Cellular Defenses Against Radiation-Induced Carcinogenesis:
Cellular Defenses Against Radiation-Induced Carcinogenesis:
Cellular Defenses Against Radiation-Induced Carcinogenesis:
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Are radiation sensitivity genes and radiation carcinogenesis<br />
genes the same<br />
• Several radiation sensitivity genes are known (e.g. ATM), but generally<br />
these genes confer sensitivity specifically to radiation-induced killing.<br />
• <strong>Cellular</strong> radiosensitivity genes are potential radiation carcinogenesis genes,<br />
but association with increased cancer risk has not been established.<br />
• The problem may be that sensitivity to radiation lethality and radiation<br />
carcinogenesis may be competing phenotypes.<br />
DEATH<br />
CANCER<br />
NCI REB <strong>Radiation</strong> Epidemiology Course, May 14, 2007<br />
TJJ