chapter 10, early development and axis formation in amphibians part-2
chapter 10, early development and axis formation in amphibians part-2
chapter 10, early development and axis formation in amphibians part-2
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Left-Right Axis: Pitx2 determ<strong>in</strong>es the<br />
direction of heart loop<strong>in</strong>g <strong>and</strong> gut coil<strong>in</strong>g<br />
Wild-type<br />
Injected Pitx2 <br />
Pitx2 <strong>in</strong> just left<br />
side of mesoderm.<br />
Counter-clockwise<br />
gut coil<strong>in</strong>g<br />
Pitx2 <strong>in</strong> both side<br />
of mesoderm<br />
R<strong>and</strong>om gut<br />
coil<strong>in</strong>g<br />
Nodal prote<strong>in</strong> establishes left-light polarity by activat<strong>in</strong>g Pitx2 on<br />
the left side of embryo.
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