Cellular Defenses Against Radiation-Induced Carcinogenesis:

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Age and DNA Repair Capacity (DRC) in BCC NCI REB <strong>Radiation</strong> Epidemiology Course, May 14, 2007 Wei et al. PNAS 90:1614, 1993 TJJ
Age-Dependent Reactive Oxygen Species (ROS) ROS generation w 4.5 4.2 4 3.5 3 2.7 2.5 2 1.5 2.0 2.3 1 0.5 0 8 24 48 80 Age (wee Exp Dematology 12:655, 2003 NCI REB <strong>Radiation</strong> Epidemiology Course, May 14, 2007 TJJ
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Cellular Defenses Against Radiation
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GOALS: • Provide an overall descr
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NCI REB Radiation Epidemiology Cour
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Cancer cells “evolve” into a hi
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WHY CHECKPOINTS Fidelity of cell di
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Cyclin/CDK complexes seem to be reg
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• At least two checkpoints are re
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DO DEFECTIVE CHECKPOINTS CAUSE CANC
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Radiation-Induced G2 delay in lymph
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Rothkamm and Lobrick, PNAS, 2003 NC
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Somatic Mutation and Cancer Environ
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Major DNA repair pathways: • Non-
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“… the failure of DNA repair in
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T. Lindahl and R.D. Wood, Science 2
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NER PATHWAY GENES GENE ALIASES DESC
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Mismatch repair associated tumors i
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Non-Homologous End Joining (NHEJ) N
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Page 49 and 50: TARGET THEORY NCI REB Radiation Epi
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Page 53 and 54: OTHER TARGET QUESTIONS: • If DNA
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