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Cellular Defenses Against Radiation
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GOALS: • Provide an overall descr
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NCI REB Radiation Epidemiology Cour
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NCI REB Radiation Epidemiology Cour
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Cancer cells “evolve” into a hi
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WHY CHECKPOINTS Fidelity of cell di
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NCI REB Radiation Epidemiology Cour
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NCI REB Radiation Epidemiology Cour
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Cyclin/CDK complexes seem to be reg
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• At least two checkpoints are re
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DO DEFECTIVE CHECKPOINTS CAUSE CANC
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Radiation-Induced G2 delay in lymph
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NCI REB Radiation Epidemiology Cour
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Rothkamm and Lobrick, PNAS, 2003 NC
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Somatic Mutation and Cancer Environ
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Major DNA repair pathways: • Non-
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NCI REB Radiation Epidemiology Cour
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NCI REB Radiation Epidemiology Cour
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“… the failure of DNA repair in
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T. Lindahl and R.D. Wood, Science 2
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NER PATHWAY GENES GENE ALIASES DESC
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Mismatch repair associated tumors i
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Non-Homologous End Joining (NHEJ) N
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Illegitimate Recombination NCI REB
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TARGET THEORY NCI REB Radiation Epi
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A-T CELL CANCER CELL DEATH NCI REB
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OTHER TARGET QUESTIONS: • If DNA
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Mutations in Chk2 produce the Li-Fr
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CASE STUDY: Finding Molecular Targe
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NCI REB Radiation Epidemiology Cour
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- Page 63 and 64: Environmental Causes of BCC • UV
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- Page 69 and 70: Skin cancers have unique p53 mutati
- Page 71 and 72: For BCC, PTCH may be even a bigger
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- Page 75 and 76: Verónica Martín, Graciela Carrill
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- Page 79 and 80: PTCH may play a role in cell cycle
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- Page 83 and 84: Aszterbaum et al. Nature Med. 5:128
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- Page 95 and 96: CONFOUNDERS: AGE SKIN COLOR DOSE NC
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- Page 107 and 108: SKIN COLOR GEOGRAPHY Photograph by
- Page 109 and 110: DOSE NCI REB Radiation Epidemiology
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