 3: Farhad zamani Associated professor
Page 5 and 6: Pathogenesis • Different than for
Page 7 and 8: Crohn's disease and CRC • The ris
Page 9 and 10: Who is at Risk • UC and CD • Ex
Page 11 and 12: •Until further data are available
Page 13 and 14: Chromoendoscopy • Topical applica
Page 20: Narrow Band Imaging • NBI employs
Page 27 and 28: Prevention of CRC • Primary preve
Page 29: Folic acid • Folate deficiency in

Inflammatory Bowel Disease - IAGH

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