- Page 1 and 2: Cellular Defenses Against Radiation
- Page 3: GOALS: • Provide an overall descr
- Page 7 and 8: NCI REB Radiation Epidemiology Cour
- Page 9 and 10: Cancer cells “evolve” into a hi
- Page 11 and 12: WHY CHECKPOINTS Fidelity of cell di
- Page 13 and 14: NCI REB Radiation Epidemiology Cour
- Page 15 and 16: NCI REB Radiation Epidemiology Cour
- Page 17 and 18: Cyclin/CDK complexes seem to be reg
- Page 19 and 20: • At least two checkpoints are re
- Page 21 and 22: DO DEFECTIVE CHECKPOINTS CAUSE CANC
- Page 23 and 24: Radiation-Induced G2 delay in lymph
- Page 25 and 26: NCI REB Radiation Epidemiology Cour
- Page 27 and 28: Rothkamm and Lobrick, PNAS, 2003 NC
- Page 29 and 30: Somatic Mutation and Cancer Environ
- Page 31 and 32: Major DNA repair pathways: • Non-
- Page 33 and 34: NCI REB Radiation Epidemiology Cour
- Page 35 and 36: NCI REB Radiation Epidemiology Cour
- Page 37 and 38: “… the failure of DNA repair in
- Page 39 and 40: T. Lindahl and R.D. Wood, Science 2
- Page 41 and 42: NER PATHWAY GENES GENE ALIASES DESC
- Page 43 and 44: Mismatch repair associated tumors i
- Page 45 and 46: Non-Homologous End Joining (NHEJ) N
- Page 47 and 48: Illegitimate Recombination NCI REB
- Page 49 and 50: TARGET THEORY NCI REB Radiation Epi
- Page 51 and 52: A-T CELL CANCER CELL DEATH NCI REB
- Page 53 and 54: OTHER TARGET QUESTIONS: • If DNA
- Page 55 and 56:
Mutations in Chk2 produce the Li-Fr
- Page 57 and 58:
CASE STUDY: Finding Molecular Targe
- Page 59 and 60:
NCI REB Radiation Epidemiology Cour
- Page 61 and 62:
NCI REB Radiation Epidemiology Cour
- Page 63 and 64:
Environmental Causes of BCC • UV
- Page 65 and 66:
UV DAMAGE TO DNA NCI REB Radiation
- Page 67 and 68:
NER PATHWAY GENES GENE ALIASES DESC
- Page 69 and 70:
Skin cancers have unique p53 mutati
- Page 71 and 72:
For BCC, PTCH may be even a bigger
- Page 73 and 74:
Gorlin Syndrome • Nevoid basal ce
- Page 75 and 76:
Verónica Martín, Graciela Carrill
- Page 77 and 78:
Taipale J and Beachy PA Nature 411:
- Page 79 and 80:
PTCH may play a role in cell cycle
- Page 81 and 82:
NCI REB Radiation Epidemiology Cour
- Page 83 and 84:
Aszterbaum et al. Nature Med. 5:128
- Page 85 and 86:
Shh, PTCH, and SUFU mutations produ
- Page 87 and 88:
Thomas et al., J. Postgrad Med. 49:
- Page 89 and 90:
NCI REB Radiation Epidemiology Cour
- Page 91 and 92:
Veratrum californicum (corn lily) N
- Page 93 and 94:
Frank-Kamenetsky et al. J. Biol. 1:
- Page 95 and 96:
CONFOUNDERS: AGE SKIN COLOR DOSE NC
- Page 97 and 98:
• A disease of accelerated aging.
- Page 99 and 100:
Age-Dependent Reactive Oxygen Speci
- Page 101 and 102:
SKIN COLOR GENETICS NCI REB Radiati
- Page 103 and 104:
Am J Epidemiol 155: 614, 2002 Melan
- Page 105 and 106:
Melanocortin 1 Receptor gene (MC1R)
- Page 107 and 108:
SKIN COLOR GEOGRAPHY Photograph by
- Page 109 and 110:
DOSE NCI REB Radiation Epidemiology
- Page 111 and 112:
National Geographic Magazine April
- Page 113 and 114:
Aging genes (I.e. non-DNA repair) A
- Page 115 and 116:
RR for XP patients by age 8000 8000
- Page 117 and 118:
Radiation as a Model Carcinogen: